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Biomedical subjects

C O Callender

Publications and source records attributed to C O Callender.

At least 73 records · Page 4Linked to original sources
PubMed1977

The story of the Howard University Transplant Center: (a project of the people).

It took almost two years for Howard University Hospital to receive certification as a kidney transplant hospital under the federal government's end-stage renal disease program, although Howard had a transplant program that was comparable to many in the country.By the time the Department of Health, Education, and Welfare approved Howard's program, many successful transplants had already been carried out there, largely on indigent patients who probably could not have received transplants elsewhere or on patients whose chances of survival, because of other complications, were so risky that other hospitals had turned them down. At first the high cost of these operations had to be absorbed by the University since the government reimbursed only those hospitals which had an approved transplant program.Howard has now received reimbursement (payments of more than $500,000) for its transplants because its certification was granted retroactive to July 1, 1973, when the federal program was started. So the Transplant Center is now enabled, and committed, to provide the best possible transplant care to the Washington, D.C. community which, incidentally, has one of the highest incidences of kidney failure in the country.

Certification↗
PubMed1976

Spontaneous renal allograft rupture without rejection: a case report.

A case of spontaneous renal allograft rupture is described. Typically, this infrequent transplant complication occurred in the early post-transplant period in an oliguric setting with progressive pain, tenderness and swelling at the transplant site associated with hypotension and a decreasing hematocrit. Prompt surgical exploration and repair of the defect in the convex border of the renal allograft controlled hemorrhage and resulted in graft survival, and a normal blood urea nitrogen and creatinine 10 months after transplantation. There have been no rejection episodes and the renal biopsy demonstrated no evidence of rejection or acute tubular necrosis. Ice preservation for 24 hours and changes secondary thereto may have made the kidney susceptible to rupture when the position of acute flexion was assumed.

Adult↗
PubMed1975

Effect of concanavalin A and phytohemagglutinin on the modification of immunogenicity of canine kidney allografts.

Mongrel dog kidneys were allografted to unrelated nephrectomized recipients which were then treated with subimmunosuppressive doses of azathioprine (2.5 mg/kg/day). Dog kidneys treated in vitro with perfusates containing concanavalin A (Con A) or phytohemagglutinin-P (PHA) survived as long as 60 days (mean 39.8 +/- 4.3) after transplantation, whereas normal kidneys survived less than 16 days. The optimal prolongation was achieved by perfusing the kidneys with 500 ml Ringer's lactate containing 25 mg/L Con A, 25 4 degrees C. Lesser effects were achieved with higher or lower concentrations of Con A, or with perfusions carried out at 25 degrees C. Most evidence suggests that Con A and PHA bind to cell surfaces and interfere with the perception of the graft antigens by the host.

Animals↗