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Biomedical subjects

C Zielinski

Publications and source records attributed to C Zielinski.

72 records · Page 4Linked to original sources
PubMed1985

[Aminoglutethimide therapy in advanced breast cancer].

45 women (postmenopausal or after former oophorectomy) with metastatic breast cancer resistant to tamoxifen as well as to chemo- and radiotherapy were treated with aminoglutethimide (750 mg or 1000 mg resp. daily) and hydrocortisone (40 mg daily). Treatment resulted in 33% remissions (2 CR + 13 PR) and 53% stabilizations (24 patients) besides a non-responder rate of 13% (6 patients). Side effects (mainly central sedation, possibly exanthema, seldom anorexia, but no hematotoxicity) were observed in 13 patients (29%). Duration of remission lasted for 1 to 24 months (mean duration 10,5 months) while stabilization extended for 2 to 17 months (mean duration 7,7 months). Mechanism of action by enzymatic inhibition of the adrenal steroid hormone synthesis ("medical adrenalectomy") as well as by extra-adrenal diminution of estrogens is considered in detail. Aminoglutethimide provides effective treatment in patients with generalized metastatic breast cancer followed by best outcome in cases with osseous metastases. Clinical results are presented as an approach to successful therapy of advanced breast cancer and an endocrine alternative in tamoxifen resistance as well as a therapeutic possibility in cytotoxic induced pancytopenia.

Adult↗
PubMed1982

Influence of hip arthroplasty upon chemotactic behaviour of leucocytes.

Fourteen patients treated with total hip endoprosthesis were investigated for leucocyte defects. A chemotactic assay was used as an indicator of leucocyte function. Tests were carried out preoperatively and on postoperative days 1, 3 and 6. The chemotactic index started to decline on the first postoperative day, reached a peak on the third day after surgery and returned to almost preoperative values on the sixth day. The results might provide a clinical explanation for the data showing a high postoperative infection rate in total hip surgery.

Aged↗
PubMed1980

Con A-induced suppressor cells in children with acute lymphoblastic leukaemia.

The function of Con A stimulation was investigated in patients with ALL in remission and in patients with ALL in the acute phase of the disease as compared to healthy controls. Suppression of the Con A response brought about by autologous Con A-activated cells was significantly lower in ALL patients in remission (mean value 29.33%) and in the acute phase (mean value 10%) than in the controls (mean value 64.86%). Suppression of the Con A stimulation of control lymphocytes by Con A-activated homologous cells of ALL patients had a mean value of 51.65%. This was significantly higher than the suppression obtained by the same ALL cells in the autologous system and of the same order of magnitude as the suppression obtained by control Con A-activated cells on control Con A stimulation (57.67%). Suppression of the Con a response of ALL lymphocytes produced by control Con A-activated cells was 23.17% and comparable to healthy controls. These results demonstrate that the function of Con A-induced suppression is significantly lower in ALL patients. They further indicate that at least two cell types are involved in this kind of suppression in humans.

Acute Disease↗
PubMed1979

Collagen types and anticollagen-antibodies in Dupuytren's disease.

The relative proportion of collagen type I and type III in the aponeurosis of twenty-four patients with Dupuytren's disease was determined and compared with the aponeurosis of normal persons. The presence of considerable amounts of type III collagen was found in the Dupuytren's disease patients. The sera of the patients were screened for circulating anti-collagen antibodies using a sensitive radioimmunoassay. In seven out of the twenty-four patients low concentrations of these antibodies were found.

Adult↗
PubMed1978

[Detection of collagenase in passive haemagglutination using collagen-coated erythrocytes (author's transl)].

Human rheumatoid arthritis (RA) collagenase and bacterial collagenase were shown to agglutinate collagen-coated erythrocytes. Native collagens of type I and type II reacted equally well, while denatured collagens showed less distinct agglutination activity. The sensitivity of the method for the detection of purified bacterial collagenase from Clostridium histolyticum is very high (100 pg). It is, however, low for human RA collagenase. The agglutination reaction is not inhibited by concentrations of native collagen causing distinct inhibition of anticollagen sera (2mg%). EDTA inhibits the agglutination completely.

