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Biomedical subjects

C Sanchez

Publications and source records attributed to C Sanchez.

85 records · Page 5Linked to original sources
PubMed1978

Immunological diagnosis of echinococcosis.

Our results with the immunofluorescence technique in the diagnosis of hydatid disease are reported. The sera of 28 patients with surgically proven hydatid disease, of 30 healthy individuals, and of 1 patient with cysticercosis were used. With a dilution of 1:100 a sensitivity of 96% was obtained in the patients affected by the disease. In the control group all but one of the sera were negative. A brief review of the immunological methods used at present for the diagnosis of echinococcosis is made. The most important problems connected with the immunodiagnosis of this disease are discussed.

Adolescent↗
PubMed1978

[Spermatogenic dysfunction and gonadotrophins (author's transl)].

The authors try to demonstrate a relation between the number of immature cells of germinal origin in sterile men's sperm and plasmatic gonadotrophin levels of the same patients. Plasma FSH, LH, testosterone and 17 beta-estradiol were assayed in two groups of male patients with teratospermia. Results were compared with those obtained in a control group of normal men. Hypophyseal gonadotrophins level is higher in men whose spermatogenesis is defective than in normal men. It is suggested that these results might support the hypothesis that a defect in inhibin synthesis would be responsible for raised gonadotrophins.

Estradiol↗
PubMedDate not supplied

Varying responses to the rat forced-swim test under diurnal and nocturnal conditions.

The paradox that experiments in behavioural pharmacology employing nocturnal rodent species are carried out almost exclusively in the resting phase of the animals' circadian cycle has remained largely unexamined and unquestioned. This is despite the fact that all major physiological systems in the body are intrinsically aligned with its natural circadian rhythm. The forced-swim test (FST) is a rodent model that is used extensively as a screening test for antidepressant activity. The objectives of the present study were to examine the behaviour of rats in the FST under diurnal and nocturnal conditions and, in addition, to profile the response of neurochemical, neuroendocrine, and cellular indices of stress at time points up to 120 min following exposure to the FST. The time spent in escape-oriented activity was significantly less when animals were tested in the dark phase. The profile of serum corticosterone and adrenal ascorbic acid concentrations indicates that the animals were less stressed by the test situation during the active (i.e., dark) phase of their circadian cycle. Similarly, increases in blood enzymatic markers of stress-induced cellular damage were less marked following FST exposure in the nocturnal period. Characteristic stress-induced increases in 5-HT turnover in the frontal cortex and amygdala observed in the diurnal phase were reversed in the nocturnal period. In conclusion, circadian differences in behaviour in the FST may be related to parallel alterations in the ability of animals to adapt to exposure to stress.

Adrenal Glands↗
PubMedDate not supplied

Pulmonary manifestations of chronic liver disease.

Several lung disorders can occur as a consequence of chronic liver disease. In addition to the common findings of splanchnic and systemic vasodilatation in patients with chronic liver disease, pulmonary vasodilatation may also occur. This "hepatopulmonary syndrome' results in hypoxemia through pulmonary vasodilation and VA/Q mismatch, and in its advanced form leads to significant intrapulmonary arteriovenous shunting. Portal hypertension commonly results in the development of ascites, which may cause a restrictive lung pattern or pleural effusions. Rarely, thrombi formed in congested portal vein branches pass through portosystemic shunts and cause pulmonary hypertension, and plexogenic pulmonary hypertension may also occur in patients with portal hypertension. The autoimmune liver diseases, primary biliary cirrhosis and autoimmune hepatitis, may be accompanied by immune-mediated lung disease. These pulmonary abnormalities represent important extrahepatic manifestations of chronic liver disease.

Ascites↗
PubMedDate not supplied

Suspected extragonadal germ-cell cancer syndrome presenting with an orbital mass and elevation of serum CEA, CA 19-9 and CA50 levels.

Patients with extragonadal germ-cell cancer syndrome (EGCCS) represent a subgroup of patients with poorly differentiated carcinoma or adenocarcinoma of an unknown primary site for whom potentially curative therapy is available. We report the case of a young man presenting an orbital tumor and high serum levels of CEA, CA 19-9 and CA50 for whom an initial diagnosis of metastatic poorly differentiated carcinoma was made. Suspecting EGCCS, he was treated as for a germ-cell tumor. While in treatment, he underwent residual orbital mass resection, and the histologic diagnosis was embryonal carcinoma based on alpha-fetoprotein immunoperoxidase staining. We discuss the rare location at diagnosis, the impressive increase in the commonly considered gastrointestinal markers that he showed, and the potential utility of these markers for such patients.

Adult↗