Biomedical subjects

C Picado

Publications and source records attributed to C Picado.

At least 127 records · Page 7Linked to original sources

PubMed1988

Arnold-Chiari malformation and paralysis of the diaphragm.

A woman aged 17 years presented with symptoms of somnolence. A bilateral diaphragmatic paralysis and an Arnold-Chiari malformation were diagnosed. Lung function tests revealed a marked restrictive defect and a blunted ventilatory response to hypercapnia and hypoxia. A sleep study also showed central apneas, an irregular pattern of breathing and marked hypoventilation.

Adolescent↗

PubMed1988

Muscle atrophy in severe exacerbation of asthma requiring mechanical ventilation.

An unusual case of acute muscular atrophy in a patient with a severe exacerbation of asthma requiring mechanical ventilation is reported. High doses of pancuronium bromide and 6-methylprednisolone were administered. It is suggested that the conditions of mechanical ventilation increase in some way the potential of corticosteroids to cause myopathy. The possible implication of myorelaxant drugs in the development of this complication is also suggested.

Albuterol↗

PubMed1988

Ability of asthmatics with and without respiratory arrest to detect added resistive loads.

Asthmatics who sometimes experience respiratory arrest during an exacerbation are a particular concern. To date no adequate explanation exists for this phenomenon. Impaired perception of resistive loads is considered a factor in the development of hypercapnic respiratory failure, especially during exacerbation in patients with chronic obstructive pulmonary disease. We analyzed the perception of resistive loads in 10 asthmatics who had suffered two or more respiratory arrests during an acute exacerbation. A group of eight asthmatics (same mean age and basal bronchial obstruction) who had never developed respiratory arrest or acidosis during their exacerbations was also studied. No statistically significant differences were found between the two groups in the perception of resistive loads. This negative result seems to exclude a deficiency in the ability to detect resistive loads as a cause of respiratory arrest in asthmatic patients.

Adult↗

PubMed1988

Effect of three different bronchodilators during an exacerbation of chronic obstructive pulmonary disease.

This study evaluates the effect of three different bronchodilators (beta 2-adrenergic, anticholinergic and methylxanthine) alone and in randomized sequence, during an exacerbation in thirteen patients with chronic obstructive pulmonary disease. Dose-response curves were obtained for inhaled salbutamol and inhaled ipratropium bromide. The bronchodilator effect of a perfusion of aminophylline was also assessed. When a plateau of bronchodilatation was achieved with one agent, one dose of a second bronchodilator was administered to see whether additional bronchodilation could be achieved. The increments in FEV1 and FVC were similar with the three agents. The addition of a second bronchodilator did not result in significant increments in most of the patients. In at least half of the patients the doses of salbutamol and ipratropium that produced the maximal bronchodilatation were twice that currently employed.

Aged↗

PubMed1988