Biomedical subjects

Cosma Andreula

Publications and source records attributed to Cosma Andreula.

4 recordsLinked to original sources

PubMed2005

Metastatic disease of the spine.

Metastases of the spine occur in the spinal cord, dura extramedullary, epidural space, and vertebral bodies. Imaging modalities can be used to evaluate patient symptoms, screen and detect lesions, assess localization and the compartments involved (extradural, epidural, subdural, and paraspinal), and suggest therapeutic strategies. The suggested flow chart for metastases is (1) in asymptomatic patients suspected for metastases and (2) in the patient with neurological symptoms. Imaging modalities are indispensable in differential diagnosis because some nontumoral lesions can mimic metastases.

Humans↗

PubMed2005

Congenital bilateral perisylvian syndrome with partial epilepsy. Case report with long-term follow-up.

Congenital bilateral perisylvian syndrome (CBPS) is a rare neurological disorder characterised by pseudobulbar palsy, cognitive deficits and epilepsy associated with bilateral perisylvian cortical dysplasia on neuroimaging studies. We report a long-term follow-up of a 18-years girl diagnosed with CBPS according to the typical clinical and magnetic resonance imaging (MRI) features. The patient showed faciopharyngoglossomasticatory diplegia, severe dysarthria, ataxia, spastic quadriparesis and severe mental retardation. Brain MRI evidenced bilateral perisylvian cortical dysplasia. Since early life she suffered from complex febrile seizures and epilepsy consisting of complex partial attacks with affective manifestations associated with centro-temporal EEG abnormalities. During 18 years of follow-up she was treated with phenobarbital, carbamazepine, lamotrigine, gabapentin but did not show any significant clinical improvement. Subsequently, monotherapy with phenytoin (PHT) was followed by a significant clinical improvement. At age 17, because of adverse effects, PHT was gradually substituted by topiramate (TPM). Full control of seizures was obtained at the age of 17 years with TPM. EEG abnormalities throughout the years have been reduced according to the clinical course. These findings emphasised the importance of long-term follow-up, suggesting that the prognosis for epilepsy may not be predicted based on the early response to treatment or on the presence of structural encephalic abnormalities, as reported in the literature.

Adolescent↗

PubMed2004

Cranial viral infections in the adult.

Viral infections of the adult are fortunately rare conditions but may carry serious clinical sequelae. Infection is usually acquired by haematogenous spread during a systemic viral illness and may be acute, subacute or chronic. The pathological basis of neuronal degeneration and attempt to repair is common to all illnesses and diagnosis is generally made by analysis of the pattern of disease. Magnetic resonance imaging is now the mainstay of imaging diagnosis. Acute infections include encephalitis due to a wide range of infecting agents and outcome depends on the severity of the acute episode. Subacute and chronic infections, including HIV encephalopathy, most often produce a progressive leucoencephalopathy and ultimately cerebral atrophy. Additionally, disease may also be immune mediated, that most closely associated with viral infection being acute disseminated encephalomyelitis, which is usually a monophasic illness. Finally, prion diseases are characterised by long incubation period and progressive course, leading to death.

AIDS Dementia Complex↗

PubMed2004

Interventional spinal procedures.

The interventional procedures for disk herniation and protrusion by percutaneous techniques are decompressive such as chemodiscolysis with chimopapain, nucleo-discectomy introduced by Onik, LASER discectomy, and recently nucleoplasty, and decompressive and direct antinflammatory such as chemiodiscolysis with an Oxygen-ozone mixture. These techniques have minimized the invasive nature of surgery and avoid or decrease complications like infection linked to surgery. Reducing intervertebral disc size by mechanical aspiration of a part of the disc or partially dissolving the herniation by drying reduces the conic pressure on the torn annulus and creates the space necessary for retropulsion whenever the circular fibres of the annulus regain a minimum capacity to contain the disc under tension. The proposed suggestion in these techniques is that a small change in volume produces large change in pressure. The success rates reported in different studies vary from 65 to 80% of excellent or good results with chemonucleolysis and aspiration. Vertebroplasty (VP) is done by percutaneous injection of acrylic cement (polymethylmetacrylate-PMMA) into the vertebrae under fluoroscopic and/or CT control to achieve an antalgic effect and stabilize the vertebral body. VP has been used for vertebral collapses caused by osteoporosis, long-term steroid treatment, aggressive symptomatic angiomas and lytic metastasis. The reported figures in literature are 80-95% of pain relief, within 7 days after procedure, commonly on the same day.

Bone Cements↗