Biomedical subjects
Publications and source records attributed to C R Daniel.
Color changes of the nail unit may be innocent or may be associated with disease. Four tables provide the reader with a means of categorizing pigmentation abnormalities in the following manner: changes attributable to systemic disorders and some predominantly dermatologic conditions, changes caused by systemic drugs or ingestants, changes attributable to local agents, and changes attributable to some named nail entities.
Trauma to the nail folds can allow pathologic bacteria to invade this region. Once a primary, active infection has occurred in a nail fold, the area is often predisposed to chronic paronychia. Both chronic and acute paronychia are discussed, including their causes and treatments.
Nail abnormalities secondary to systemic disease are important to the dermatologist because they are readily examined and may be the initial signal that systemic disease may be present. Some of the abnormal nail findings represent part of a symptom complex that may be useful in physical diagnosis. The knowledge of the correct onychopathologic etiology may give the patient the correct nail prognosis and may prevent institution of possible incorrect lengthy and costly treatment regimens. In this article, nail signs are grouped according to the characteristics of the change and according to systemic diseases producing signs.
Systemic drugs or ingestants may affect the nails. Changes vary from asymptomatic growth rate changes and pigmentation abnormalities to nail shedding and permanent deformity. The former two changes are most common. Presented are changes in nails caused by antibiotics, cancer chemotherapeutic drugs, poisons and ingestants, antimalarial drugs, and miscellaneous drugs.
Systemic drugs often affect the nails. These changes range from mild pigmentation abnormalities to nail shedding and matrix scarring. The purpose of this article is to provide a handy reference for the physician who is confronted with nail disorders that may be due to systemic drugs or ingestants.
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The study of abnormal nails (onychopathology) can contribute considerably to the art of diagnostic medicine. Nail pigmentation is an important facet of onychopathology. Pigmentation abnormalities may suggest general disease and in some cases indicate a specific diagnosis. Their recognition may also be valuable in following the side effects of treatment.
The nail-patella syndrome has been of interest to dermatologists because the diagnosis of this multisystem complex may be suggested simply by observing the patient's abnormal nails. It is the purpose of this article to call attention to triangular lunulae and other nail abnormalities associated with this syndrome, as well as other causes of triangular lunulae.
The study of abnormal nails (onychopathology) can contribute considerably to the art of diagnostic medicine. Nail pigmentation is an important facet of onychopathology. Pigmentation abnormalities may suggest general disease and in some cases indicate a specific diagnosis. Their recognition may also be valuable in following the side effects of treatment.
The vibratory sensation threshold (VST) was measured with a vibrometer to assess the progression of neuropathy in patients with end-stage renal disease. Normal patients and patients receiving chronic hemodialysis were studied. We found that the longer the patients were dialyzed, the lower their VST (P less than 0.01). Regression equations were established to predict threshold values versus age of both groups, and VST versus months on dialysis in the patient population. Vibrometry was an important addition to the assessment of peripheral neuropathy in our dialysis patients. It offers low cost, little patient preparation, and requires little professional time for examination and interpretation.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.