[Respiratory functional changes caused by the effects of various dust concentrations].
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Adult↗
Biomedical subjects
C Simionescu
Publications and source records attributed to C Simionescu.
[Considerations on the Salmonella species identified in the laboratory of the State Sanitary Inspector of the Jassy region in the period 1962-1964].
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Humans↗
[Hemorrhagic glaucoma].
The hemorrhagic glaucoma defines a clinical syndrome which recognizes as a frequent symptoms the hemorrhagic element, and from the morphopathological point of view the presence of some neoformation vessels at the level of the iris and camerular angle. 22 clinical observations of hemorrhagic glaucoma which appeared during one year are analyzed. It is shown that the new vessels appear as a reaction of the tissues hypoxemia and especially to alon of the oxygen pressure that determines the increase of the vessels. Also in the hemorrhagic glaucoma appears a deficiency of the venous reaction which determines a deficiency of the venous flow. The new vessels appear because of the hypoxemia and acid lactic accumulation only as the presence of a vital iridian tissue, because the new vessels do not appear in necrotic tissues.
Eye Hemorrhage↗
[Persistence of the primordial vitreous body and buphthalmos].
Persistence of the hyperplasic primordial vitreous body is determined by a deletion of embryonal development of the vitreous body and of the hyaloid vascular system. Infant aged 3.5 years presents persistence of primordial vitreous body with crystalline dislocation in the camera aquosa and secondary buphthalmos of the left eye and microphthalmos with dislocation of the crystalline in the vitreous body of the right eye. At the back of the right eye we noticed a whitish mass, richly vascularized with vestiges from the hyaloid artery, but the posterior half of the vitreous cavity is filled with microscopic blood; the fibrovascular membrane is made of conjunctive tissue set in parallel layers and vessels with macrolipophagic degeneration. Microscopic investigation of retina reveals glial hyperplasia zones in the neighbourhood of the vitreous body. In the present paper the authors show the persistence of the primordial vitreous body in the left eye and bilateral dislocation of the crystalline, revealing multiple ocular malformations.
Child, Preschool↗
[Giant-cell retinal dysplasia in microphthalmos].
Six-year-old girl presents unilateral moderate microphthalmos. After enucleation ocular histopathological exam shows multiple ocular structures anomalies at both anterior and posterior poles; the most important anomalies were localised at the level of retina, vitreous, and iridocorneal angle, and they were represented by retinal dysplasia with giant cells, persistence of the primitive vitreous, congenital cataract, Rieger syndrome.
Abnormalities, Multiple↗
[The ultramicroscopic aspects in malignant choroidal melanoma].
The survey focuses on the observation using the electronic microscope of two cases of uveal malignant melanoma. The ultrastructure of the cellular population which from this type of malignant tumour was followed, mentioning both the common and the particular aspects. The nuclear and nucleolar modifications, indicating an increase degree of atypia for the epithelioid cells compared with the fusiform cells, were observed. Some aspects of the abnormal tumoural cells were also emphasized. We noticed in the structure of the tumours, besides the tumoural cells, another structure of non-tumoural macrophage and reticular cells, and we described their ultrastructure.
Cell Nucleolus↗
[Embryonal rhabdomyosarcoma of the orbit].
The paper shows the case of a 19-years-old patient, who presented two month before the observation took place marked exophthalmos at the left eye with general state alteration. Computerised tomography pointed out a tumoral formation having 4 centimeters in diameter, which pushed off the anterior ocular globe, eroding to the left frontal lobe. The anatomopathological exam evidenced the embryonal rhabdomyosarcoma. So, every unilateral exophthalmos of the child or teenager must lead the diagnosis of embryonal rhabdomyosarcoma. The therapy consists of exeresis biopsy, followed by complex radiotherapy and chemotherapy. The orbital exenteration, a multilant intervention, does not guarantee for the further evolution of the affection.
Adult↗
[Epithelial tumors of the corneal limbus].
Corneal epithelial tumours are represented by intraepithelial carcinoma, invasive carcinoma and exceptional by melanic tumours with start point in intraepithelial melanocytes, 20 cases of epithelial tumours of epithelial limbus hospitalised in 3 years period, which represented 0.28% of patients, have been studied. Anatomopathological exam shows in 12 cases spinocellular carcinomas, in 2 cases basal cell carcinomas, in one case undifferentiated carcinoma in one case intraepithelial carcinoma and in 4 cases intraepithelial dysplasias. Limbus epithelioma is a very low penetrance tumour, the Bowman membrane being resisting and difficult to surpass. They have a great proliferative power. The tumour ablation with local diathermocoagulation was practiced, and postoperative contact radiotherapy has been done. In a single case a local recidive appeared and in another case the enucleation was practiced, because the tumour entered the ocular globe.
Adult↗
[The relationship of the lesions in choroidal benign nevus-malignant melanoma].
The paper presents the case of a 67-year-old female patient with an old posterior choroidal nevus, which has became malignant later. Microscopically, at the periphery of the malignant melanoma, long benign melanic cells are revealed, with nuclei centrally disposed and net cellular limits. The pigmentation of these cells, in parallel sequences of 4-5 rows each, is intense. The external part of the choroid, which has a regular aspect, is continued with B-type malignant cells. Finally, the origin of the malignant melanoma, derived from preexistent nevi, is discussed.
