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Biomedical subjects

C Sutton

Publications and source records attributed to C Sutton.

77 records · Page 5Linked to original sources
PubMedDate not supplied

The relationship between pain and depression in a trial using paroxetine in sufferers of chronic low back pain.

Previous studies have shown a positive association between pain and depression, though evidence supporting a direct link between these two variables is less robust. Using a placebo-controlled trial, the authors examined the analgesic and antidepressant efficacy of paroxetine (20 mg) in chronic low back pain sufferers. The authors examined the associations among pain, depression, disability, and illness attitudes. Paroxetine showed no effects on pain or depression compared with placebo; however, subjects randomized to paroxetine were more likely to reduce concomitant analgesic medication. The cross-sectional association of depression and pain at baseline (r = 0.2, P = 0.02) was weaker than the association between depression and disability (r = 0.3, P = 0.004). Similarly, the association of change in depression scores with change in pain (r = 0.25, P = 0.016) was weaker than change between depression and disability (r = 0.49, P<0.0005). Whereas the relationship between pain and depression became nonsignificant when disability and illness attitudes were controlled, the relationship between depression and disability remained highly significant when pain and illness attitudes were controlled. These data are consistent with the association between pain and depression being wholly modulated by disability and illness attitudes, with no direct relationship between pain and depression.

Adolescent↗
PubMedDate not supplied

A titanium-nickel alloy intravascular endoprosthesis. In vitro studies.

In order to evaluate the implantation technique and reliability of conversion at different temperatures, a miniaturized intravascular endoprosthesis (IVEP) composed of thermal shape-memory effect TiNi alloy was delivered via a catheter into a 37 degrees C water mock circulatory loop (MCL) with a flow of 100 ml/min. The 2.5 mm diameter wire coil IVEP was torsion reduced to 1.4 mm, mounted on a modified balloon angioplasty catheter, and delivered into the MCL. Shape-memory conversion was activated thermally by injecting normal saline (3, 5, or 10 ml) at 45 degrees, 50 degrees, 55 degrees, 60 degrees, 65 degrees, or 70 degrees C, while the local temperature (Tp) at the endoprosthesis site was monitored by a thermocouple. Inconsistent completed conversions of the IVEP were produced by injecting 10 ml of 60 degrees C, or 5 ml of 65 degrees C normal saline, which raised the Tp to 45 degrees to 53 degrees C. Complete conversion of the IVEP to 2.5 mm was produced consistently by injecting 10 ml of 65 degrees C or 5 ml of 70 degrees C saline, which raised Tp to 55 degrees C for less than 1 sec. This moderate Tp (55 degrees C) for such a short duration was shown to be a reliable method for remote conversion of the IVEP after catheter delivery. Knowledge of the minimum temperature and volume for consistent, complete conversion of the IVEP has permitted simple, safe conversion during in vivo studies. Delivery after balloon angioplasty is envisioned to either treat acute dissection with occlusion or to prevent chronic restenosis, in order to further improve the safety and efficacy of balloon angioplasty procedures.

Alloys↗
PubMedDate not supplied

Subtotal hysterectomy revisited.

The advent of laparoscopic surgery has enabled gynaecologists to re-evaluate the traditional approaches to hysterectomy. Until the 1940's hysterectomy involved retaining the cervix because the simpler operation avoided damage to the ureter and prevented ascending infection, which was an important consideration before the advent of antibiotics. In order to reduce the risk of developing cervical carcinoma the cervix was traditionally removed at hysterectomy over the last 50 years. Since it is possible to remove the area where cervical carcinoma develops and with the development of an effective screening programme for cervical carcinoma, this needs no longer to be a consideration. A more logical approach to laparoscopic hysterectomy would be to retain the cervix but remove the transformation zone and in so doing there is less risk to the ureter, less postoperative urinary dysfunction, virtually no disturbance to the lower genital tract, thus resulting in little or no impairment of sexual enjoyment.

Cervix Uteri↗
PubMedDate not supplied

Operative laparoscopy.

The past decade has witnessed a transition from classic surgery to minimally invasive surgery through multiple small incisions under endoscopic vision. Although these operations present many technical difficulties and often take longer, they usually reduce the hospital stay and allow earlier return to full activity.

Female↗