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Biomedical subjects

C Urban

Publications and source records attributed to C Urban.

At least 181 records · Page 10Linked to original sources
PubMed1981

[Mucocutaneous lymph node syndrome in Austria. Four cases with one fatal outcome. 2. Pathological findings].

First pathoanatomic case report of mucocutaneous lymph-node syndrome (MCLS) from Austria: A 3 1/2 year old boy was admitted to the Pediatric Department with a six day history of fever and bilateral conjunctivitis. He showed a maculous exanthema, red and fissuring lips, reddened tonsils and a coated tongue. Submandibular lymph nodes were swollen (1 cm diameter); ESR 128/138; peripheral leukocytosis 17 x 10(9)/l. On the tenth day of illness membranous desquamation from the fingertips and a strawberry tongue was observed. The ECG showed a myocardial infarction in the apical portion of the left ventricle. The boy died on the 25th day of illness. Pathological findings were found predominantly in the heart: Coronary arteries showed fibrous thickening of intimal layer, focal destruction of elastic membrane and aneurysms in both arteries. The aneurysm in the descending branch of the left coronary artery was 15 mm long and had a maximum diameter of 8 mm. It was completely occluded by a thrombus. Recurring anteroseptal myocardial infarction. Other investigated arteries were not affected. Tonsils as well as (paratracheal and parapancreatic) lymph-nodes showed a few ceroid pigment containing histiocytes.

Aneurysm↗
PubMed1981

[Intracranial germinoma; typical CT appearances and radiation therapy (author's transl)].

The typical CT appearances of intracranial germinomas are described in three cases. These consist of an isodense or hyperdense tumour in the mid-line, originating from the pineal body or infundibulum, with marked increase in density on contrast enhancement. Periventricular tumour expansion in relation to the entire supratentorial ventricular system is characteristic. The rapid tumour regression after small doses of radiation is stressed and complete regression of the tumour, as seen on CT, is a sign of its radio-curability.

Adolescent↗
PubMed1981

Partial purification and characterization of human gamma (immune) interferon.

Human gamma (immune) interferon (IFN-gamma) was produced in lymphocyte cultures stimulated with a phorbol ester (12-O-tetradecanoylphorbol 13-acetate) and purified phytohemagglutinin. Physicochemical analysis showed that human IFN-gamma is a glycoprotein with an isoelectric point around 8.6 and an apparent molecular weight of 58,000 +/- 3000. A purification process for IFN-gamma was developed consisting of sequential chromatographic separations on controlled-pore glass, concanavalin A-Sepharose, and Bio-Gel P-200. This purification process resulted in an increase in specific activity from about 10(4) (crude culture fluid) to an estimated 10(7) units per mg of protein with a cumulative recovery of about 40% of the IFN activity.

Chromatography, Affinity↗
PubMed1981

[Problems of Hodgkin's disease in childhood].

Many publications about treatment results of Hodgkin's disease in adults give a rather optimistic outlook. Our experience with the treatment results of 10 children between 1970 and 1980 is rather disappointing due to late side effects of the combined treatment modalities. These complications of therapy and guidelines form the management of various stages of Hodgkin's disease are discussed.

Child↗
PubMed1981

Autologous and allogeneic MLC-reactivity in patients with rheumatoid arthritis.

In vitro interaction of autologous peripheral blood and synovial fluid lymphocytes was studied using isolated lymphocytes from 15 patients with rheumatoid arthritis. In the applied one way mixed lymphocyte cultures (MLC) a significant proliferative response was obtained when peripheral blood lymphocytes were cultured with mitomycin treated synovial fluid cells. In contrast, when the reverse situation was examined, only a marginal stimulation of synovial fluid lymphocytes by peripheral blood lymphocytes was recorded. Studies on the effect of macrophage depletion on the autologous MLC made in unlikely that the decreased proliferative response of SFL was due to the presence of a monocyte suppressor cell population in SFL. Likewise no evidence could be obtained that the decreased MLC response of SFL to autologous and allogeneic lymphocytes was caused by the predominance of short lived T-suppressor cells in the synovial fluid.

Arthritis, Rheumatoid↗
PubMed1981

[Intrapericardial rhabdomyosarcoma in infancy (author's transl)].

At the age of three months an infant rapidly developed signs of cardiac failure as well as in- and exspiratory stridor, caused by an intrathoracic tumor. Thoracotomy and biopsy revealed an intrapericardial tumor, histologically myxosarcoma. In spite of chemotherapy and radiation the infant died at the age of seven months due to multiple intracerebral metastases now histologically rhabdomyosarcoma. This is one of the rare cases of primarily malignant intrapericardial tumors in infancy, and also shows the possible pleomorphism of childhood rhabdomyosarcoma. We know only one further case of pericardial rhabdomyosarcoma where similar histologic changes have been observed.

