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Biomedical subjects

C Toker

Publications and source records attributed to C Toker.

At least 37 records · Page 2Linked to original sources
PubMed1981

Müllerian adenosarcoma of the uterine cervix.

We present a tumor of the uterine cervix that was composed of histologically benign glandular epithelium and a malignant stromal component, justifying the term müllerian adenosarcoma. Ultrastructurally the stromal cells resemble the endometrial stromal cells, the tumor cells of an endolymphatic stromal myosis of the uterine cervix, and the stromal cells of a stromomyoma of the uterus. In addition there is evidence strongly suggesting a differentiation toward smooth muscle. The patient exhibited no evidence of disease one year after surgery.

Female↗
PubMed1981

An unusual pelvic tumor with benign glandular, sarcomatous, and Wilms' tumor-like components.

We present a pelvic tumor occurring in a 23 year old woman in which a Wilms' tumor-like element was predominant. The presence of a benign glandular component surrounded by small spindle and round malignant cells paralleled that encountered in adenosarcoma of the uterine body and cervix. The possible histogenesis is discussed. Clinically the recurrent tumor showed evidence of a response to chemotherapy. Treatment was complicated by petit mal seizures, for which adriamycin was responsible. The patient exhibited no evidence of disease 22 months after the first operation.

Adult↗
PubMed1980

Lymphomatoid papulosis. Ultrastructural study with demonstration of intranuclear and intracytoplasmic viruslike particles.

Transmission electron microscopic study of the bizarre infiltrating cells from a case of lymphomatoid papulosis reveals intranuclear and intracytoplasmic virus-like particles. These cells have large nuclei with multiple nucleoli, scant to moderate profiles of rough endoplasmic reticulum, mitochondria and a variable number of lysosomes. It is suggested that these abnormal cells are macrophages showing viral cytopathogenic effects.

Adult↗
PubMed1980

Primary leiomyosarcoma of bone.

A primary tumor of bone, the light microscopic features of which were suggestive of malignant fibrous histiocytoma, proved to be a primary leiomyosarcoma upon electron microscopic examination. Ultrastructurally the tumor cells were smooth muscle cells having all the characteristic features, such as cytoplasmic filaments, cytoplasmic and sarcolemmal dense bodies, and pinocytotic vesicles, with a basal lamina surrounding the cells. This example emphasizes the importance of electron microscopy in diagnostic pathology. This is the second ultrastructural report of a primary leiomyosarcoma of bone.

Aged↗
PubMed1979

Stromomyoma of the uterus.

We present a solitary uterine tumor that occurred in a 28-year-old woman who complained of vaginal bleeding. Grossly, the tumor was well circumscribed and composed of lobulated tissue that varied from yellow, tan and soft, to white and rubbery. At the light microscopic level, areas identical to those described and interpreted as sex-cord differentiation in a group of closely similar uterine tumors were found and obtained for electron microscopic study. Ultrastructurally, there were two basic types of cells, neither of which can be interpreted as sex-cord derivatives. Cells that closely resembled the predominant components of Clement and Scully's group I tumors were similar to the normal endometrial stromal cells. Cells that formed plexiform cords demonstrated features diagnostic of smooth muscle cells. Cellular contents in cells comprising the tubular structures resembling that interpreted as indistinguishable from that of a Sertoli-cell tumor (tubular androblastoma) were probably smooth muscle cells. We propose the term "Stromomyoma" to designate this peculiar uterine tumor. The similarity between our tumor and those reported in the literature raises the possibility that "uterine tumor resembling" ovarian sex-cord tumors" are actually stromomyomas.

Adult↗
PubMed1979

Primary low grade adenocarcinoma occurring in the inguinal region.

An unusual case of primary adenocarcinoma occurring in the inguinal region of an elderly woman is reported. It appeared to have arisen from the mesothelium of the canal of Nuck. It recurred and involved one inguinal lymph node three years after the diagnosis and seven years after the initial appearance of the mass. The absence of associated peritoneal tumor distinguishes this case from other reported primary malignant neoplasms of the hernial sac.

Adenocarcinoma, Papillary↗
PubMed1979

Myxoid adrenal cortical carcinoma: a light and electron microscopic study.

An adrenal cortical carcinoma demonstrating a peculiar myxoid background similar to that of a myxoma was found in a 41-year-old woman who also had parathyroid hyperplasia and clinical evidence of a pituitary tumor. The electron microscopic study demonstrated its value in establishing the diagnosis that was not possible to make with absolute certainty at the light microscopic level alone. The combination of endocrine disorders strongly suggests the possibility of an unusual multiple endocrine syndrome.

Adrenal Cortex Neoplasms↗
PubMed1978

Lymphoepithelioma of the vocal cord.

Lymphoepithelioma is a predominantly nasopharyngeal tumor with some incidence elsewhere in the pharynx. Occurrence in other sites is unusual. This report presents an example of a lymphoepithelioma arising in the vocal cord. The basal cells of the squamous epithelium lining the tonsillar crypts bear a close resemblance to the cells of this tumor, and they are intimately related to lymphoid tissue. It is our belief that lymphoepitheliomas arise from the basal zone and that the basal layer of epithelium even further afield might on occasion produce the lesion.

Aged↗
PubMed1978

Trabecular carcinoma of the skin: an ultrastructural study.

We report the electron microscopic studies of three trabecular carcinomas of the skin. The presence of neurosecretory granules in all three tumors suggests that trabecular carcinoma originates from one of the neurocrest derivatives, most probably, Merkel cells. The ultrastructural findings confirm Toker's original concept that trabecular carcinomas comprise a distinct group of skin tumor. The recognition of these tumors would enable one to make such a diagnosis on frozen section, which, in turn, might provide an opportunity for more specific cytochemical and immunofluorescent characterization.

Adenocarcinoma↗
PubMed1978

Glomangioma of the lung.

An unusual pulmonary tumor was identified on the basis of light and electron microscopic findings as glomangioma. The ultrastructural findings of intracytoplasmic fibrils with dense bodies, electron-dense plaques, pinocytotic vesicles, and basement membranes are consistent with smooth muscle origin. The differential diagnosis between our tumor and other unusual tumors is discussed. The occurrence of a glomangioma in the lung may indicate the existence of pulmonary glomera.

Aged↗
PubMed1978

Hilus cell tumor of the ovary and endometrial carcinoma.

A case of hilus cell tumour of the ovary was found in a patient with adenocarcinoma of the endometrium, the sixth such case reported in the literature. Serum levels of estradiol-17beta, progesterone, and testosterone were measured before and after surgical removal of the tumor and after dexamethasone suppression in the postoperative period. Only testosterone appeared to be related to the presence of the hilus cell tumor; its levels decreased after removal of the tumor.

Adenocarcinoma↗
PubMed1975

Primary adenocarcinoma of the middle ear.

Two patients with primary adenocarcinoma of the middle ear displayed symptoms in the affected ear many years before their condition was diagnosed as adenocarcinoma. Treatment included simple extirpation of the tumor, radical mastoidectomy with or without radiation. A review of the literature shows 11 cases reported previously. Follow-up of the patients for more than four years revealed four deaths in the reported cases-one from causes unrelated to the tumor and the others showing only local invasion without distant metastases. These tumors grow slowly and have a low-grade of malignancy.

Adenocarcinoma↗