Aged↗
[Sympathetic ophthalmia in a case of neurilemmoma of the ciliary body].
The paper presents the case of a 62-year-old male patient, which has been hospitalized with the symptomatology of a acute glaucoma through intumescent lens. After the lens extraction, the globe evolution was to atrophy with chronic irrigation, starting a hypertensive cyclitis at the other eye, assumed to be a sympathetic ophthalmia. After several acute evolutive episodes at both eyes, the enucleation of the primal eye was made and a ciliary body tumour (neurinoma) was discovered. After enucleation under general and local cortisone treatment, the inflammatory phenomena at the sympathetic eye were entering in remission; but the hypertony, which was considered to be an open-angle pre-existent glaucoma, was persistent. The paper also discusses the sympathetic ophthalmia producing mechanism the characteristics of the ciliary body tumour and the diagnosis problems raised by this case.
Ciliary Body↗
[The morphological forms of malignant uveal melanoma].
They are presented the histopathological forms of the uveal malignant melanoma, its characteristics in electronic microscopy and also an attempt to correlate the histological type with the vital prognosis. They are reviewed the main classifications of this uveal malignant tumour, elaborated over time, and the criteria used for their establishment by the authors.
Choroid Neoplasms↗
[Epithelial-cystic nevus of the conjunctiva (Parinaud's dermo-epithelioma)].
The epithelio-cystic nevus of the conjunctiva, initially improperly denominated by Parinaud dermo-epithelioma, is a dysplasia circumscribed at the level of bulbar conjunctiva, characterized by its forming of epithelial cysts which develop in a base layer made of nevoid cells. This affection evolves by forming epithelial cysts mostly muciparus ones, when the tumor is sited rather far from the limbus, where multiple chaliced cells are to be found in the epithelium, and as simple epithelial cysts, mostly in the epidermis, when it is sited near the limbus where chaliced cells are scarcer. In this condition the setting of the epithelial compound takes the form of full lobules. The nevoid compound represents the capital element which establishes the diagnosis. The epitheliocystic nevus of conjunctiva is a benign dysembryo with excessive development of epithelial cells in a basic layer of nevoid cells. This affection is benign, but its morphologic diversity and its many denominations give rise to periodical debates.
Carcinoma↗
[Invasion of the optic nerve in undifferentiated retinoblastoma].
The case of a 2- and a half-year-old child is presented. The diagnosis was left-eye retinoblastoma and the left-eye enucleation was done. The anatomic-pathological exam emphasizes a microscopic structure of undifferentiated retinoblastoma, with the invasion of the optic nerve. After about 11 months, the child came again, presenting a tumoral mass which occupies almost entirely the orbital cavity, and also an altered general status.
Child, Preschool↗
[Malignant palpebral tumors. Comments on 111 cases].
During 1991-1995, 111 patients with palpebral malignant tumours were hospitalized. They represented 15% of the face malignant tumours. The maximal incidence was mentioned after the age of 60 years, only 21 patients were under 60 years of age. The most cases (88) were located at the level of inferior eyelid and internal canthus. From an anatomo-pathological point of view, 88 cases were baso-cellular epitheliomas, 10 were spino-cellular epitheliomas. 1 case was malignant melanoma and 1 case was adenocarcinomas of Meibomius gland. In 30% of the cases the patients come lately. The surgery of palpebral neoplasm requires both an oncological-oriented operation and a plastic-reparatory operation; the reparatory operations using free or pedicled grafts [correction of pediculate graphs] are presented.
Adult↗
Histopathologic aspects in endometrium dysplasias.
The paper presents a study consisting of 87 cases of endometrial hyperplasias. Histopathologic examination allowed us to identify the singular glandulo-cystic and adenomatous hyperplasia and the coexistence of the two lesions, but also the association (for two cases) of chronic adenomatous hyperplasia to endometrial carcinoma. These aspects plead for considering hyperplasia as a precancerous lesion taking into account the physiological stage when it appears.
Endometrial Hyperplasia↗
[Can chronic impregnation of human adipose tissue with organochlorine insecticides constitute a risk factor favoring the appearance and development of atherosclerosis?].
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Adipose Tissue↗
Pseudoepithelimatous hyperplasia positive and differential diagnosis.
Our study intended to describe some inflammatory and tumoral lesions associated to pseudoepithelimatous hyperplasia. In our casuistry, pseudoepithelimatous hyperplasia was determined by tuberculosis in two cases, granulomatous ulcerate epuils in 4 cases, myoblastoma in one case. Recognising these lesions is very important, since it helps differentiating between these tumors and some epidermal carcinomas, the two affections involving different therapies.
Adult↗
Remarks on some cases of stromal hyperplasia and endometrial sarcoma.
Our study works out different aspects which can appear both in stomal hyperplasias and endometrial sarcoma. It is possible to recognise histopathologic varieties of the stromal hyperplasias by a close co-operation with the gynaecologist. The necessity of a right diagnosis for all the forms of stromal hyperplasia spreads from the significance of precancerous lesion of some of them. We also mention the difficulties of diagnosis risen by stromal hyperplasias and endometrial sarcoma and also the necessity of a certain diagnosis having into consideration the prognostic and the different therapy imposed by the two diseases.
Adult↗