Biomedical subjects

C Y Kuo

Publications and source records attributed to C Y Kuo.

75 records · Page 5Linked to original sources

PubMedDate not supplied

Histologic appearance of the islet organoid.

The authors have attempted to develop a hybrid organoid capable of supporting the engraftment of human pancreatic islet tissue transplants. In this report, they we report the histologic appearance of this organoid structure for implantation periods up to 16 days. Both pancreatic duct-like and glandular cells were present inside the organoid. Insulin positive cells were identified within the pancreatic tissue. Although polymorphonuclear (PMN) cells were seen in association with tissue necrosis, the authors observed no lymphocyte infiltration in the area of the xenografted human pancreatic islet tissue in the implanted organoid. Endothelial cell growth factor induced neovascularization inside the organoid sufficient to support the engraftment of transplanted pancreatic islet tissue. This organoid model may provide an alternative for clinical pancreatic transplantation.

Animals↗

PubMedDate not supplied

The effect of decoction of Artemisia, Rheum, and Gardeniae in a piglet model of hyperbilirubinemia.

To find an alternative treatment for neonatal hyperbilirubinemia, the effect of a decoction of Artemisia Rheum Gardeniae was tested in an animal model. Fifteen male newborn piglets (four to six days old) were separated into three groups (five piglets/group). The animals of the first group, or Control Group, were intravenously infused with purified bilirubin (40 mg/kg) to simulate neonatal indirect hyperbilirubinemia. The animals of the second and the third groups received the decoction via oral-gastric tube feeding (Enteral Treatment Group) and intravenous injection (Parenteral Treatment Group), respectively, after infusion of bilirubin. Serum bilirubin levels were determined at 0, 0.5, 1, 2, 4 and 8 hours in these groups. The results revealed no significant effect of the decoction on hyperbilirubinemia within eight hours. The implication of this study suggests that a decoction of Artemisia Rheum Gardeniae may be not useful in the treatment of neonatal hyperbilirubinemia.

Animals↗

PubMedDate not supplied

Relief of protracted hypercarbia by high-frequency oscillatory ventilator in a young infant with bronchopulmonary dysplasia.

Conventional ventilators have their limitations in management of certain conditions such as protracted hypercarbia in bronchopulmonary dysplasia (BPD). Although high-frequency ventilators (HFV) may be less effective in patients with lung diseases complicated by high airway resistance, such as BPD, high-frequency oscillatory ventilators (HFOV) can still provide an alternative treatment of choice due to its property of active exhalation, in addition to its tidal volume being less than dead space and its minute ventilation being more dependent on tidal volume. This report describes 3 episodes of successful relief of protracted hypercarbia in a young infant with BPD using HFOV after failure of conventional ventilatory therapy.

Bronchopulmonary Dysplasia↗