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Biomedical subjects

C Toker

Publications and source records attributed to C Toker.

At least 19 recordsLinked to original sources
PubMed1987

Metastatic renal oncocytic neoplasm with benign histologic appearance.

We present a case of malignant renal oncocytoma which displayed a benign histologic appearance in the primary renal tumor and in metastases to the spine and liver. The case demonstrates the difficulty that may be encountered in distinguishing benign renal oncocytomas from malignant renal oncocytomas. Whereas, the accepted criteria will enable a distinction in the majority of instances, occasional instances may be encountered in which a benign histology does not provide an accurate reflection on the clinical course.

Adenoma↗
PubMed1986

Diffuse hyperplasia of lymph node in tuberculosis.

We have reported a case of diffuse hyperplasia of lymph nodes mimicking a malignant large cell lymphoma in a patient with active tuberculosis. The possibility of lymphoma coexisting with or superimposed upon the tuberculous infection proved untenable after a long follow-up. The potential of tuberculosis to produce florid lymphoid reactions should be taken into account when interpreting lymph node biopsies in similar clinical situations.

Adult↗
PubMed1986

Multicentric ovarian and extraovarian cystadenofibroma.

A case of multicentric ovarian and diffuse pelvic cystadenofibroma is described. Despite multicentricity, the histologic findings are completely benign. Electron microscopy was performed and possible mesothelial origin is discussed.

Adenofibroma↗
PubMed1985

Infiltrating recurrent renal angiomyolipoma with fatal outcome.

Renal angiomyolipomas are considered to be benign mesenchymal tumors despite histological findings often remarkable for cellular pleomorphism and mitoses. We report a renal angiomyolipoma in a 49-year-old white woman. Surgical treatment was followed by massive recurrence with perforation of the colon and invasion of the diaphragm. The patient died despite surgical debulking and radiation therapy. A review of the literature revealed 1 case of massive recurrence following partial resection of the tumor and 2 in which the tumor showed marked local invasion. We believe that patients with renal angiomyolipoma should be monitored carefully for aggressive tissue infiltration and recurrent tumor.

Female↗
PubMed1985

Carcinoma of the uterine cervix resembling lymphoepithelioma.

A case of cervical carcinoma with marked lymphocytic infiltration is described. The tumor is histologically similar to lymphoepithelioma of the nasopharyngeal region or medullary carcinoma of the breast. This tumor may have a favorable prognosis. Only two Japanese groups have reported this tumor as a distinctive entity. One such case is reported herein.

Carcinoma, Squamous Cell↗
PubMed1984

An atypical fibromyxoid tumor of the prostate.

An unusual fibromyxoid tumor of the prostate is described that may be confused with embryonal rhabdomyosarcoma (botryoid sarcoma). The cells were fibroblastic, and the tumor lacked mitotic activity. Rhabdomyoblasts were not seen under either light or electron microscopy. Although the cells presented a strap-like appearance, striations were not observed. Results of immunoperoxidase studies were also negative for muscle origin. The tumor has pursued a benign clinical course.

Fibroma↗
PubMed1983

Sweat gland tumor with glandular and spindle cell features.

We studied a sweat gland tumor by light and electron microscopy that displayed both well-differentiated glandular areas and an anaplastic spindle cell component suggestive of neuroendocrine differentiation. The Merkel cell or a primitive pleuropotential cell is considered to be the most likely cell of origin for this tumor.

Adenocarcinoma↗
PubMed1982

An ultrastructural study of angiomatoid fibrous histiocytoma.

We studied the electron microscopy of two tumors which clinically and histologically conformed to what has been described as angiomatoid fibrous histiocytoma, a tumor thought to be of fibrohistiocytic origin. The ultrastructure of one tumor was that of a cellular angioma and the second tumor a vascular lesion with fibroblasts and histiocyte-like mononuclear cells. Our findings suggest that angiomatoid fibrous histiocytomas are basically vascular tumors with fibroblasts and other cells as secondary participants in some lesions. The behaviour of angiomatoid fibrous histiocytoma cannot be predicted from histology. Our findings of different ultrastructural components in histologically non-separable tumors lead to a question whether different ultrastructural composition is correlated with different biological behavior of these tumors. Further studies of similar cases are required if tumor morphology is to be correlated with clinical behavior.

Child↗
PubMed1982

Basaloid tumor of the sigmoid colon.

