Search PubMed⌕ Search

Biomedical subjects

C Ponticelli

Publications and source records attributed to C Ponticelli.

At least 289 records · Page 16Linked to original sources
PubMed1976

Lipid patterns in haemodialysed and transplanted patients.

The plasma lipid pattern was investigated in 103 dialysis patients and 66 renal transplant patients. Only 32 percent of dialysed patients and 30 percent of transplanted patients had a normal lipid pattern. In other patients the most frequent disorder with hypertriglyceridaemia, and less frequently combined or isolated hypercholesterolaemia. Since these lipid abnormalities are known to predispose to an accelerated atherosclerosis, a dietetic therapeutic approach was tried. Fifteen transplanted patients with severe hypertriglyceridaemia were submitted to a hypocaloric (1700 kcal) and low carbohydrate (130 g) diet. During dieting the plasma lipid pattern was normalised and maintained in a normal range for the period of observation (3-12 months).

Adolescent↗
PubMed1975

A modified rosette inhibition test in renal allotransplantation.

The rosette inhibition test, with a modification of the technique which enables highly accurate marking of T lymphocytes, has been employed in the followup of 55 renal transplant patients. The minimal inhibitory concentration of antilymphocyte globulin (that is, that concentration of antilymphocyte globulin causing 25% inhibition of rosette formation) was higher than 1:16,000 in 63 (97%) of 65 separate determinations made during acute rejection episodes, and lower than 1:16,000 in 377 (92%) of 410 determinations after which no clinical evidence of rejection developed. The results presented in this paper indicate that this modified test is a useful tool either to predict the occurrence of or to confirm the diagnosis of rejection.

Abscess↗
PubMed1975

A modified rosette inhibition test in the early diagnosis of renal allograft rejection.

The rosette inhibition test has been employed in the follow-up of 30 renal transplant patients using a technique which enables highly accurate marking of T-lymphocytes. The minimal inhibitory concentration (MIC) of anti-lymphocyte globulin (ALG) - that is, that concentration of ALG causing 25% inhibition of rosette formation-was higher than 1/16,000 in 32 (97%) out of 33 separate determinations made two to six days befor rejection became clinically evident, and lower than 1/16,000 in 323 (92%) out of 351 determinations after which no clinical evidence of rejection developed. The results presented in this paper indicate that this modified test is a useful tool either to predict the occurrence of or to confirm the diagnosis of rejection.

Graft Rejection↗
PubMed1975

Reversible acute anuric lupus nephritis.

Six cases of acute anuric lupus nephritis are described; renal biopsy showed intracapillary proliferation, epithelial crescents in some glomeruli, wire loops, and intracapillary thrombi. In two patients there were thrombotic occlusions and fibrinoid necrosis of arterioles. The patients were treated by heparin at anticoagulant doses, corticosteroids and dialysis (four). All patients showed improvement of renal function. One died following a gastric haemorrhage - the others were alive and well 64, 61, 40, 40 and 22 months from the onset of renal failure. One patient had a second episode of acute renal failure after 39 months and improved after resumption of heparin and high doses of steroids. It is suggested that heparin and high doses of corticosteroids may be a successful treatment in acute anuric lupus nephritis.

Acute Disease↗
PubMed1975

Urinary acidification in renal allografts.

Urinary acid excretion was measured in 35 human renal allograft recipients during the first few days after the onset of diuresis and two months after transplantation. In 16 out of 17 rejection episodes an early significant decrease of renal total net H+ excretion was observed. This urinary acidification impairment preceded the serum creatinine increase. Only few patients showed variations in blood pH and C1-. The acidification defect may be due to the ischaemic changes of rejection. Early impairment of urinary acidification supports a clinical diagnosis of rejection.

Bicarbonates↗
PubMed1974

Acute renal failure in systemic lupus erythematosus.

Acute anuric renal failure complicating systemic lupus erythematosus does not usually respond to treatment with corticosteroids and immunosuppressive agents. We describe four cases treated by dialysis, corticosteroids, and heparin in anticoagulant doses in which there was remarkable improvement in renal function after prolonged anuria. One patient died later from a gastric haemorrhage. The other three were alive and well 55, 54, and 30 months from the onset of anuria. In two cases a second renal biopsy showed a striking improvement in the lesions. Large doses of corticosteroid and heparin may be the best treatment in acute anuric lupus nephritis.

Acute Kidney Injury↗