Prolonged survival of rats receiving kidney allografts perfused with concanavalin A.
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Animals↗
Biomedical subjects
D A Coleman
Publications and source records attributed to D A Coleman.
Predicted mortality patterns in cohort study populations exposed to different types of hazard: can SMRs show a dose-response?
The analysis of data from cohort studies by duration of exposure and time since first exposure (latent interval) has been investigated using a simulation approach. These two analyses are often performed when the estimator of risk, commonly the O/E ratio or SMR, shows evidence of a raised risk. Two measures of risk were tested in the detailed analyses: the O/E ratio and the excess death rate. The latter was found to reflect the 'dose-response' relationship more accurately for a variety of hazard types. Attention is drawn to possible biases and to the importance of adjustment for age in these analyses.
Adolescent↗
MR angiography for preoperative evaluation of vascularized fibular grafts.
PURPOSE: Two magnetic resonance (MR) angiography pulse sequences, two-dimensional (2D) time of flight (TOF) and multislab three-dimensional (3D) TOF, were compared for ease of application and capability of depicting the arterial trifurcation in candidates for vascularized fibular grafts. PATIENTS AND METHODS: Both 2D TOF and multislab 3D TOF MR angiography procedures were performed to image the lower legs of 15 healthy volunteers and six patients. Three radiologists evaluated each study for the number of trifurcation vessels depicted at the knee and at the ankle, the corresponding degree of confidence, and the presence of anatomic variants. RESULTS: All trifurcation vessels were identified at the level of the knee with a high degree of confidence. Usually two vessels could be identified at the ankle with a slightly lower degree of confidence. A higher number of vessels were identified at the ankle with the 2D TOF technique than with the 3D TOF technique. A number of anatomic variants were identified. Anatomy of all six patients was identified correctly and confirmed at surgery. CONCLUSION: Both 2D TOF and multislab 3D TOF are useful techniques to define the arterial anatomy of the lower leg and have proved valuable in preoperative planning for vascularized grafts. Vessel visualization at the level of the ankle was superior with the 2D TOF technique.
Fibula↗
Vascularized fibular grafts for salvage reconstruction of clavicle nonunion.
Three cases of persistent nonunion of the clavicle with segmental bone loss were treated with autogenous, vascularized fibular grafts. In each case, the patient presented with pain and shoulder dysfunction after an average of 3.7 procedures. Each case was characterized by segmental bone loss that failed to unite after treatment of clavicle nonunion by traditional means. Union was achieved in all 3 cases. Average follow-up was 2.8 years. Both pain and shoulder function were improved with the procedure. To date, the use of vascularized fibular grafts has not been described in clavicle reconstruction. We believe that vascularized fibular grafting may be used successfully as a salvage procedure when traditional means of achieving union have failed.
Adult↗
Some genetical inferences from the marriage system of Reading, Berkshire, and its surround area.
A survey of marriages celebrated in 1972/73 in Reading, Berkshire, and its urban field was carried out in 1974. It provided information about the birthplace of husband and wife and of their parents, about their joint home after marriage, and on their social class origins. These data were used to produce a migration-matrix showing the probability of movement from one part of the area (and the outside world) to all the other parts of the area. A modification of the iterative deterministic model of Hiorns et al. (1969) permitted estimates to be made of the number of generations which would elapse before all the subdivisions of the survey area shared 95% of the same ancestry, assuming an initial state of zero relatedness between them and the continuation of current patterns of marital mobility. Without contributions from the 'outside world', the 18 subdivisions of the survey area become ancestrally homogeneous with each other within 3--15 generations, while with contributions from the 'outside world', the process takes not more than six generations. Marriages between social classes combined with intergeneration social mobility make the ancestry of these classes homogeneous after four generations at most.
England↗
The effect of socio-economic class, regional origin and other variables on marital mobility in Britain 1920-1960.
A survey carried out by the Population Investigation Committee in 1959-1960 provides nationwide data on the marital mobility of marriage cohorts from 1920 to 1960. These mobility data are analysed by socio-economic class, religious affiliation and regional origin. After adjustment for the influences of covariates, the most important factors affecting mobility were the socio-economic class of wife's father, husband and husband's father in that order. Significant variation in mobility also exists with respect to regional origin, but differences in mobility between the adherents of different religions were much less striking. An attempt is made to account for the working of these factors using other material from the P.I.C. survey and from other sources.
Female↗
Congenital pseudarthrosis of the tibia: treatment by transfer of the ipsilateral fibula with vascular pedicle.
We performed five transfers of the ipsilateral fibula in the treatment of congenital pseudarthrosis of the tibia. In all cases, conventional treatment by intramedullary-rod and autogenous-iliac bone grafting had failed at least once. We hoped to avoid the use of contralateral-fibular grafting or other methods that have not yet been proven effective. The ipsilateral fibula was transferred, and its vascular pedicle left intact and secured to both fragments of the tibial pseudarthrosis by cerclage wires. All five transfers have united and hypertrophied with growth. We believe this salvage method is superior to others not only because of the successful results, but also because the intact limb is left undisturbed.
Child↗
Universal precautions--an imperative for the health care provider.
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Acquired Immunodeficiency Syndrome↗
From Task Force on Issues Related to AIDS. I don't need those anymore!
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Acquired Immunodeficiency Syndrome↗
Microvascularized free fibular grafts for reconstruction of skeletal defects after tumor resection.
A microvascularized free fibular graft was used to reconstruct a skeletal defect after tumor reconstruction in 13 consecutive patients. The patients were evaluated at an average follow-up of 53 months (range, 30-71). The status of each graft was evaluated for time to union, hypertrophy, functional evaluation, and complications. The average time to union was 6.5 months, and significant graft hypertrophy occurred in eight of 13 patients. Complications occurred in seven patients. Two of the 13 patients required removal of the microvascularized graft. Functional evaluation according the the Musculoskeletal Tumor Society yielded an average score of 90 (range, 83-97). The results were rated good or excellent in 11 of 13 patients, and two were rated failures. The microvascularized fibular graft provides an attractive option for the reconstruction of skeletal defects after tumor resection. The results of this procedure are especially good in skeletally immature patients.
Adolescent↗