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Biomedical subjects

C Oh

Publications and source records attributed to C Oh.

At least 55 records · Page 3Linked to original sources
PubMed1986

Pituitary-dependent and -independent secretion of CS caused by bacterial endotoxin in rats.

Injection of bacterial endotoxin [lipopolysaccharide (LPS)] or immobilization stress increased serum levels of ACTH with a concomitant increase in the levels or corticosterone (CS) of rats. LPS also caused a significant increase in the serum CS levels of hypophysectomized rats. In contrast, immobilization stress-induced CS release was abolished completely in these rats. Injection of histamine, a possible mediator of LPS-induced CS secretion, provoked a significant increase in the serum CS levels of hypophysectomized rats. Neither histamine nor LPS had any appreciable effect on production or release of CS by cultured adrenal cells. These results suggest that LPS-induced CS secretion is largely dependent on hypophysial ACTH release but it also depends, in part, on an extrapituitary mechanism and that the LPS-induced pituitary-independent secretion of CS is mediated by histamine produced in the peripheral tissues. On the other hand, stress-provoked CS secretion is absolutely dependent on the pituitary-adrenocortical system.

Adrenal Glands↗
PubMed1983

Management of high recurrent anal fistula.

Fifteen patients who had recurrent high anal fistulas were treated at the Mount Sinai Medical Center from 1975 to 1981--12 men and 3 women, all of whom had already undergone fistulectomies from one to four times elsewhere. The fistulas were managed with coring of the tract (complete extirpation), including side tracts, if present, and primary closure of the internal opening with advancement rectal mucosal flap distal to the original fistulous opening. Thirteen of 15 patients had satisfactory results; two patients required reoperation for recurrences. The advantages of the advancement flap technique over the staging division technique are discussed. We have found our procedure to be very useful for high anal fistulas, particularly for patients with recurrent high anal fistulas in whom there is already some degree of sphincter damage and scar formation.

Adult↗
PubMed1982

Problems of cryohemorrhoidectomy.

One thousand cryohemorrhoidectomies were performed in the past 7 years (1973-1979). Ninety percent of the patients were satisfied with the technique; approximately one-third of the patients experienced severe to moderate pain and 11% had recurrences or related problems. The majority of patients with postoperative pain were in the younger age group and two-thirds of the recurrences occurred in males. Our data suggest that there is a close relationship between complications and anal pressure. These facts lead us to believe that patients with high anal pressure are prone to recurrence and postoperative pain--for these patients one must not only remove the hemorrhoidal mass but also lower the anal pressure by internal sphincterotomy. On the basis of these assumptions, we have operated on 200 patients using internal sphincterotomy along with hemorrhoidectomy; early results have been promising. We recommend cryohemorrhoidectomy limited to those who have prolapsing internal hemorrhoids without significant constipation or external engorgement which is indicative of high anal pressure.

Adult↗
PubMed1982

Necrotizing fasciitis of perineum.

Twenty-eight patients with necrotizing fasciitis of the perineum were treated at the Mount Sinai Medical Center from 1971 to 1979. Ten of the 28 died of the disease, for a mortality rate of 36%. The mortality rate was even higher when the lesion was located in the perianal area and associated with diabetes mellitus and delayed surgical intervention. Necrotizing fasciitis is a rare disease that involves both superficial and deep fascia. It begins with fascial necrosis at onset and rapidly progresses to surrounding fascial planes, eventually involving overlying skin and underlying muscle. Evidence proves that it is not the result of abscess, but primarily originates from fascia and is devoid of frank pus in the well-formed pyogenic abscess cavity. If one observes dark brown necrotic turbid fluid and fails to see frank pus, the disease should be treated as necrotizing fasciitis by complete surgical removal of all necrotic tissue until the normal plane is reached.

Adolescent↗
PubMed1979

Necrotizing fasciitis of genitalia.

A review of 12 patients with necrotizing fasciitis of the genitalia is presented. All patients had rapidly progressing cellulitis and necrosis of the fascia caused by a combination of various organisms, most frequently by Escherichia coli. Beta streptococcus, which is generally thought to be the causative organism in these cases, was present in only 4 patients. Management consisted of extensive surgical debridement, urinary and/or fecal diversion, antibiotics, and necessary reconstructive procedures.

Adult↗
PubMed1978

A modified technique for lateral internal sphincterotomy.

A technique for lateral subcutaneous internal sphincterotomy has been used in 300 patients. In 200, the blind method was used, and in 100, the open technique was used. Although the number of patients and the follow-up period were not matched, the early results were somewhat better with the group of patients who underwent the open technique than with those who underwent the blind procedure, particularly in regard to postoperative bleeding. We recommend this technique both to minimize bleeding and to afford the surgeon more technical control.

Anus Diseases↗
PubMed1977

Leiomyosarcoma of the anus: report of a case.

We have presented an unusual case of leiomyosarcoma of the anus. On reviewing the literature, we did not find a similar case. This tumor metastasizes mainly to distant organs through the bloodstream. We treated the tumor by wide excision, followed by chemo-immunotherapy, hoping to sterilize possible microemboli. Since this type of lesion is very aggressive, we strongly suggest that any mass in the perianal region be excised and biopsied.

Adult↗
PubMed1975

Factitial panniculitis and necrotizing fasciitis in juvenile diabetes.

A fifteen-year-old diabetic girl developed multiple inflammatory areas on the extremities and abdominal wall at the site of insulin injection. The bizarre clinical manifestations led to great difficulties in determining both its etiology and its treatment. However, three months after her initial hospitalization, we found that the lesions were probably secondary to self-injection with a chemical agent rather than a result of insulin allergy. If idiopathic recurrent dermal infection is observed, then factitial origin should be suspected.

Abdomen↗
PubMedDate not supplied

Anoplasty for anal stricture.

Twelve patients with anatomic anal stricture were treated with C-anoplasty in the past six years. Anal stricture was caused by previous hemorrhoidectomy in ten, fistulectomy in one, and fissurectomy in one. All patients had had conservative treatment from four to 22 years but failed to respond. Eleven patients obtained satisfactory results from C-anoplasty; one required three anal dilatations postoperatively because of restricture. C-anoplasty is advantageous because it extends the pedicle without compromising vascular supplies; suture-line tension can be controlled by extending the incision; and the size of the graft is easily adjustable to anal size.

Adult↗
PubMedDate not supplied

Giant-cell tumor of the sacrum.

We have presented a case of a patient with sacral giant-cell tumor and reviewed the literature. This is a rare disease originating from the mesenchyme of bone marrow which grows out through the cortex. It is essentially benign but behaves like a malignant tumor in view of frequent recurrences and a high incidence of malignant transformation. Cure can be achieved only by complete extirpation of tumor along with surrounding soft tissue.

Colostomy↗