A second case of basaloid carcinoma arising in the midsigmoid colon is reported. By light microscopy the tumor was seen to be composed of islands of small, poorly differentiated cells separated by cellular connective tissue. Also seen were small foci of keratinized cells, Ultrastructure study confirms the largely basal character of the tumor and also shows some cells containing tonofilament bundles, representing a more squamoid differentiation. The similarity of this tumor to basaloid tumors arising in the transitional epithelium of the anal canal is discussed, and the suggestion that the tumor arises from a pluripotential basal cell is made.

Aged↗
PubMed1982

Unusual cutaneous carcinoma with features of small cell (oat cell-like) and squamous cell carcinomas. A variant of malignant Merkel cell neoplasm.

Three unusual primary neoplasms in the skin that occurred in elderly patients (64, 77, and 69 years of age) are presented. Two histologic components were found in each of the three neoplasms, one being small cell or oat cell-like carcinoma and the other squamous cell carcinoma. Study by electron microscopy revealed neurosecretory granules, though few, in the small cell component. The lack of clinical evidence of oat cell carcinoma elsewhere, the autopsy finding of two histologic components in one patient, and the findings by conventional and electron microscopy lead us to conclude that these three neoplasms are primary in the skin and of Merkel cell origin. We suggest further that small cell carcinoma of the skin represents a poorly differentiated counterpart of trabecular carcinoma. The spectrum of malignant Merkel cell neoplasm is, therefore, expanding. Two of our three patients died of their neoplasms 2 and 2 1/2 years, respectively, after the initial diagnosis.

Adenocarcinoma↗
PubMed1982

Trabecular carcinoma of the skin: further clinicopathologic and morphologic study.

We studied the clinical aspects of 30 cases of trabecular carcinoma of the skin. Twenty-three patients were followed up for more than one year. Trabecular carcinoma of the skin is often misdiagnosed as a metastatic malignant tumor. The average age at the time of diagnosis was 68 years; most tumors occurred during the seventh and eighth decades of life. Most initial lesions were located in the head, neck, and upper extremities. Lymph node metastases developed in 13 patients, three of whom eventually died of the disease. Local recurrence developed in ten patients, four of whom died of metastatic trabecular carcinoma. The overall mortality was five of the 30 patients. Three of the patients in whom generalized metastases developed also suffered from some other severe systemic disorder. Nearly half of the 23 patients are free of disease. Sweat gland differentiation was observed in two cases, which indicates that the cell of origin is a multipotential unit capable of both neuroendocrine and sudoriferous differentiation.

Adenocarcinoma↗
PubMed1981

Benign spindle cell breast tumor.

A distinctive, benign, spindle cell tumor of the breast is described. Three patients were men, the fourth a woman. Histologically, each tumor displayed islands of spindle or stellate cells embedded in a collagenous matrix. Within the female breast, the lesion was within the stroma, displacing but not including the epithelial elements. Ultrastructural study of two tumors revealed diverse populations composed of fibroblasts, myofibroblasts, smooth muscle cells, and undifferentiated mesenchymal cells. The relationship of these tumors to spindle cell lipomas is discussed. The lesions have all been clinically benign, and their recognition as such is important.

Aged↗
PubMed1981

Carcinosarcoma of the uterine cervix: a light and electron microscopic study.

A case of carcinosarcoma of the uterine cervix is presented. Light microscopic and ultrastructural features of the tumor are described. While the epithelial component had the appearance of a carcinoma arising from endocervical epithelium, the stromal component was composed of malignant smooth muscle cells together with some cells having the charactristics of malignant fibroblasts. The tumor is considered to arise from the müllerian tract mesoderm and to be part of the spectrum of tumors which range from the totally benign adenofibroma to the malignant heterologous mixed mesodermal tumor.

Carcinosarcoma↗
PubMed1981

Multifocal malignant pheochromocytoma presenting as a lung tumor.

An unusual case of pheochromocytoma, which presented as a primary lung tumor, is described. The tumor was multifocal, arising in both the adrenal glands and in the chromaffin tissue around the thoracic aorta; it had invaded the lung and metastasized to the brain. Histologically the tumor had an unusual sarcomatous appearance, and the final diagnosis depended on the ultrastructural finding of scanty amounts of neurosecretory granules, typical of epinephrine and norepinephrine. This is the first reported case of pheochromocytoma presenting clinically as a lung tumor.

Adrenal Gland Neoplasms↗