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Biomedical subjects

C Ori

Publications and source records attributed to C Ori.

At least 37 records · Page 2Linked to original sources
PubMed1992

Cerebral blood flow changes induced by electrical stimulation of the Gasserian ganglion after experimentally induced subarachnoid haemorrhage in pigs.

The effect of trigeminal electrical stimulation on cerebral blood flow has been studied in conditions of normal or reduced cerebral blood flow (CBF). Autologous blood was injected into the subarachnoid space of ten Pittmann-Moore pigs to induce subarachnoid haemorrhage (SAH) accompanied by cerebral blood flow (CBF) reduction. One week later, in six of ten animals, a considerable decrease of CBF was noted as evaluated by means of a recording-system monitoring over the right parieto-temporal calvarium the washout of 133Xenon injected into the internal carotid artery after the external carotid had been clamped. Continuous electrical stimulation of the Gasserian ganglion performed in the six animals with severely induced CBF reduction produced a remarkable cerebrovascular dilation and increase of CBF lasting over 3 h. Electrical stimulation of the Gasserian ganglion produced a similar pattern of vasodilation in six pigs in which no blood was injected and no reduction of CBF was evident. The mechanisms and the anatomical pathways which underlie these results are discussed.

Animals↗
PubMed1992

[Elderly patients in psychosomatic psychotherapeutic institutions].

With the aid of a comparative study of the data collected in the Berlin Psychotherapy Study and the outpatient clinic of the Psychosomatic Clinic (University of Heidelberg), the allocation and utilization modalities of elderly patients with regard to psychosomatic-psychotherapeutic institutions is investigated. One important result seems to be the high rate of psychodynamically understandable triggering situations (as a measurement of psychological comprehension of the symptoms) and the consequent therapy recommendations (as a measurement of treatability) even for elderly patients. A case study will demonstrate that the danger may arise to subsume new somatic symptoms in the elderly under the aspect "multimorbidity" and thus withhold recommended psychotherapeutic treatment.

Adaptation, Psychological↗
PubMed1992

[Epileptogenic complications of neurosurgical interventions].

Epileptogenic complications after supratentorial intracranial surgery are, strictly defined, the events which promote a further complication, i.e. seizures in any form, partial, simple or complex, or generalized. The most common epileptogenic complications are, therefore, electrolyte imbalance, hypoxia, hypoglycemia, hypocapnia, and intracerebral or extradural hematoma. However, also inadequate anticonvulsant prophylaxis and use of convulsant drugs can yield to the onset of post-operative seizures. Anesthetic drugs have been each time defined pro or anti-convulsant: however, data from the literature show that it is not possible to certainly define the role of general anesthetics in the genesis of post-operative seizures.

Anesthetics↗
PubMed1990

Central action of psychomotor stimulants on glucose utilization in extrapyramidal motor areas of the rat brain.

Psychomotor stimulants increase regional cerebral metabolic rates for glucose (rCMRglc). To determine if effects in motor areas reflect limb movements, we measured rCMRglc in gallamine-paralyzed rats given cocaine, methylenedioxymethamphetamine, amphetamine, or phencyclidine. Results resembled findings in partially immobilized rats. One difference was lack of cocaine-induced stimulation in the caudate-putamen despite an increase in partially immobilized rats. Therefore, stimulant-induced rCMRglc stimulation in most motor areas is a primary CNS effect.

3,4-Methylenedioxyamphetamine↗
PubMed1990

Basilar arterio-venous pseudoparallelism due to persistence of embryonal venous pattern.

A vascular malformation, consisting of a venous vessel bridgeing the right inferior petrosal sinus and the anterior spinal veins, was found in the posterior fossa. The vessel presented a ring-like course around the right trigeminal root, and it was parallel and dorsal to the basilar artery. The malformation was associated with cutaneous and hepatic angiomas and peri-osteal lipomas. It had been clinically silent for 52 years, when it thrombosed causing death. The authors think that, within a general mesenchymopatic state, this is a result of the persistence of an embryonal cerebral venous pattern.

Autopsy↗
PubMed1990

The effects of propofol anesthesia on local cerebral glucose utilization in the rat.

