Biomedical subjects
Publications and source records attributed to C T Ashworth.
Liposarcoma of the spermatic cord is rare and easily masquerades as a more common benign neoplasm of the spermatic cord. If neglected, these malignancies may grow to tremendous size and become formidable management problems. The treatment of this malignancy is orchiectomy and en bloc removal of the tumor. More radical operative therapy has not generally proved beneficial. Adjunctive therapy may be helpful in selected cases.
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This report describes the use of a word-processing micro-computer, the Lanier Text Editor, for preparation of surgical tissue reports. Gross and microscopic description formats are stored on floppy disks, which may easily be completed and edited on a cathode-ray tube (CRT) for rapid computerized printing. Also described is the use of a PDP 8/E mini-computer for entry, storage, and manipulation of historic, demographic and diagnostic data, printing of numeric and alphabetic listings, cross-indexing of cases by diagnosis, and the accumulation of data for direct patient or physician billing.
A computer software package written in Dibol for a PDP 8/E computer is described that is designed for the needs of the cytology department of a moderate-sized private medical laboratory. Computerized accessioning of cases, report preparation and printing, historical filing, activity summary reports, and direct patient and physician billing are provided by the relatively inexpensive system. The software has been in use for over two years in our cytology department and has resulted in increased efficiency, cost-effectiveness, and quality of reports.
The volume of laboratory and other data that physicians encounter daily is more than most can mentally process without oversight or error. Routine use of computer-generated reminders is one solution to this problem that is now widely suggested. We report our experience with the daily use of a user-written program of algorithm-derived, computer-generated comments in the reporting of chemical profiles and routine thyroid function tests in a busy medium-sized privately owned independent clinical laboratory.
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In vitro micellar solutions of oleic acid, monoolein, and sodium taurocholate were studied electron microscopically. They contained osmiophilic particles 30-200A in diameter. Osmium staining alone was sufficient to demonstrate the particles; lead staining had little effect on their appearance. The intestinal intraluminal contents from rats during the absorption of unsaturated fat also contained osmiophilic particles, 40-200A, and numerous similar particles were found between the microvilli and engaged in the fine filamentous coating of microvilli. In the lumen only, larger emulsion-type droplets were also seen. The small particles were demonstrable in osmium-fixed material, with or without lead stains, and staining with lead only increased contrast of the particles. Spherules measuring about 1000A in diameter with walls about 100A thick were observed in the terminal web during fat absorption, at which time they were slightly larger and more numerous than in fasting rats. It is proposed that during fat absorption micellar particles are engaged in the filamentous material covering the microvilli and then enter the absorptive cell either by molecular diffusion across the plasma membrane or by being incorporated into the walls of thick-coated spherules which then pass into the subapical cytoplasm.
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