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C Rose

Publications and source records attributed to C Rose.

At least 361 records · Page 20Linked to original sources
PubMed1976

[Wine substitutes].

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Alcoholic Beverages↗
PubMed1976

Neurochemical evidence for histamine acting as a transmitter in mammalian brain.

HA, besides its function in immune processes, is probably a neurotransmitter in mammalian brain. It is synthesized by a specific decarboxylase localized in the cytoplasm of nerve endings. It is stored in synaptic vesicles. Its release might depend on nerve-impulse flow; specific receptors to this amine have been evidenced both electrophysiologically and by the activation of cyclic AMP formation. Lesion studies indicate that histamine-containing neurons might constitute an ascending bundle arising from the brainstem and widely projecting into the whole telencephalon. This disposition, together with neuropharmacological data, suggests that histaminergic neurons, like the monoaminergic ones, might be involved in the control of arousal mechanisms, an idea consistent with the observed fluctuations of the endogenous amine content during the day-night cycle. On the other hand, the investigation of the effect of stress situations on the turnover of HA in brain leads to the conclusion that histaminergic neurons are specifically affected.

Animals↗
PubMed1975

Synthesis and release of histamine studied on slices from rat hypothalamus.

In slices from rat hypothalamus, incubated in the presence of 3H-L-histidine (3H-L-His), the aminoacid was rapidly taken up by a saturable process, and partially converted into 3H-histamine (3H-HA). The overall conversion was prevented either by inhibitors of L-histidine decarboxylase or by aromatic aminoacids competing with L-His uptake. The synthesis process exhibited Michaelis--Menten kinetics with an affinity of the aminoacid not different from that for the decarboxylase in homogenates; however the Vmax in homogenates was more than 10 times higher than in slices. Depolarization of the slices by 50 mM potassium resulted in: (a) a calcium-dependent release of 3H-HA which was more marked than that previously reported for endogenous HA, (b) a significant acceleration in the rate of 3H-HA synthesis, which was characterized by an unchanged Km but a significantly elevated Vmax. The regulation of HA synthesis did not appear to depend on end-product inhibition since it was not midified by the addition of exogenous HA. The release of 3H-HA was followed by the accumulation of 3H-methylhistamine, which was enhanced by a monoamine oxidase inhibitor. Aminoguanidine, a diamine oxidase inhibitor, had no effect on catabolism. The involvement of mast-cells in the storage of a fraction of endogenous HA in hypothalamic slices was assessed by the significant releasing effect of compound 48/80. Hence, the data support the existence of two distinct HA stores in the brain: depolarization relases the amine and increases its synthesis, probably in neurones, whereas compound 48/80 releases it from a slowly turning-over store, probably in mast-cells.

Amino Acid Oxidoreductases↗
PubMedDate not supplied

Dermatomyofibroma: case report and review.

This case report describes a 4-year-old boy with a dermatomyofibroma on the posterior aspect of the neck. Dermatomyofibroma is a recently described, rare, benign proliferation of myofibroblasts of the skin, mainly found in young women. Only a few cases have been reported in males. This entity is not generally well known and probably often misdiagnosed. To our knowledge the patient presented here is the youngest diagnosed thus far.

Child, Preschool↗