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Biomedical subjects

C Perrin

Publications and source records attributed to C Perrin.

At least 55 records · Page 3Linked to original sources
PubMed1987

Treatment of caffeine intoxication by exchange transfusion in a newborn.

The symptoms of acute poisoning after accidental administration of ten times the usually prescribed dosage of caffeine in a premature infant included the following neurological signs: incessant tremors, hypertonia, continuous opisthotonos posture, whining and crying and digestive disturbances. The very high serum caffeine levels, 160 mg/l, determined 66 hours after the first administration was confirmed by the very high cerebrospinal fluid caffeine concentration 115 mg/l. Two exchange transfusions performed at an interval of 16 hours produced a large decrease in serum caffeine levels of approximately 40 mg/l each time, and a similar decrease in the cerebrospinal fluid concentration. The clinical status of the infant improved very rapidly and the child's psychomotor development was normal at 3 months of age.

Acute Disease↗
PubMed1987

[Complete neurological recovery after major neonatal acidosis].

After a severe fetal asphyxia, an hypotrophic (PN: 2,500 g) full-term newborn had a very poor Apgar score (1 after 1 min) and intensive resuscitation was necessary. The first arterial blood gas analysis at 1 h of life showed a profound metabolic acidosis (pH: 6.7; base defect: -30) and refractory hypoxemia (PaO2: 11 mmHg; FiO2 = 1). In a first time, the outcome was favourable after the correction of acidosis and treatment with tolazoline of a persistent fetal circulation. The depressed cerebral function symptoms disappeared within a few days; a grade I subependymal haemorrhage disappeared also rapidly. At 22 months of age, the infant had no significant developmental abnormality.

Acidosis↗
PubMed1987

[Acute hydrocephalus drained in emergency. Consequence of cerebellar infarction in Haemophilus meningitis].

A 2 year-old child admitted for Haemophilus meningitis was immediately treated by adequate antibiotic treatment. Three days later multiple hypertonic strokes and periodic respiration occurred; a resuscitation was necessary. CAT scan showed an acute hydrocephalus with non visible 4th ventricle and low-density areas in both cerebellar hemispheres allowing the diagnosis of cerebellar infarction. External drainage of CSF was rapidly performed and maintained for 11 days with success. The child was secondarily discharged with temporary cortical blindness and persistent moderate static cerebellar signs. The etiology of the cerebellar infarction was likely to be an arterial thrombosis in the vertebro-basilar area, probably secondary to cerebral arteritis related to Haemophilus.

Acute Disease↗
PubMed1986

[Esophageal pH measurements in newborn infants. Value and indications].

Esophageal pH monitoring is now the most reliable test in the diagnosis of gastroesophageal reflux (GER) in infants and children. A 18-24 hr esophageal pH monitoring is undertaken in 26 newborns to validate this test for this age group where GER is frequent with fair correlation of clinical presentation. In 19 infants with suspicion of GER, this test give a positive diagnosis in 12 of them. Seven out of these 12 infants have another investigations (barium- esophagram - scintigraphy - esophagoscopy) with only a positive diagnosis of GER in 4 cases. Esophageal pH monitoring in 7 control infants show that the percent of monitoring time with pH below 4.0 is one of the best discriminative values (upper limit: 4.2%) for the diagnosis of GER. Unusual symptoms of GER in the neonatal period as apneic spells, dyspnea, cyanosis or neurological signs are indications for esophageal pH monitoring.

Barium Sulfate↗
PubMed1985

[Value of echography in the diagnosis of hematomas of the digestive tract wall in rheumatoid purpura].

Three cases of Henoch-Schönlein purpura with intramural hematoma of the duodenum, jejunum or colon are reported. In the first 2 cases, there was complete agreement between the X-ray and ultrasonographic data: multiple thumb print defects and irregular narrowing of the digestive lumen, and thickening of the intestinal wall, respectively. Ultrasonography was the only investigation performed in the third case. Finally, in 2 of 3 cases an exudative enteropathy of unclear mechanism was discovered.

Child↗