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Biomedical subjects

C Watts

Publications and source records attributed to C Watts.

At least 217 records · Page 12Linked to original sources

Recognizing spontaneous spinal epidural hematoma.

Sudden, often severe pain in the spinal region that is followed-sometimes within minutes-by paraplegia may signal spontaneous spinal epidural hematoma. This is a true surgical emergency calling for immediate laminectomy. Otherwise, the neurologic deficit becomes irreversible and the patient probably will die. The cause may be a fall or straining but in most cases there's no history of trauma. A myelogram reveals a block at the level of the hematoma, usually in the thoracic region or in the cervicothoracic or thoracolumbar area. Manometric tests shouldn't be done because they can increase the neurologic deficit. Urinary retention and sensitivity to pinprick at the level of the hematoma are additional diagnostic clues. The case reported here and 13 others from the literature point up the importance of prompt surgical treatment. Eight of the 12 patients who had laminectomy improved and five of them recovered completly, but both of the patients who were not treated surgically died.

Aged↗

The management of intracranial calcified subdural hematomas.

Calcified subdural hematomas are associated with signs and symptoms similar to those of chronic, uncalcified subdural hematomas. Those found incidentally or in patients with long-standing nonprogressive neurological deficits should be left alone. If a calcified subdural hematoma is discovered in the evaluation of a patient with an acute or a progressing neurological disorder, an operation should be considered.

Adolescent↗

Chymopapain treatment of intervertebral disc disease.

In the first of a two-part study, the authors review the known biochemical, pharmacological, toxicological, and experimental data concerning chymopapain and the intervertebral disc. They describe the action of this proteolytic enzyme, which apparently disrupts the protein mucopolysaccharide component of disc material, most marked in the nucleus pulposus. A rapid conversion to collagen causes a loss of disc space height; toxicity appears to result from alteration of bonding between capillary endothelial cells that in turn produces hemorrhage. Part 2 reviews significant reported results and complications of clinical chemonucleolysis.

Anaphylaxis↗

Comparison of intervertebral disc disease treatment by chymopapain injection and open surgery.

Chymopapain chemonucleolysis was performed on 100 patients with primary lumbar intervertebral disc disease. The results were compared with those of 174 patients who underwent laminotomy, foraminotomy, and discectomy. Primary lumbar intervertebral disc disease was arbitrarily divided into degenerative, complex, previous surgical, and simple disc syndromes. No difference was seen between chemonucleolysis and surgery in the first three divisions; between 55 percent and 60 per cent of patients responded successfully to treatment. In the simple disc division 89 per cent of the surgical and 60 per cent of the chemonucleolysis patients had successful results.

Adult↗