Arthritis, Rheumatoid↗
PubMed1978

[The influence of surgery upon leucocyte function (author's transl)].

14 patients who underwent a standardized total hip joint replacement were investigated in order to detect postoperative impairment of chemotactic or phagocytic function of their polymorphonuclear leucocytes. A chemotaxis assay in modified Boyden [3] chambers and the nitroblue-tetrazolium assay were used. 25 healthy control persons served for the assessment of normal values and the reproducibility of the respective test. Patients were investigated preoperatively and on the first, third and sixth postoperative day. While phagocytosis remained unchanged throughout the period of investigation, chemotactic leucocyte function was regularly significantly depressed on the first postoperative day. The defect in postoperative chemotaxis might, despite of an unimpaired phagocytic capacity, contribute towards an increased risk of postoperative infections.

Aged↗
PubMed1978

[The influence of metabolic control on chemotactic activity in insulin-dependent diabetes mellitus (author's transl)].

An increased incidence of infections, especially during periods of poor metabolic control is well known in patients with insulin-dependent diabetes mellitus. Therefore, we studied polymorphonuclear chemotaxis and its dependence on the degree of diabetic control in 49 patients with insulin-dependent diabetes mellitus in 46 controls. A modification of the chemotaxis assay described by Frei et al. was used as test system. The mean chemotactic activity observed in the total group of insulin-dependent diabetics did not differ from the values obtained in the controls. However, in patients with poor diabetic control and glucosuria exceeding 60 g/24h, a significantly reduced chemotactic leucoyte migration was found. These data indicate that normalization of leucotaxis can be achieved in insulin-dependent diabetes by means of adequate diabetes control.

Adult↗
PubMedDate not supplied

Arterial hepatic embolization of unresectable hepatocellular carcinoma using a cyanoacrylate/lipiodol mixture.

PURPOSE: A survival analysis in 16 patients with unresectable hepatocellular carcinoma (HCC) undergoing transcatheter arterial embolization (TAE) using a combination of lipiodol and N-butyl-2-cyanoacrylate (5:1) was performed in a retrospective study. METHODS: A combination of lipiodol and N-butyl-2-cyanoacrylate (5:1) was used for TAE. All patients had disease compatible with Okuda stages I and II. RESULTS: Twenty-four embolizations were done; five patients had more than one embolization. Median alpha-fetoprotein levels declined from 116 to 48.6 ng/ml. A median of 0.3 ml cyanoacrylate was administered per patient. Median survival was 8.5 months (range 2-49 months). After a median follow-up of 4 years, 12 patients have died (75%). Okuda stage I and II patients had a median survival time of 34.4 and 5.5 months respectively. Few side effects (19%) were seen. CONCLUSION: We conclude that the TAE procedure used [lipiodol and N-butyl-2-cyanoacrylate (5:1)] is safe and produced only few side effects, thus constituting a valuable therapeutic option for patients with Okuda stage I and II HCC.

Aged↗
PubMedDate not supplied

Shortcomings of low-cost imaging systems for viewing computed radiographs.

OBJECTIVE: To assess potential advantages of a new PC-based viewing tool featuring image post-processing for viewing computed radiographs on low-cost hardware (PC) with a common display card and color monitor, and to evaluate the effect of using color versus monochrome monitors. MATERIALS AND METHODS: Computed radiographs of a statistical phantom were viewed on a PC, with and without post-processing (spatial frequency and contrast processing), employing a monochrome or a color monitor. Findings were compared with the viewing on a radiological Workstation and evaluated with ROC analysis. RESULTS: Image post-processing improved the perception of low-contrast details significantly irrespective of the monitor used. No significant difference in perception was observed between monochrome and color monitors. The review at the radiological Workstation was superior to the review done using the PC with image processing. CONCLUSION: Lower quality hardware (graphic card and monitor) used in low cost PCs negatively affects perception of low-contrast details in computed radiographs. In this situation, it is highly recommended to use spatial frequency and contrast processing. No significant quality gain has been observed for the high-end monochrome monitor compared to the color display. However, the color monitor was affected stronger by high ambient illumination.

