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Biomedical subjects

C Thiel

Publications and source records attributed to C Thiel.

62 records · Page 4Linked to original sources

[Frequency and correlative relation of diagnostic criteria in animal dander allergy].

355 out-patients with signs of bronchial asthma were studied with special reference to animal dander sensitization. Case histories allowed the clinical diagnosis of an allergy to animal dander in 75 patients (21.1%). Skin testing is a useful means, as large reactions appear in most cases of animal dander allergy (60.7% are greater than or equal to + + + -reactions). Skin reactions, however, often are "false positive" or "false negative". Therefore, bronchial provocation tests are necessary if the case history is doubtful and/or the skin reaction is less than a + + + -reaction. There is a positive correlation between skin reaction and bronchial provocation test. No negative inhalation tests were seen when the skin reaction was greater than + + +. However, a positive inhalation test can be correlated with a negative or weakly positive skin test. The probability of common structural properties of different mammalian dander allergens is discussed. Avoidance of exposure to the animal is recommended as the therapy of choice.

Allergens↗

Oral cadmium exposure of adults in Germany. 2: Market basket calculations.

The cadmium intake of adults in Germany was calculated within the framework of market basket studies. Data were available on cadmium content of representative food assortments from 1988 and 1991. Food intake data were obtained within the second MONICA (MONItoring trends and determinants in CArdiovascular disease) survey 1988 and the nutrition survey in the new Federal lands 1991/92. Combining both data sets, an average cadmium intake of adults was found to be in the range 10-14 micrograms/day. This cadmium intake is 16-19% of the Provisional Tolerable Weekly Intake (PTWI) for cadmium and a toxicological risk from orally consumed cadmium can be excluded. The results were comparable to literature values. Cadmium intake was higher in men than in women owing to their higher food consumption. No differences were observed between cadmium intake in 1988 and 1991. The relative contribution of different food groups to cadmium consumption amounted to: bread, cake and pastries, 41%; potatoes, 14%; vegetables, 10%; meat, sausage and fish 9%.

Adult↗

Micro and macro perspectives in auxology: findings and considerations upon the variability of short term and individual growth and the stability of population derived parameters.

The present paper links the two most contrasting aspects of auxology, and addresses the apparent discrepancy between the variability and pulsatility of short term individual growth, and the stability of population derived parameters. When body stature is measured at monthly intervals, an irregular incremental pattern becomes obvious, with a number of large scale components such as series of prepubertal and pubertal growth spurts, seasonal influences on height gain, and influences of the psychosocial and economic background. When measurement intervals decrease, the patterns of stature increment appear even more irregular, and a number of short scale components become apparent, that are distinct from measurement error. Observations are presented that suggest growth being a pulsatile, a periodic, a saltatory, respectively a chaotic event as suggested by some recent studies in animals and in human newborns. Accurate measurements of the lower leg at intervals of 24 hours support the idea of short term growth being characterized by chaotic series of 'mini growth spurts' that occur at intervals of approximately 4-9 days. The amplitude of mini growth spurts ranges between 2 and some 10 mm, and also growth velocity of each spurt varies considerably so that one spurt needs between less than one and up to several days for completion. The very opposite of the variability of individual growth was found in populations. A meta-analysis of 40 male and 51 female European and US American growth studies revealed an almost uniform general pattern of average stature increment during the last 100 years. An additional analysis of stature variation of very large Japanese and Czechoslovakian growth surveys, with all together more than 23000000 measurements, and more than 500000 German preschool and school measurements, suggested similar uniformity in the standard deviation of stature.

Animals↗

Nutritional behaviour differences in Germany.

East- and west-German health inequalities that emerged in the 1960s and 1970s centered not only on cardiovascular mortality but also on lifestyle-dependent risk factors, thus a question that should be addressed is whether different dietary behaviours existed in the two sections of Germany. To answer this question, we examined two random-sample population surveys--MONICA in the east and VERA in the west--that were carried out during the late 1980s. In the eastern section of Germany, the consumption of milk, vegetable oil and fat, fresh vegetables and tropical fruits was much lower than that in the west, whereas the intake of sausages and butter was much higher. Consequently, the calorie intake in the east was higher for fat and lower for carbohydrates before reunification. Changes in dietary habits were anticipated in East Germany after reunification because of important changes in the food supply. Analysis of an east-German dietary survey that was carried out after the wall came down revealed that the improved food supply to the east, with more choices for planning a healthy diet, led to a favourable development in both macro- and micro-nutrient intake, more carbohydrates, vitamins, calcium, and potassium were consumed.

Adult↗