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Biomedical subjects

C Simionescu

Publications and source records attributed to C Simionescu.

At least 19 recordsLinked to original sources
PubMed1998

[The extension of retinoblastoma into neighboring structures].

Fourteen cases with retinoblastoma has been histologic studied. In eleven cases of them has been observed the invasion in the neighbour structures following the tumoral mass development: four cases in the vitreous, one case in the vitreous and the choroid, sclera and the optic nerve, one case in the vitreous choroid and optic nerve, two cases in the optic nerve. The tumoral invasion in the neighbour structures was observed only at the undifferentiated retinoblastoma.

Child, Preschool↗
PubMed1997

[Recurrent palpebral keratoacanthoma].

One female patient in seventy-four years old presents one hyperkeratotic neoformation which covers upper eyelid, external canthus, lower eyelid in external part and palpebral fissure of the right eye. The affection appeared fifteen years ago. The extirpation was made eight years ago, relapsed and established one corneal ulcer. Extirpation of tumoral formation first of deeper eyelid and than of lower eyelid with cutaneous free skin graft it practised. Anatomopathological exam confirms the diagnosis of keratoacanthoma with acanthosis, hyperkeratosis and dyskeratosis of pluristratified epithelium. The basal membrane, is preserved, but it is masked here and there by an discreet chronic inflammatory process. It insists over the differential diagnosis with spinocellular epithelioma, the patient remaining in observation.

Aged↗
PubMed1997

[Adenocarcinoma of Moll's glands].

A Moll gland adenocarcinoma case is presented. The female patient was 47 years old and the affection was localized at the inferior eyelid. The histopathological exam shows the presence of intense eosinophil cells with gland-shape disposition. The histopathological exam was necessary both for the diagnosis and for the establishment of the degree of differentiation of the tumour, emphasizing the extension of infiltration localization for the neighbouring structures.

Adenocarcinoma↗
PubMed1997

[Anatomicopathological studies in retinoblastoma].

For a fifteen-years period it has been examined fourteen cases with retinoblastoma, twelve of them have been undifferentiated forms and two cases differentiated forms in rosette, in undifferentiated retinoblastoma has been observed low size cells with poor cytoplasm and big nucleus that occupied near the whole cell; the nucleus to cytoplasm ratio is increased. The cellular density is irregular and most important perivascular. The tumoral parenchyma is condensed in perivascular areas, the tumoral stroma is poor, amorphous or mucinous. The necrosis areas are frequently but very import out in undifferentiated retinoblastoma. The tumoral vascularity is increased. In some cases occur melanin pigment that belong to the pigment epithelium without the existence of tumoral proliferation.

Child, Preschool↗
PubMed1986

Bioactive polymers XXXIII. Synthesis and evaluation of some pharmacological characteristics of chloramphenicol immobilized on Biozan R.

The coupling of chloramphenicol on Biozan R (Hercules) by activation with dicyclohexylcarbodiimide was studied. The esterification is influenced by the chloramphenicol/dicyclohexylcarbodiimide ratio, concentration of the reactants and reaction time. The Biozan R-chloramphenicol system containing 15% chloramphenicol was used to obtain ophthalmic ointments. They were studied from the point of view of their physicochemical and biological properties. Tests were performed on animals and volunteers to establish the ophthalmic tolerance; some clinical observations on treated eyes were also made.

Animals↗
PubMed1977

Synthesis of purine and pyrimidine bases and nucleosides under the cold plasma conditions (IX).

Living-matter precursors are obtained by the action of the high-frequency electrical discharges on a methane-ammonia-water mixture. Some purine and pyrimidine bases as well as nucleosides are detected and estimated quantitatively by column chromatography, one- and two-dimensional paper chromatography, paper chromatography with standard addition, colour tests as well as by optical density measurement within the UV region.

Ammonia↗
PubMedDate not supplied

[The invasion of neighboring structures in malignant choroid melanoma].

It has been followed the microscopical evolution of the malignant melanoma of the choroid. After a stage of local growth, often with necrosis and intratumoral haemorrhages, it invades the neighbouring structures. The invasion of retina is produced at the apex level, making a breach in Bruch's membrane, the tumour becomes likewise a dumb-bell, a mushroom or a clepsydra. When the tumour is in contact with the retina, it produces a proliferation of pigmentary tumoral cells, glial cells and lymphoplasmocytary inflammatory reaction, which emphasize the sensorial retina detachment. The sclera invasion takes place especially in plaqued melanoma, through the points of minimal resistance which are the nervous routes, breaking up the scleral structures. The appearance of rudimentary vessels, with tumoural cells in lumen, constitutes a serous prognostic because of tumoural embolisms.

Bruch Membrane↗
PubMedDate not supplied

The coexistence of atypical intraductal hyperplasias with breast carcinoma.