Humans↗
PubMedDate not supplied

Collagenase-induced experimental arthritis.

Rabbits were injected intraarticularly three times with 0.5 ml of 10, 50 or 100 mg% purified rheumatoid synovial collagenase or with identical amounts of trypsin. 18 hours after the last injection the collagenase-injected animals showed distinct cellular exudation into the synovial fluid and acute arthritis; one week later there was a decrease of the cell count in the synovial fluid and appearance of proliferative synovitis, while 3 weeks later there was no exudation and less chronic inflammation but distinct fibrosis of the synovium. A direct action of collagenase on the connective tissue components would seem to be responsible for these changes. No pathologic alteration of the cartilage was observed. Trypsin-injected control animals showed negligible cellular exudation and no pathologic alteration of the synovium.

Animals↗
PubMedDate not supplied

Leucocyte migration inhibition with collagen type I and collagen type III in rheumatoid arthritis and degenerative joint diseases.

The leucocytes of 22 patients with classic rheumatoid arthritis were investigated with the direct leucocyte migration inhibition technique in agarose as described by Clausen. The leucocytes of 9 patients with degenerative joint diseases and of 9 healthy persons served as controls. Collagen type I and collagen type III were used as antigens. The leucocytes of 22 patients with rheumatoid arthritis showed in 15 cases a migration inhibition with collagen type III and in 10 cases with collagen type I. The inhibition with collagen type III was stronger and more frequent than with collagen type I. The frequent leucocyte migration inhibition with collagen type III in classic rheumatoid arthritis seems to be an expression of possible cell mediated reactivity against that type of collagen which appears especially in rheumatoid synovial tissue.

Adult↗
PubMedDate not supplied

Leukocyte locomotion and regulative serum effects in rheumatoid arthritis.

Leukocyte locomotion (LL) of 40 patients with rheumatoid arthritis (RA) was found to be unimpaired as compared to LL of 23 control individuals (p Greater Than 0.2). Casein and zymosan activated human sera were used as cytotaxins, and the sera of RA patients proved to be activatable in the same way as control sera in that they produced a similar chemotactic activity (p Greater Than 0.2). However, RA sera inhibited LL significantly (p Less Than 0.01) in comparison to control sera. This phenomenon was unchanged after elimination of immune complexes be ultracentrifugation, but could be reversed, after incubation of cells with RA sera, by reincubation with control sera.

Adult↗
PubMedDate not supplied

Acute autoimmune collagen-induced arthritis in rabbits.

Three groups of rabbits were investigated: I. 9 rabbits, immunized with rabbit collagen type I, received 1 intraarticular injection of same antigen in the right knee, and control preparations in the left knee. II. 4 rabbits, immunized with calf collagen type I, received the same intraarticular injections as in group I. III. 2 non-immunized rabbits received also the same intraarticular injections. Synovial fluid and synovium were obtained in all groups 18 hours after intraarticular injection. Knee-joints of all animals immunized and challenged intraarticularly with rabbit collagen showed strong cellular exsudation (mean 1.800 X 10(3) cells,) in contrast to control joints (mean 21 to 484 X 10(3) cells). Histologic investigation of synovium of group I animals showed in rabbit collagen injected knees in contrast to controls, vascular reactions with enlargement of small vessels, thikening of endothelial cells, perivascular infiltration and aggregation of polymorphonuclears in lumen of vessels. Intraarticular injection of rabbit collagen in calf collagen immunized rabbits, induced a limited cellular exsudation, (mean 670 X 10(3) cells) which was lower than in rabbit collagen immunized animals, however also more pronounced than in control joints. Whilst results after intraarticular injection of rabbit collagen in rabbit collagen immunized animals are interpreted as early signs of autoimmune arthritis, results after intraarticular injection of rabbit collagen in calf collagen immunized animals are regarded as milder symptoms of synovitis induced by crossreactivity of antigens.

Animals↗