Biomedical subjects
Publications and source records attributed to D A Coleman.
Pigmented villonodular synovitis involving the wrist joint and adjacent carpal bones occurred in a 42-year-old female. This is an extremely rare lesion. A case report of this unusual entity is presented, with a review of the medical literature.
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We conducted two studies to determine how herd management practices and traits of individual cows affect performance of the herd and of the cow within a herd. Management practices, reproductive performance of the herd, and relationships between management and reproductive performance were characterized on 83 dairy farms with 7596 cows. Data included 21 management variables (e.g., facilities, herd health program, estrous detection program) and 8 performance variables obtained from Dairy Herd Improvement or unofficial records (e.g., size of herd, production, days open). Although varying among herds, annual average herd incidences of reproductive disorders and reproductive performance were similar to those reported. Managerial practices influenced incidences of retained placenta and uterine infection, days open of cows not bred and of all cows, services per conception, and percentages of herd open more than 100 days and culled for low production. Veterinarian was the most consistent variable influencing herd reproductive performance. Data also were collected from production and lifetime records of 2532 cows in 19 herds. Reproductive performance was affected by season of calving, production, maturity, and reproductive disorders. Several cows with extremely poor reproductive records were maintained.
Osteocutaneous flaps from the foot are being utilized more for thumb and digit reconstruction. We have presented a few unique situations in which these flaps are beneficial. Not all patients with deformities similar to those described in this presentation should have these reconstructive procedures. The patient must understand the risks of donor site morbidity and possible complications. However, the advantages of this technique are that only one surgical procedure is necessary, the hospitalization is short, the cosmetic result is good, and the functional restoration is satisfactory.
Two experiments were conducted to identify the temporal limits of an ovarian compensatory response after unilateral ovariectomy (ULO) in gilts and to examine ovarian and hormonal factors that might be related to this response. In the first study, all eight gilts that were unilaterally ovariectomized on d 12, 14 or 16 of an estrous cycle and two of four ULO on d 18 had a significant compensatory increase in ovulation rate per ovary compared with controls. Ovulatory compensation failed to occur, however, in two of four and four of four gilts ULO on d 18 or 19 of an estrous cycle, respectively. In the second study, blood samples were collected from 26 gilts beginning on d 14 of an estrous cycle, and animals were assigned to sham-surgery or ULO on d 17, 18 or 19. Ovarian compensation occurred after ULO on all 3 d of surgery in the second study, but most follicles failed to ovulate and formed large luteinized cysts. The ability to compensate was related positively to the number of medium-sized follicles on the intact ovary at the time of ULO, to an increase in concentrations of follicle-stimulating hormone 12 to 18 h after ULO and to the interval from ULO to the preovulatory surge of luteinizing hormone. In a third experiment, interruption of the ovulatory mechanism and development of cystic follicles similar to those observed in the second study were induced simply by physical manipulation of the d 19 preovulatory ovary while contralateral untouched ovaries ovulated normally.
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Preovulatory follicles were removed from ewes during estrus to determine hormonal, ovarian and behavioral responses. In Experiment 1, new follicles were recruited and ovulated within 4 days, and a second estrous period was observed in most ewes. In Experiment 2, follicles were removed at Day 0 (estrus), Day 3.5 and Day 7.0 to determine responses to repeated follicular removal in the absence of a corpus luteum (CL). Ewes in two groups were given exogenous progestin at the time of first or second surgery. Each follicular removal was followed by a surge of follicle-stimulating hormone (FSH) and follicular growth, and in many cases, behavioral estrus and/or a surge of luteinizing hormone (LH) was detected around the time of the next follicular removal. Although not necessary for display of estrus, treatment with progestin during follicular maturation increased the number of ewes showing estrus. When the newly developing follicles were allowed to ovulate, resulting corpora lutea produced low levels of progesterone or had a short life span.
A random sample was taken of marriages celebrated in 1972/1973 in and around Reading, Berksshire, in order to investigate marital mobility and population structure. Respondents were asked whether they were related before marriage and isonymous marriages were noted. Eight consanguineous marriages were recorded. The inbreeding coefficient for the next generation is estimated to be 0.00017 from consanguineous marriages, 0.00021 from isonymy. These values are similar to those obtained from other modern Western societies.
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In 1959 the Population Investigation Committee at the London School of Economics instituted a nationwide survey of attitudes of marriage, contraception and family size. Questions were also asked about the birthplace of the partners and where they were living when they first met each other. These four place names provide the basis for marital mobility data whose geographical distribution is described here. A simple model of marital mobility is presented and the data are analysed according to (1) the propensity to marry outside the individual's birthplace or home town and (2) the distribution of the distan(e separating the partners when they come from different places. The data are very heterogeneous, so they are broken down for further analysis according to the population sizes of the birthplaces and home towns of each partner. The propensity to marry within the same place is strongly and positively associated with its population size. If the partners come from different places when the distance between their birthplaces, or between their home towns when they met, is associated with the population size of these places. Similar associations were found between the probability of migration from the birthplace, the distance moved, and population size. Men are more likely to move from their birthplaces than are women, and if they move they are more likely to move further. Marriage distance, as defined here, is also strongly influenced by population size. The geographical theory of central places offers a suitable framework for understanding the relation of marital mobility and population size and the results of this study are discussed in the context of geographical theories.
A nationwide sample survey of 2338 married couples provides information on the birthplaces and residences at meeting of couples first married between 1920 and 1960. Four measures of marital mobility are analysed according to year of marriage and year of first meeting. In their original form all measures show the expected increase in mobility from the 1920s to the 1930s with an exceptionally steep rise in the 1940s and a decline after the Second World War. The role of the war in promoting migration both of civilians and of soldiers is briefly reviewed. Women show rather different migration patterns from those of men. Age at marriage is positively correlated with movement in this sample, but a stronger association is provided by age at first meeting. Mobility averages for each cohort are adjusted for the changes in age at marriage, both real and peculiar to this sample, which have occurred since 1920, and also for variation in the population sizes of birthplaces in the sample over time, and changes in the relative frequencies of different socio-economic classes. After adjustment, little ghange is seen in material mobility over the four decades covered by the survey and many of the differences which do remain after adjustment lack statistical significance. Some socio-economic explanations are offered for these conclusions.
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Long-term survival of Ag-B compatible rat heart allografts was obtained by short-term treatment of the recipients with antilymphocytic serum (ALS). Graft survival apparently was based on a specific change in the hosts rather than on persistent nonspecific effects of ALS. The hosts were not fully tolerant in that they were able to reject secondary skin allografts from the heart donor strain, although in a delayed fashion. The long-surviving heart allografts retained their immunogenicity as they were rejected when retransplanted to new hosts. The passive transfer of serum from long-term heart graft acceptors to new hosts receiving fresh allografts delayed rejection by several days. This effect was seen only with the serum from long-term acceptors suggesting that serum-blocking factors were involved in long-term survival of the heart allografts. However, the ability of adoptively transferred lymphoid cells to break tolerance to a heart allograft residing in a classically tolerant host was tested. In contrast to normal lymphoid cells, cells from the long-term acceptors were unable to break tolerance, suggesting that a specific cellular tolerance had been induced in this cell population. Moreover, a serum from the long-term acceptors failed to block the breakage of tolerance by normal lymphoid cells.