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Biomedical subjects

C Vogel

Publications and source records attributed to C Vogel.

At least 127 records · Page 7Linked to original sources
PubMed1977

A comparison of cyclophosphamide, adriamycin, 5-fluorouracil (CAF) and cyclophosphamide, methotrexate, 5-fluorouracil, vincristine, prednisone (CMFVP) in patients with metastatic breast cancer: a Southeastern Cancer Study Group project.

In an ongoing prospective randomized study, 113 evaluable patients have received either a three-drug combination that included cyclophosphamide, Adriamycin and 5-fluorouracil (CAF) or a five-drug combination including cyclophosphamide, methotrexate, 5-fluorouracil, vincristine and prednisone (CMFVP) given intermittently 1 week out of 4. Responses (64%), median duration of response (32 weeks), and median duration of disease control (32 weeks) achieved with CAF were superior to those achieved with CMFVP (37%, 22 weeks, 17 weeks, respectively). Morbidity secondary to CAF was significant, with nausea and vomiting, malaise, total alopecia, and granulocytopenia being the main features.

Agranulocytosis↗
PubMed1976

[Investigations concerning serum concentration and temperature following oral application of a new paracetamol preparation (author's transl)].

A new, highly concentrated, fluid paracetamol preparation (paracetamol fluid) was tested on 26 small children and school children. The children were divided into 3 groups on the basis of dosage (5, 10 and 20 mg/kg body weight). The paracetamol serum concentration was determined and the temperature reactions noted. The resorption was rapid; maximum serum level was usually reached after 30 minutes. In most cases, maximum drop in temperature, however, occurred in 3-4 hours. The most obvious and longest lasting drop in temperature was achieved fol following 20 mg/kg body weight dose of the paracetamol preparation. Doses of 5 mg/kg body weight had no significant affect on elevated body temperatures. The most favorable dosage then is between 10-20 mg/kg body weight. The paracetamol concentration in the children under study never exceeded that of 20 mug/ml, even with the higher doses (20 mg/kg). This is far below the toxic threshold of 120 mug/ml. Even higher paracetamol doses of 40 mg/kg body weight, such as may be acciddentally administered, only resulted in a maximum serum level of 50 mug/ml and, therefore, were far below the toxic threshold.

Acetaminophen↗