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D Abendroth

Publications and source records attributed to D Abendroth.

At least 91 records · Page 5Linked to original sources
PubMed1989

Metabolic control and effect on secondary complications of diabetes mellitus by pancreatic transplantation.

After successful pancreatic transplantation blood glucose can be normalized without exogenous insulin, although oral and intravenous glucose tolerance remains impaired in 10-45% of the patients. There is no significant deterioration of glucose control with time in most patients. Since most recipients of pancreatic grafts have far advanced secondary diabetic lesions and the observation time after grafting is rather short, the effects of pancreatic transplantation on these complications are difficult to interpret. However, the development of diabetic nephropathy can be prevented, skin microcirculation improves significantly, while autonomic and peripheral neuropathy and diabetic retinopathy remain stable or improve slightly in most patients. But these ameliorations may be in part due to elimination of uraemia, since in almost all patients combined pancreas/kidney transplantations were performed. It is concluded that pancreas grafting probably has to be performed much earlier in the course of diabetes, although the improvement in the quality of life is striking even in the end-stage diabetics studied so far.

Blood Glucose↗
PubMed1989

Angiography of segmental pancreatic transplants.

Arteriography was routinely performed in patients with suspected vascular complications after pancreas transplantation. Dysfunction of the grafts was suggested by 99mTc-DTPA scanning and metabolic tests. Thirty arteriograms obtained in 25 patients were evaluated. Nineteen conventional film angiograms and 11 intraarterial DSA were performed. Five different angiographic patterns were observed: normal vascular anatomy, low-flow phenomenon, arterial or venous thrombosis, and venous neovascularity. On the basis of the angiographic findings, various reasons for graft failure were identified. Recipient venous collaterals or well-functioning grafts without angiographically detectable blood supply were observed in 9 cases, and must be considered to represent neovascularisation by donor and recipient vessels.

Angiography, Digital Subtraction↗
PubMed1988

Renal transplantation at the Munich Transplant Center: a retrospective single-center review.

The use of different immunosuppressive protocols (high-dose/low-dose CsA) has little effect on first cadaveric transplants in nonsensitized patients. However, low-dose CsA induction treatment reduces early nephrotoxic crises. There is a clear benefit of quadruple drug induction treatment for retransplants and sensitized transplant candidates. Steroid-free immunosuppressive therapy can be applied to a majority of long-term patients.

Cyclosporins↗
PubMed1988

Pancreatic transplantation using the duct occlusion technique.

Since 1979, the Munich Group has gathered experience with 100 consecutive pancreas transplants using the duct occlusion technique. At the present time, 40 of the pancreas grafts (44%) and 56 of the renal grafts (65%) of 90 patients who received both a pancreas and a kidney are still functioning. The mortality rate of 18% in the early period was relatively high. In the period from 1984 until 1988--using the simple transplantation technique--only one patient died. During this period, our overall results improved with the use of a modified surgical technique and different immunosuppressive and anticoagulative measures along with better patient selection. Normalization of the glucose metabolism seems to improve the rate of late diabetic complications. The duct occlusion technique in isolated pancreas transplants might have been a disadvantage in accounting for the poor results. With regard to metabolic studies, there is now ample evidence to suggest that successful pancreatic transplantation leads to complete normalization of glucose metabolism including normoglycemia in more than 70% of all patients. In addition, clinical data are accumulating that suggest successful pancreatic transplantation has a beneficial effect on the late secondary syndrome of Type I diabetes mellitus.

Cyclosporins↗