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Biomedical subjects

C P Bates

Publications and source records attributed to C P Bates.

At least 19 recordsLinked to original sources

A urodynamic study of laser ablation of the prostate and a comparison of techniques.

OBJECTIVE: To evaluate the effect of laser ablation of the prostate on symptomatic and urodynamic parameters and to compare laser delivery systems. PATIENTS AND METHODS: The study comprised 81 patients of whom 79 were waiting for transurethral resection of the prostate (TURP) and two who presented in acute urinary retention. The 79 patients (median age 65 years, range 45-82) underwent pre-operative urodynamics and all patients completed American Urological Association (AUA) symptom score questionnaires before surgery. Visually-guided laser ablation of the prostate (VLAP) was performed and the urodynamics and symptom scores were repeated 3 months later. RESULTS: The improvements in symptom scores and flow rates were statistically significant and comparable with other published data. There were also significant improvements in voiding pressure. There were no significant differences between the various laser fibres used. There were few complications. CONCLUSION: The effectiveness of VLAP in improving symptoms and flow rates in patients with benign prostatic hyperplasia (BPH) is confirmed. The procedure also reduced voiding pressure, confirming the relief of bladder outflow tract obstruction. VLAP is confirmed as a safe and effective treatment for BPH. Continued follow-up is needed to determine the long-term effects.

Aged

Ureteric stricture formation following ureteric instrumentation in patients with a nephrostomy drain in place.

OBJECTIVE: To determine what effect the presence of a nephrostomy, left on free drainage, might have on the rate of occurrence of ureteric strictures after ureteric instrumentation. PATIENTS AND METHODS: Eighteen patients were identified in this unit who had had ureteric instrumentation while a nephrostomy was in place. RESULTS: Eight of 11 patients in whom the nephrostomy was left open developed ureteric strictures. None of seven patients in whom the lumen was maintained by stenting and/or clamping of the nephrostomy developed strictures. The strictures needed dilatation and stenting in seven patients and the ureter had to be reimplanted in the other. CONCLUSION: In patients in whom a nephrostomy is in place, the opening should be occluded after ureteric instrumentation or a stent should be inserted if it is to be left on free drainage.

Adult

Clam enterocystoplasty in general urological practice.

A series of 45 patients (31 female) underwent clam enterocystoplasty for urgency and incontinence. The majority had detrusor instability. Prolonged conservative treatment had failed in all cases. Improvement occurred in 71% and those younger than 30 years had better overall results; 29% remained incontinent, with 9% requiring a urinary diversion. Many patients did not achieve maximum benefit until 9 months post-operatively. Surgery had no statistically significant effect on any urodynamic parameter and post-operative complications were common. The operation was performed in either the coronal (19) or the sagittal plane (26); this did not influence results. In general, surgery was found to be technically simpler in the sagittal group and it is recommended that this becomes the standard procedure. We feel that this operation involves major surgery and should only be offered with reluctance.

Adult

Carcinoma of the prostate of ductal origin.

Thirty-nine patients with ductal prostatic carcinoma have been reviewed. Their mode of presentation, initial stage, plasma phosphatase levels and response to hormone therapy were found to be similar to those in a group of 124 patients with the common acinar prostatic cancer. Histochemical examination demonstrated prostate-specific antigen in all ductal carcinomas.

Aged

Nesbit's operation for Peyronie's disease.

Nineteen patients with Peyronie's disease were treated by a modification of Nesbit's operation. The deformity was completely corrected in 18 patients. Potency was restored to 4 of the 6 impotent patients and satisfactory coitus became possible for 15 patients, whereas it had been possible for only 3 before operation.

Adult

An in vitro physiological study of normal and unstable human detrusor muscle.

A systematic in vitro physiological study of isolated human detrusor muscle strips is reported. Detrusor strips were obtained at operation. Pre-operative urodynamic studies enabled specimens to be classified as normal or unstable. Comparisons were made between responses of normal and unstable detrusor strips. The results provide evidence of a previously undescribed feedback-loop operating via pre-synaptic alpha-adrenoceptors which controls detrusor contractility. Further evidence is provided suggesting that an imbalance in this system is present in unstable detrusor muscle.

Acetylcholine

A comparative study of symptoms and objective urodynamic findings in 214 incontinent women.

Videocystourethrography was used to investigate 214 incontinent women. Their urinary symptoms were assessed in relation to urodynamic findings. Nocturia, nocturnal enuresis and urge incontinence were the most reliable symptoms distinguishing those patients with detrusor instability. Frequency of micturition and urgency were less reliable in this respect, and it was felt that these symptoms were not indications for videocystourethrography.

Adolescent

The nature of the abnormality in bladder neck obstruction.

There is no dispute that there exists, in men, a condition of obstruction at the bladder neck in the absence of fibrous stricture or prostatic enlargement. The condition was clearly described by Guthrie (1836) and Young (1913) reported the results ff punch resection operation in over 50 cases. The large measure of success now achieved following resection of the bladder neck in these patients has perhaps been allowed to mask our ignorance of the nature of the abnormality and thus discourage studies of its cause. It is perhaps most often thought to result from fibrosis but a number of studies--for example Baadenoch (1949)--have shown no associated increase in fibrous tissue. Certainly the condition is in no way similar to the hard fibrous stricture seen more often in the distal urethra, or at the bladder neck as an occasional complication of prostatectomy. Our study shows that the obstruction if functional in nature and is due to the tightening of the bladder neck as the detrusor contracts.

Adolescent