We present a study made during 4 years (1992-1996), which pursued the underlining of the atypical intraductal hiperplasias (A.I.D.H.) lesions, met isolated or in the association with mamar carcinoma. Our study included a 188 number of the breast tumors, among: in the 23 cases we established the existence of the modification by the A.I.D.H, type at the fibrocystics disease associated or not with the other benign diseases of the breast (fibroadenosis, intraductal papiloma) and in the 63 cases there were the modification by the AIDH associated with in situ or invasiv carcinoma. Epithelial hyperplasia is frequently associated with the fibrocystic changes, being included in the category of fibrocystic or proliferating modifications. The synonymous terms used for the epithelial hyperplasia are the hiperplazia ductala, or the epitelioza, or the papilomatosis The last two are suggested by the proliferation possibility (papillary or linear) of the epithelial or the mio-epithelial cells. Regardless of the microscopic aspect of the lesion, that should be acknowledged and treated as it is, due to the increased risk of the development of a carcinoma later on, and also due to the ratio of association between the modification and the mammary carcinoma. The risk of occurrence of subsequent carcinoma is augmented in the presence of the epithelial atipii and also increases in the presence of a mammary carcinoma at the relatives of the first rank (1.3). In this context, the importance of the differential diagnosis between the simple intraductal hyperplasia and the atypical one, the difficulty of differentiation from intraductal carcinoma in some cases, and finally the association with an increased risk of subsequent occurrence of carcinoma, constitute into sufficient arguments to consider this topic separately.

Adenocarcinoma↗
PubMedDate not supplied

Positive and differential diagnosis in a case of mucinous ovarian cystadenocarcinofibroma.

We present the case of a 50-year old patient with left tumoral pelviabdominal formation of the size of a foetus head. The histological study performed on sections from different areas of the tumour enabled the establishment of the diagnosis of mucinous cystadenocarcinofibroma of enteroid type with undifferentiated mucipar areas with ring in seal. The contralateral ovary was unaffected.

Cystadenocarcinoma, Mucinous↗
PubMedDate not supplied

The immunohistochemical profile of luminal epithelial neoplastic component from pleomorphic adenomas of salivary glands.

The immunohistochemistry study made on 30 cases of salivary glands pleomorphic adenomas aims to establish the antigen profile of luminal epithelial neoplastic component proliferates into these tumors. We ascertain that luminal epithelial neoplastic cell were almost exclusively positive to antibody peculiar to epithelial differentiation (AE1/AE3, MNF 116, CK 8, CK 19, CK20, EMA) and occasional to S-100 protein and negative to vimentin, alpha-smooth muscle actin, calponin, Glial Fibrillary Acidic Protein (GFAP). This kind of immunoreactivity was similar to ductal cells from striated channels of salivary glands, suggesting the origin of such pleomorphic adenomas from this place.

Adenoma, Pleomorphic↗
PubMedDate not supplied

Value of immunohistochemistry in confirming undifferentiated ovarian carcinomas.

The present immunohistochemical study was carried out on ten cases of ovarian tumours diagnosed with usual staining as undifferentiated ovarian carcinomas. A panel of antibodies was chosen in order to confirm the epithelial origin of these tumours and to eliminate some possible ovarian metastasis. The cytokeratin AE1/AE3, EMA and BerEP4 positivity supported their epithelial origin even if thirty per cent of the cases co-expressed cytokeratin and vimentin. Even if there is not a specific marker to confirm the ovarian origin of the tumours, the CA125 and CEA positivity suggested that these carcinomas might represent a serous or a mucinous dedifferentiation. Associated with these antibodies, the calretinin, CK7 and CK20 stainings allowed the separation of these tumours from peritoneal mesotheliomas with ovarian extension and from ovarian metastasis originating in the gastrointestinal tract. The evaluation of the PCNA labelling index confirms the high degree of cell proliferation and the aggressiveness of these tumours.

Biomarkers, Tumor↗
PubMedDate not supplied

Histopathologic and immunohistochemical study in one case of cystadenoma of parotid gland becoming malignant.

Cystadenoma and cystadenocarcinoma of the salivary glands are rare tumors, approximately half of cases being diagnosed at the level of parotid. The studied tumor associated both benign and malign zones, with deep infiltrating character in the adjacent structures. In both areas the growing pattern was predominantly cystic and papillary, and the proliferated neoplastic cells were majority cubical or columnar, with low grade of nuclear pleomorphism in the becoming malign areas, discordant with the infiltrative character of the neoplasm. Immunohistochemically, we investigated the tumor with AE1-AE3, CEA, SMA, S-100 and PCNA.

Biomarkers, Tumor↗
PubMedDate not supplied

Histopathologic aspects in microglandular hyperplasia of endocervix.

In this study we analysed 373 cases of microglandular hyperplasia of endocervix belonging to patients from the III-VII decades of life. Most of the lesions had the typic aspect of proliferation of small glandular lumen lined by endocervix type epithelium, with or without areas of basal proliferation or immature squamous metaplasia. In 8 cases the growing patterns were peculiar, with mucinous or florid aspects, three of the cases rising differential diagnosis problems with cervical carcinoma.

Adult↗