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Biomedical subjects

C Rose

Publications and source records attributed to C Rose.

At least 343 records · Page 19Linked to original sources
PubMed1980

Effects of an insertion mutation in a locus affecting pyridine nucleotide transhydrogenase (pnt::Tn5) on the growth of Escherichia coli.

The effects of a pnt::Tn5 insertion mutation on the growth of strains lacking phosphoglucoisomerase or glucose 6-phosphate dehydrogenase were examined. The results support the idea that the energy-linked transhydrogenase is an important source of reduced nicotinamide adenine dinucleotide phosphate for Escherichia coli under some conditions.

DNA Transposable Elements↗
PubMed1980

The radiologist, the patient and Canadian law.

A knowledge of basic medico-legal principles is necessary to the practice of medicine. The professional relationships with radiologists undertake with patients, employees, colleagues and hospitals are all founded on mutual consent and governed by a multitude of laws and regulations. The principal forms of legal proceedings which involve radiologists are criminal, civil and disciplinary actions. The discussion in this article is focused on the law relating to consent. The consent of the patient, which may be expressed or implied, is necessary in all phases of the doctor-patient reltionship. The amount of information which must be provided to allow a patient to give informed consent varies from case to case. It is affected by the risk and potential benefit of the procedure, the demand of the patient for information and many other factors. Obtaining informed consent not only helps protect the radiologist from legal action but also allows for a better doctor-patient relationship.

Canada↗
PubMed1980

Radiology and the law of negligence.

Canadian law expects all persons to behave reasonably in all phases of their lives. An individual who behaves reasonably has nothing to fear from the courts. The determination of what constitutes reasonable behaviour in medicine involves a common-sense approach to the rights and responsibilities of medical and non-medical members of the community. Every day thousands of Canadians trust Canadian radiologists with their lives and livelihoods. That trust demand no less care than the courts ask for. The meeting of this standard requires constant attention. Where there is prudence, forethought, and a good patient-physician relationship, there should be few negligence suits.

Canada↗
PubMed1979

Genetic mapping of a mutation affecting pyridine nucleotide transhydrogenase in Escherichia coli.

A mutation, pnt-1, causing loss of pyridine nucleotide transhydrogenase activity in Escherichia coli, was mapped by assaying for the enzyme in extracts of recombinant strains produced by conjugation, F-duction, and P1 transduction. The site of this mutation was near min 35, counterclockwise from man, and it co-transduced 59% with man. The mutation was associated with loss from the cell membrane fraction of energy-independent and adenosine 5'-triphosphate-dependent transhydrogenase activities, but reduced nicotinamide adenine dinucleotide dehydrogenase activity was not affected. Strains were constructed which lack phosphoglucoisomerase (pgi-2) and which carry either pnt+ or pnt-1. Although such strains, when grown on glucose, are expected to produce a large excess of reduced nicotinamide adenine dinucleotide phosphate, the growth rate was not affected by the pnt-1 allele.

Cell Membrane↗
PubMed1979

An assessment of the Alabama Smile Keeper school dental health education program.

An evaluation of the Alabama Smile Keeper Dental Health Education Program was necessary to determine if educating teachers to teach preventive dentistry improved the oral hygiene and knowledge of dental health of elementary schoolchildren. Four hundred seventy-five students at the Maxwell Air Force Base elementary school in grades 1 through 6 were tested using a series of written examinations and scores from a plaque index (Greene's OHI-S Index) before and after the education program. Levels of plaque were significantly reduced immediately after instruction and retention test scores were significantly lower four months later than preinstruction test scores. Written examinations proved that knowledge increased immediately after instruction and retention test scores were significantly better than preinstruction test scores.

Alabama↗
PubMed1979

Therapeutic effect of tamoxifen versus tamoxifen combined with medroxyprogesterone acetate in advanced breast cancer in postmenopausal women.

Postmenopausal patients, those less than 68 years of age resistant to chemotherapy and those greater than 68 years of age with or without resistance to chemotherapy, entered this trial. Among 101 eligible patients, 46 were randomized to treatment with tamoxifen at a dose of 10 mg 3 times daily and 55 were randomized to treatment with tamoxifen at a dose of 10 mg 3 times daily plus medroxyprogesterone acetate at a dose of 100 mg once daily. Remission (partial plus complete) was obtained in 20 patients (45%) with tamoxifen compared to 14 patients (26%) with tamoxifen plus medroxyprogesterone acetate; however, this difference is not significantly different. The median duration of remission was also not significantly different between the two treatments: 10 months for the single drug compared with 9 months for the combined treatment. Response rates correlated with the presence of estrogen receptor, with no differences between the two treatment groups. Side effects occurred in 12 patients and in only one patient did they cause discontinuation of treatment. In conclusion, these results and theoretic considerations indicate that combined treatment with tamoxifen and medroxyprogesterone acetate is not better than treatment with tamoxifen alone.

Adult↗