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Biomedical subjects

C Schirren

Publications and source records attributed to C Schirren.

At least 73 records · Page 4Linked to original sources
PubMed1976

[Differential diagnosis of the Prom-standard-values-deviating spermiogram].

Critical remarks to some points of clinical relevance for differential diagnosis of the spermatogram are made. The following parameters of the andrological examination are discussed: testis volume, ejaculate volume, pH, consistency of the ejaculate, sperm density, sperm motility, sperm morphology, biochemistry of the human semen.

Androgens↗
PubMed1976

[Sterilization as a method of contraception. Results of consultations on the desire for vasectomy].

A prerequisite for medical agreement with the desire for vicarious sterilization of the male is the procedure which has become known as the Hamburg model, in which the discussion between doctor and the married couple assumes a pre-eminent role. The operation is performed by a second doctor who did not participate in the consultation and is consequently impartial. There is no accquiescence on the medical side if, for example, the marital situation must be considered as tense, if the ideas of the couple on the finality associated with vasectomy are aboslutely unsatisfactory, and if the decision as a partnership is expressly rejected and instead the freedom of the individual is given primary importance. Both partners must have the opportunity for repeated confidential consultation before the written agreement is signed.

Adult↗
PubMed1976

On the morphology of the human Sertoli cells under normal conditions and in patients with impaired fertility.

Sertoli cells in testicular biopsies from 7 patients with Sertoli-cell only syndrome, 8 patients who had been treated with cyclophosphamide for testicular neoplasia, 8 patients with oligozoospermia, 7 patients with cryptorchidism, and 8 patients with seminoma were examined under the electron microscope and compared with Sertoli cells of normal tissues. The investigations reveal that each of these conditions of impaired fertility is characterized of a special type of Sertoli cell. The cell pattern is either restricted to one or two of the normally occurring cell types, or modified cells predominate that might be typical of the underlying disturbances of spermatogenesis. It is suggested that the cell type which prevails in the Sertoli-cell only syndrome is capable of maintaining a basic production of a substance that inhibits FSH secretion.

Adult↗
PubMed1976

[Studies of acrosin and human sperm trypsin inhibitor activity in human semen. I. Relations to sperm density].

Report concerning the sperm examination of 825 patients of the Dept. for Andrology. The acrosin as well as the human sperma trypsin inhibitor activity were investigated. The results were related to sperm density. It was found that acrosin activity was significantly dependent on sperm density. For the human sperma trypsin inhibitor activity this relationship could not be established, although lower values were found by sperm deficiency and higher values by high sperm density.

Acrosin↗
PubMed1975

Determination of sperm-antibodies in sera of sterile women by affinity-chromatography (affinity-chromatography of sperm-antibodies).

The total amount of humoral sperm antibody protein is determined following its isolation by affinity-chromatography on spermatozoa. Serum proteins are eluted by Sorensen phosphate buffer. Antibodies attached to spermatozoa suspended in Sephadex G 75 columns resist elution by Sorensen buffer. They can be quantitatively washed out by 8 ml Tris HCl-buffer pH 8,9 and be determined as proteins by the Folin-Ciocalteu method.

Adsorption↗
PubMed1975

[The present status of the treatment of male factors of infertility in barren couples with special reference to co-operation between andrologists and gynaecologists (author's transl)].

The interests of a barren couple are seen as the desire to obtain their own child with medical aid irrespective of the methodology of medical aid as long as there is success. At times quarrels over competency are an impediment to a coordinated treatment of the barren couple. At times treatment is thus precluded. A practical co-operation between andrologists and gynaecologists should be possible. It is important that the exchange of information is improved on the methods of investigation, on the interpretation of the tests results and on the plan of management for each partner of the infertile couple. Treatment of male infertility is not as hopeless as it is still portrayed. However one should not ask for the impossible of the treatment of male infertility since the most optimal seminal analysis result is useless in the presence of a monophysic menstrual cycle in the partner. The andrologist thrives for an improved differential diagnosis in order to select male patients who require treatment and in order to treat these more selectively. A single preparation for the treatment of all cases of male infertility does not exist just as much as a single preparation for the treatment of all menstrual anomalies in women does not exist.

Androgens↗
PubMed1975

[The correlation of morphological and biochemical factors in human ejaculate in various andrological diagnoses. I. Relationship between ejaculate volume, number, motility and morphology of the spermatozoa with regard to age].

This first report from a study conducted to determine correlations between morphological and biochemical parameters in human ejaculate presents the results based on the measurement of predominantly morphological criteria in patients of various clinical diagnosis groups. The allocation of the 525 patients, who were recruited into the study during the period 1972/73 in the Department of Andrology, Hamburg-Eppendorf, to the diagnosis groups normozoospermia (196), asthenozoospermia (92), oligozoospermia (181) and azoospermia (56) was performed in accordance with the Recommendations for Andrological Nomenclature (1970). The following data were evaluated for this report: height (cm), weight (kg), age (years), ejaculate volume (ml), number of spermatozoa (mill./ml), motility (percentage of highly motile, motile and non-motile spermatozoa), round cells (mill./ml), morphology (percentage of normal-shaped/pathological spermatozoa), changes to the head, middle and tail sections (percentage of the pathological spermatozoa). Relationships between a dependent biological variable (y) and a variable to be assumed independent (x) were obtained by adaptation of polynomials of the 3rd degree: y = b0 + b1 + b2x2 + b3x3. The coefficients (b) which did not differ significantly (p greater than 0.05) from zero were eliminated step by step in regression analyses with breakdown and the resulting mean curves within the ranges covered by the sample depicted graphically. For the time being, the relationships found are described only in the sense of a collection of material. The increased occurrence of pathological spermatozoa in advancing age together with lower values for highly motile spermatozoa could be regarded as a result of a lower organ effectiveness of testosterone, which is protein-bound to an increased extent with advancing age. At the present time there is no explanation for the larger numbers of spermatozoa found with increasing age. The positive correlation between higher sperm counts and high motility, and between high motility and a lower percentage of pathological forms corresponds to expectations from earlier studies. The number of changes to the head, middle and tail sections increase proportionally in keeping with an increasing percentage of pathological forms. When the changes to the head, middle and tail sections are placed in relationship to the diagnosis groups normozoospermia, asthenozoospermia and oligozoospermia a disproportional percental participation becomes noticeable.

Adolescent↗