The autoradiographic 14C-2-deoxy-D-glucose method was used to determine local cerebral glucose utilization (LCGU) during propofol anesthesia and recovery in 52 regions of the rat brain. Control rats intravenously received 5 ml.kg-1.h-1 of the egg-oil-glycerol emulsion that constitutes the vehicle for propofol. Anesthetized animals received an iv bolus of propofol (20 mg/kg) followed by continuous infusion of the anesthetic at 12.5, 25, or 50 mg.kg-1.h-1 for 1 h prior to injection of 14C-2-deoxy-D-glucose and for the following 45 min. In addition, a fifth group of animals were studied immediately after awakening from a 20 mg/kg bolus of propofol as indicated by the first reappearance of head lift. All rats were spontaneously breathing room air throughout the experimental procedure. The general pattern of the cerebral metabolic response to propofol anesthesia was a dose-related, widespread depression of LCGU. At the three infusion rates of propofol tested, overall mean LCGU was reduced by 33%, 49%, and 55%, respectively, and significant decreases were observed in 60%, 85%, and 90% of the regions assayed. These effects were rapidly reversible, since in the recovery group, LCGU returned to near control values in the majority of the brain areas. Although all of the anatomofunctional systems (sensorimotor, extrapyramidal, limbic, and reticular) were involved, forebrain structures showed a greater sensitivity to the depressant action of propofol than did hindbrain regions.(ABSTRACT TRUNCATED AT 250 WORDS)

Anesthesia, Intravenous↗
PubMed1989

Diencephalic syndrome following cervical spinal cord trauma.

The authors discuss about five cases of diabetes insipidus observed in patients affected by traumatic cervical spine fractures and/or dislocations, without either evident lesions of the cerebral structures at CT scan examination, or important craniocerebral trauma. In all patients polyuria and hyperthermia arose some days after the traumatic accident and regressed spontaneously or after exogeneous vasopressin administration. Vasopressin urinary levels confirmed the presence of a true diabetes insipidus, the origin of which is in largely obscure. A central medullary vasopressin mediated pathway, demonstrated only in experimental animals, may be responsible for such a finding.

Adolescent↗
PubMed1989

Effects of nitrous oxide and halothane on mu and kappa opioid receptors in guinea-pig brain.

The effects of two general anesthetics, nitrous oxide and halothane, and oxygen on mu and kappa opioid receptor subtypes from guinea-pig brain were investigated. mu receptor binding was defined using [3H]dihydromorphine as the ligand. Nitrous oxide (100%) and halothane (2%) decreased the [3H]dihydromorphine binding affinity (Kdair = 0.87 nM, KdN2O = 1.45 nM, Kdhalothane = 2.30 nM) without affecting the density of binding sites. A decrease in the [3H]dihydromorphine binding affinity without influence on the density of binding sites was also observed in the presence of 100% oxygen (KdO2 = 1.40 nM). kappa receptor binding was defined using [3H](-)ethylketocyclazocine as the ligand, in the presence of 100 nM D-ala2-D-leu5-enkephalin and 30 nM morphine. While 100% nitrous oxide caused a slight decrease in [3H](-)ethylketocyclazocine binding affinity (Kdair = 0.24 nM, KdN2O = 0.31 nM) and a substantial decrease in the density of binding sites (Bmaxair = 115 fmol/mg protein, BmaxN2O = 84 fmol/mg protein), halothane dramatically affected both the affinity (Kdhalothane = 0.70 nM) and density (Bmaxhalothane = 38 fmol/mg protein). Oxygen (100%) reduced [3H]dihydromorphine binding affinity. Differential effects of two anesthetics on the same receptor or distinct actions of the same anesthetic on different receptors could indicate the presence of specific targets for anesthetics at the membrane level. Conversely, effects of volatile anesthetics on opioid receptors could reflect a non-specific perturbation of the lipidic and proteinaceous components of the membranes.

Analgesics, Opioid↗
PubMed1989

[Tracheal cannulation technics in cervical vertebral and spinal cord injuries. A comparative study].

Cervical vertebral dislocations and fractures require the complete immobility of the neck until an intervention of stabilization of the spinal cord, by surgery or external means, is performed. Endotracheal intubation, which might represent a harmful operation, can become difficult when the stabilization of the spinal cord has been obtained by external means. Moreover, the anatomical features of the patients can well cause further difficulties in intubation. Three different methods for endotracheal intubation have been assessed in cervical cord injured patients (fracture and/or dislocation from C2 to C6 level) by evaluating invasivity, mean intubation time, and success rate. Each method presents advantages with regard to the grading of visualization of the larynx, but also limitations due to the time required to perform the intubation and the appearance of complications. It seems therefore useful to continue the search for the ideal method for tracheal intubation, which should be absolutely atraumatic, fast, and completely successful.

Cervical Vertebrae↗