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Biomedical subjects

D A Tyrrell

Publications and source records attributed to D A Tyrrell.

At least 217 records · Page 12Linked to original sources
PubMed1974

Replication or inactivation of different viruses by human lymphocyte preparations.

Cultures of phytohemagglutinin-stimulated, unstimulated, and frozen and thawed mononuclear (as controls) cells from normal human donors were infected with different viruses. A variable pattern of virus infectivity was noted, and influenza and Coxsackie virus were rapidly inactivated even by stimulated lymphocytes. Direct inactivation by lymphocytes may be one form of host defense in infection by some viruses.

Adenoviridae↗
PubMed1974

Picornaviridae.

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Enterovirus↗
PubMed1973

Skin tests with influenza virus.

Skin reactions have been produced in normal subjects by the injection of highly purified influenza A and B viruses. The reactions reached a maximum at 24-48 hr. and the histological pattern was compatible with a delayed hypersensitivity reaction. There was no close relation between skin test results and circulating antibodies. Twenty-seven subjects were challenged intranasally with attenuated influenza A (H3N2): 5 of 14 skin-test-negative subjects were infected, but none of 13 skin-test-positive subjects.

Adolescent↗
PubMed1973

An epidemic of influenza on Tristan da Cunha.

Respiratory disease on Tristan da Cunha has been observed since the islanders returned in 1962. An epidemic of unprecedented severity occurred in the winter of 1971 and involved 273 (96%) of 284 islanders, 92 of whom had two attacks.The epidemic was apparently introduced by the Tristania.The illness of both first and second attacks ranged from mild to severe but there were some differences. There were two deaths, both in elderly persons with chronic chest disease and heart failure. Serological evidence suggests that this was due to influenza A2 of the Hong Kong serotype H(3)N(2).

Aged↗