Biomedical subjects
Publications and source records attributed to C Stefan.
The authors show that the variations of intraocular hyper- and hypotension stand for a reserved prognosis in the evolution of the operated retina detachment. Likewise, they consider that the repeated operations in the retina detachment may lead to the syndrome of anterior ischemia, unfavourable to the visual function.
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The effect of chronic biparental preconceptional alcoholization followed by alcohol consumption during the preimplantation period on the maternal and fetal homeostasis of some alkaline and alkaline-earth metals was studied in albino rats. Female and male rats consumed 20% ethanol (v/v) for 50-60 days before mating (group E). Further on pregnant females were alcoholized until day 5 of pregnancy. Control females and males consumed tap water (group C). Animals were sacrificed on day 20 of pregnancy. Blood samples were obtained from fetuses (the blood of each litter being pooled) and from pregnant females. Biochemical determinations were made by atomic emission spectroscopy for Na and K and by atomic absorption spectroscopy for Ca and Mg. Early and late mortality of conceptuses were checked. Non significant changes were observed within group E in the maternal serum as to Na (increase) and K(decrease), while Ca and Mg showed a significant decrease. Similar changes were found in the pooled fetal serum, the decrease of K and Mg being less marked. No structural anomalies were detected. With respect to tanatogenesis, both early resorptions and late fetal death were increased.
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In 28 chromatin-positive patients distributed into age-decade lots, the circulating levels of gonadotropins as shown by radioimmunoassay (RIA), were higher than normal. FSH was especially high while LH had significant fluctuations between the lots. A hypothalamic determinism for these anomalies is suggested.
A study carried out on 206 bacteriemia infections showed that: the following bacterial flora was implicated in the etiology of bacteremia infections: Staphylococcus aureus in 28.6% of cases, Staphylococcus albus in 20.4% Enterobacteriaceae in 25.7% and Pseudomonas in 3.8%; an increase existed in the number of generalized infections caused by opportunists belonging to the Enterobacteriaceae family and Pseudomonas genus. Similarly, an increase in the resistance to the recently introduced antibiotics, Septrin and Gentamycin, was noted. These observation require antibiotic lebel control and, if it is necessary the association of two or more antibiotics in severe infections.
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Following an introduction on the question of pseudocholinesterase (CHE) in cirrhosis of the liver and acute and chronic hepatopathy, a personal study of 35 chronic cases at various stages of the disease is reported. The patients were submitted to the usual haematochemical liver function tests as well as to liver needle biopsy with anatomo-functional staging of the liver trouble, which was largely due to alcohol poisoning. The CHE level in these patients was monitored until death. On the basis of the results, measurement of CHE is identified as an index not only of liver function (this is of course well known) but of prognosis infausta, there being a confirmed correlation between survival and CHE serum level.
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The paper presents a synthesis of today's means for differential diagnosis between symptomatic and idiopathic retinal detachment, considering that the retinal detachment remains an ocular emergency, with high invalidity potential. The characteristic difficulties of this diagnosis are also detailed. The different medical attendance of the two types of retinal detachment requires a rigorous differential diagnosis, according the leading part to the ophthalmological examination. There are also illustrated up-to-date diagnosis tests, less invasive and more informative, such as: CT and MRI. The survey highlights the value still relative of the majority of these investigations and the fundamental significance of the histological examination.
The paper presents the observations on a case of drusen of the optic nerve head associated with bird shot retinochoroidopathy and Cacchi-Ricci syndrome on a 45-years-old patient. The drusen of the optic nerve head and the birdshot syndrome are diseases of unknown etiology, with low frequency of appearance. They are often seen in individuals with perfectly normal vision (diagnostically these lesions have to be found on occasionally ophthalmoscopic examinations). Therapeutically, there is no restorative treatment. This association of drusen of the optic nerve head, bird shot retinochoroidopathy and Cacchi-Ricci syndrome hasn't been mentioned in the medical literature.