Biomedical subjects
Publications and source records attributed to C Newman.
Eighteen patients developed abnormally low serum glutamic oxaloacetic transaminase values during metronidazole therapy. Metronidazole absorbs at 340 nm, simulating reduced nicotinamide adenine dinucleotide, which is the final colorimetric product of the serum glutamic oxaloacetic transaminase assay.
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The supine pressor test was performed on 207 nulliparous young women between the twenty-eighth and thirty-second weeks of gestation. The supine pressor test predicted pregnancy-induced hypertension in 78 per cent of those women who subsequently developed the condition. Ninety-six per cent of the women who failed to demonstrate a rise in diastolic pressure on position change remained normotensive throughout the remainder of the pregnancy.
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Twenty patients with either missed abortions or intrauterine fetal death were induced with prostaglandin (PGE2) vaginal suppositories. The uterus is surprisingly responsive to PGE2 in cases of intrauterine death, yielding a short treatment-delivery interval. Blood coagulopathies which can develop after intrauterine death can be avoided through early diagnosis and treatment. Eighteen patients completely delivered and there were no serious complications. The remaining 2 patients required curettage. Side effects were mild in nature, consisting of occasional gastrointestinal symptoms. This method is now a standard procedure in cases of intrauterine fetal death and missed abortion at Yale-New Haven Medical Center.
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