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Biomedical subjects

D Aderka

Publications and source records attributed to D Aderka.

At least 109 records · Page 6Linked to original sources
PubMed1982

Systemic lupus erythematosus - a state of hyperinterferonemia?

On the basis of immunologic and microbiologic data as well as recent observations it is postulated that interferon is responsible for many of the clinical signs and symptoms in systemic lupus erythematosus such as alopecia, joint manifestations, fever and leukopenia. Recognition of the important role of interferon in active systemic lupus erythematosus leads to some practical conclusions: a) a new therapeutic approach to active lupus must consider a treatment which will lead to reduced interferon activity; b) one of the laboratory parameters of activity of the disease may be interferon measurements.

Antibody Formation↗
PubMed1982

Morphological platelet anomalies in thrombotic thrombocytopenic purpura.

A patient with thrombotic thrombocytopenic purpura was treated with 8 U of fresh frozen plasma, resulting in a rapid improvement in her condition and subsequently followed by a prolonged clinical remission. The transmission and scanning electron microscopic examinations of the platelets performed before treatment demonstrated marked anomalies of the platelet morphology, namely, an increased number of abnormally elongated pseudopods with terminal knobs, a decreased number of platelet granules and excess of glycogen and marked anisocytosis. These anomalies remained unchanged when reexamined 2 months after the achievement of the clinical remission. The question whether these platelet abnormalities are an integral part of thrombotic thrombocytopenic purpura and play a role in its pathogenesis, is raised.

Blood Coagulation Factors↗
PubMed1980

Life-threatening hypophosphatemia in a patient with acute myelogenous leukemia.

A patient with acute myelogenous leukemia developed severe hypophosphatemia manifesting by extreme weakness, confusion, loss of sphincter control, nuchal rigidity, hyperesthesia, hemolysis, congestive heart failure and liver dysfunction. The possible causes for this condition were starvation, parenteral glucose and saline administration, sepsis, hypokalemia and treatment with acetazolamide. A dramatic improvement was noted following phosphate administration.

Acetazolamide↗
PubMed1980

Viral hepatitis with extreme hyperbilirubinemia, massive hemolysis and encephalopathy in a patient with a new G6PD variant.

Extreme hyperbilirubinemia, massive hemolysis and hepatic encephalopathy were reported in a G6PD-deficient patient with viral hepatitis. Investigation of the G6PD properties revealed that this patient's enzyme represented a hitherto undescribed variant (Bnei Brak), characterized by heat stability and a unique triphasic pH-related enzyme activity curve. It is possible that the marked hemolytic process in this patient was enhanced by a further decrease in the activity of the already deficient enzyme during acidosis.

Adolescent↗
PubMed1979

Migration inhibition factor activity in sera of patients with chronic lymphatic leukemia.

Migration inhibition factor (MIF) activity, expressed as a migration index, was studied in the sera of 48 chronic lymphatic leukemia (CLL) patients and 48 healthy controls. MIF activity was detected in the sera of 50% of the CLL patients. The medical condition of patients in advanced clinical stages (III and IV) and with detectable MIF activity was more stable (after 18-mo follow-up) than was that of the patients in advanced stages but without detectable MIF activity. No relationship was found between the clinical stage of the disease, absolute lymphocyte count, and MIF activity.

Adult↗
PubMed1979

Occupational acroosteolysis in vinyl chloride workers in Israel.

Exposure to vinyl chloride monomer (VCM) may result in a bizarre syndrome, which is characterized by lytic changes in the distal phalanges, cutaneous stigmata of scleroderma, and Raynaud's phenomenon. Detailed case histories of two such patients are presented. Epidemiologic, pathogenetic and radiological aspects of occupational acroosteolysis are briefly reviewed. The possibility is emphasized that the condition may result not only from industrial (i.e., occupational) exposure to VCM but also from exposure in the home or neighborhood (i.e., nonoccupational).

Adult↗
PubMed1979

Acute myocardial infarction in a hemophiliac.

An acute myocardial infarction was observed in a 62-year-old patient with hemophilia A, as well as myxedema, hypertension, obesity, hypercholesterolemia and angina pectoris. The occurrence of myocardial infarction in hemophiliacs is rare, and, to the best of our knowledge, this patient represents the fourth documented case in the literature.

Hemophilia A↗