Biopsy↗
PubMed1980

[BCG-infection in chronic granulomatous disease (author's transl)].

A 7 year old boy developed in the newborn period a chronic suppurative process after routine BCG vaccination beginning at the site of the injection and spreading to the adjacent areas on neck and chin. A supraclavicular lymphadenopathy was also noted. Serial histological examinations revealed the typical histopathological pattern of tuberculosis and the boy received a tuberculostatic therapy for five years. During this time he suffered from multiple chronic bacterial infections which led to chronic granulomatous inflammations in different organs and to a fibrous pneumonitis with subsequent cor pulmonale. At the age of 6 years a negative NBT-test allowed the diagnosis of GCD. Consequently therapy with Sulfamethoxazol-Trimethoprim was started and the rate of infections diminished markedly.

BCG Vaccine↗
PubMed1980

[Bio-availability of phenytoin free-acid serum level determinations whilst using a lactose-based tablet-preparation (author's transl)].

Phenytoin serum levels were determined in 103 children during the steady state of phenytoin therapy using a radio-immuno-assay. 94% of the patients had been treated as outpatients, 54% received phenytoin in combination with other antiepileptic drugs. The preparation used was phenytoin as free acid in lactose tablets (Epilan D). A therapeutic serum level of 10-20 mcg/ml was reached by an oral intake of 6,1 +/- 1,6 mg/kg/d. 27 children had plasma levels above 20 mcg/ml, their oral dose was 7,1 +/- 1,8 mg/kg/d. Most of these children showed clinical signs of intoxication. The bioavailability of phenytoin preparations is not only depended on the type of the substance used (salt, free acid), but also on the excipients used for the preparation of tablets. Therefore, general dosage recommendations are useless and even dangerous, unless the preparations used are extensively specified.

Biological Availability↗
PubMed1979

[(Management of acute toxicity after high dose methotrexate therapy)].

A 13-year-old girl with osteosarcoma and pulmonary metastases developed life-threatening renal toxicity, encephalopathy, and bone marrow failure following high dose methotrexate therapy. After successful treatment, high dose methotrexate therapy was continued without further problems. Recommendations for the prevention and the current management of methotrexate toxicity are discussed.

Adolescent↗
PubMed1979

[Immunosuppressive treatment of endogenous uveitis in childhood (author's transl)].

This report is about a seven year old boy suffering from endogenous uveitis of unknown etiology in both eyes. A local and systemical steroid therapy did not stop the progressive course. Therefore an immunosuppressive treatment with methotrexate was begun. After the second intravenous application of this antifolate an amelioration could be noted and after 6 week a normalisation of the visual acuity on the left eye and an improvement from 0.4 to 0.8 on the right eye was obtained. Immunosuppressive treatment was discontinued after a duration of 14 months; now 2 years later, the inital success has been maintained. The advantages of methotrexate in comparison to other immunosuppressive agents are discussed.

Child↗
PubMed1979

[Thrombasthenia in a newborn (author's transl)].

Thrombasthenia is an extemely rare hereditary disorder of platelet function characterized by impairment of adhesiveness, ADP-induced aggregation, and clot retraction. Petechiae and ecchymoses in a newborn infant followed by prolonged jaundice facilitated early diagnosis.

Blood Coagulation Factors↗
PubMed1979

[Septic arthritis and osteomyelitis as a complication of neonatal intensive care (author's transl)].

In a prematurely born infant of a diabetic mother a purulent arthritis with osteomyelitis of the elbow occurred 18 days after an enterobacter aerogenes-septicemia was proved. Enterobacter (aerobacter) aerogenes is a nosocomial gramnegative germ, that is more and more regarded responsible for infection of the newborn in intensive care units. In accordance with the literature recording a high rate functional loss after septic arthritis also our patient suffered from a mobility deficiency in his right elbow a year after the onset of the disease.

Anti-Bacterial Agents↗
PubMed1979

[Mucocutaneous lymph node syndrome in Austria -- Report of four cases; one with cardiac arrest. First of two parts: clinical observations (author's transl)].

Since October 1978, four cases of mucocutaneous lymph node syndrome, a disease previously not yet described in our country were observed in our childrens hospital. This particular disease has been described quite frequently in Japan since 1967. It has a characteristic manifestation being mostly benign and self limited. In a few cases however acute cardiac arrest has been described. The first case we observed expired as a result of acute coronary infarction on the twentyfifth day of illness although clinical improvement had been previously noted. At post mortem examination the coronary arteries showed changes consistent with arteriitis. The following three cases presented the more typical benign course of this disease one of them with deformities of the coronary arteries. The clinical synopsis describes the above mentioned cases.

Adrenal Cortex Hormones↗
PubMed1978

[Make a diagnosis].

Explore the source record for details and available documents.

Diagnosis, Differential↗