Biomedical subjects
Publications and source records attributed to C Roux.
Four cases of balanced translocations with phenotype abnormalities are reported. Three of them are reciprocal translocation, one is a Robertsonnian translocation. The consequences of the phenomene on genetic counselling and prenatal diagnosis are discussed.
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Three observations of Wolf's syndrome (monosomy 4p) are reported and compared to the observations reported in the literature.
Sprague-Dawley rats are sensitive to the teratogenic action of AY 9944, an inhibitor of cholesterol synthesis, but the dose of inhibitor necessary to induce the same rate of characteristic malformations is twice as large for Sprague-Dawley as for Wistar rats. This variation is probably related to differences in levels of blood cholesterol in the strains and demonstrates a relationship between teratogenicity and metabolic disturbances.
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The taxonomic characters of 77 strains of Clostridium tyrobutyricum have been studied and compared to those of known strains. This work shows the insufficiency of the Bergey's Manual (8th edition) nine characters distinguishing Clostridium groupe I to identify C. tyrobutyricum. To be more representative of the species, addition of one or two characters to this key of determination and some modifications to the complementary description of C. tyrobutyricum in this manual are proposed.
The lytic activity of 132 phages isolated during slow acid production in cheese factories situated in all the dairying regions of France during the past 16 years has been determined on 291 strains of mesophilic lactic streptococci. The results have been treated according to a method of analysis of data so as to establish a classification. Six groups of phages have thus been formed. Sixty-six percent of the phages studied, which are very similar and for the most part nonspecific to one species, have been gathered together in one group. On the other hand, a classification of the bacterial strains has been made on their sensitivity to the phages. Six groups, each corresponding to one of these groups of phages, have thus been defined. One of them accounts for 40% of the strains studied, of which certain ones are sensitive to a large number of phages.
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The authors report the results of prophylaxis of congenital toxoplasmosis in a maternity hospital in Paris for a two years period (1973-1974). 6269 pregnant women were surveyed. 18 toxoplasmosis were detected in evolution at the first prenatal examination, 10 seroconversions were identified among the first examination antibody negative women, when re-examined during the pregnancy. 25 of these 28 women were treated regularly. The seroconversions of the 3 other women were detected only at delivery. In addition 25 women were treated because of high antibody titers (Dye-Test greater than or equal to 300. U.I/ml). 6 congenital toxoplasmosis, 2 of them were manifest, were observed among the children whose mothers were treated for confirmed toxoplasmosis. The extremely low level of seroconversions may be in relation to hygienic and dietetic prescriptions. The difficulties of this prophylaxis are analysed: they are due to studied population and to problems of interpretation or serologic examinations.
The effect of dietary deficiency during pregnancy of zinc or magnesium on maternal and fetal chromosomes was studied. Pregnant rats were given a zinc-deficient or a magnesium-deficient diet from the beginning of pregnancy and maternal bone marrow and fetal liver were removed on day 19 of gestation. Chromosome spreads were prepared and metaphases examined for abnormalities. Both magnesium- and zinc-deficient maternal bone-marrow and fetal liver cells showed significantly more chromosomal abnormalities than did those of controls. The chromosomal aberrations occurring in highest incidence in magnesium-deficient animals were terminal deletions and fragments. A higher than normal incidence of "stickiness" was also observed in cells from magnesium-deficient animals. In zinc-deficient animals, on the other hand, the chromosomal aberrations with the highest incidence were gaps and terminal deletions.
A case of in testitial deletion of the long arm of chromosome 11 associated with mild facial deformity, broad skull and mental retardation is reported.
The authors report the results of checking for toxoplasmosis in a maternity hospital in Paris in one year. 3,409 women were checked. 19 cases of toxoplasmosis were detected and treated. 4 of these were cogenital toxoplasmosis, of which 3 were obvious. We have to point out that sero-conversion did not occur during the survey after we had started to prescribe hygienic diets to patients in the survey. The difficulties accompanying this form of prophylaxis have been analysed.
The results of the effect of hypoxia or anoxia upon the rat neurohypophysis shows a decrease of the neurosecretory granules and the rise of the small vesicles.
Intake of tritiated thymidine by the embryos of Wistar pregnant rats treated by AY 9944 is significantly lowered. This decrease is parallel with the embryonic hypotrophy. Is there a causal relationship between the two phenomena?
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