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Biomedical subjects

C Mittermayer

Publications and source records attributed to C Mittermayer.

At least 145 records · Page 8Linked to original sources
PubMed1980

A simple and rapid method for postmortem radiographic investigation of lung fine structure.

Radiologic pathologic correlation of lung specimens requires a gas content identical to intravital conditions. Methods of air drying and formalin steam fixation are well known but time consuming. A new, rapid method is presented: the lungs are inflated with compressed air, frozen in liquid nitrogen, and cut into slices. Radiographs taken with soft tissue technique demonstrate structural details down to 200-300 mu. The excellent state of preservation also permits excellent quality of microscopic slides.

Air↗
PubMed1980

[Volume controlled fixation of the lung by formalin vapor (author's transl)].

A new method of lung fixation by formalin vapor is presented. A simple Engstrøm type respirator modified for postmortem formalin insufflation of the lung was developed. Rapid fixation requires use of hot formalin vapor which would destroy available equipment. The main advantage compared to other described methods beside the constant volume is sufficient stirring of formalin and formalin vapor. In order to prevent condensation of water within the lung parenchyma any cooling of the vapor should be avoided. If the lungs are fixed by this method the tissue will stiffen in a position between in- and exspiration. Slices of 1 cm are cut. Radiographs in soft tissue technique guarantee unusual high resolution. Positive findings are identified easily and furthermore studied by microscopy: the direct correlation between X-ray finding and microscopy becomes possible.

Adult↗
PubMed1980

[Percutaneous catheter dilatation of carotid stenoses --animal experiments (author's transl)].

Thirty-one carotid artery stenoses were produced in thirty dogs by three different techniques. Twenty-three of these could be cured by transfemoral percutaneous catheter dilatation. High grade tight stenoses may present resistance which cannot be overcome by the catheter. Histological examination of the dilated vessels showed circumscribed changes in the vessel wall, with destruction of elastic membranes. From our experience of catheter dilatation of pelvic and lower limb arteries and of renal arteries, we consider it feasible to use this technique in selected patients with carotid stenosis.

Angiography↗
PubMed1980

[Investigation of radiologic lung fine structure by freezing of inflated specimens in liquid nitrogen (author's transl)].

Radiologic pathologic correlation of lung specimens requires a gas content identical to intravital conditions. Methods of air drying and formalin steam fixation are well known but time consuming. A new, quick method is presented: The lungs are inflated with compressed air, frozen in liquid nitrogen, and cut into slices. Radiographs taken in soft tissue technique will demonstrate structural details down to 200--300 mu. The excellent state of preservation enables unusual quality of microscopic slides, as well.

Adult↗
PubMed1980

[A case report of macroglossia following tongue bite (author's transl)].

A variety of congenital or acquired diseases may cause macroglossia. We report the case study of a 25 year old patient with Down's Syndrome who developed macroglossia after injury to the tongue from a self-inflicted bite. Conservative therapy for one month through wound revision, antibiotics and antiphlogistics was only successful in controlling infection but failed to prevent the occurrence of a massive macroglossia. This latter problem could only be managed through reconstructive surgery. Histological studies of tissue taken from the tongue revealed the presence of an interstitial edema containing protein, but without evidence for mucopolysaccharides, glycogen or amyloid. A network of dilated blood and lymphatic vessels with partial stenoses caused by organized thrombosis and proliferation of endothelial cells could be observed, suggesting the presence of a congenital lymphangio-hemangioma. However, we believe that these findings were the result of the obliteration of lymphatic and blood vessels through trauma and inflammation to produce the patient's macroglossia.

Adult↗
PubMed1980

[Reversibility of shock-induced pulmonary fibrosis (author's transl)].

A case of shock-induced respiratory failure is reported and the diagnostic criteria of this condition are reviewed. As regards the anatomicopathological aspects the following factors are of prognostic importance: 1. pre-existing pulmonary disease, 2. integrity of the alveolar basal membranes, 3. proliferation of the pulmonary morphological elements, 4. development of immature collagenous and elastic fibres in the alveolar and extra-alveolar interspaces. A diagnostically reliable estimation of these factors is possible only by means of biopsy. Although this procedure carries some risks the incidence of complications is not higher than it is in respect of biopsies of other parenchymatous organs. However, it is advisable to reserve lung biopsies for those cases where all other non-invasive methods have failed to establish the diagnosis.

Adult↗
PubMed1980

[Shock-induced respiratory insufficiency (clinical aspects, pathology ultrastructure and morphometry)].

Interstitial oedema in the alveolar septa is the first morphologically recognisable change to be observed in cases of shock. It is brought about by the altered function of the membranes of the damaged epithelium and endothelium in the alveolar wall. At the same time there is an impairment of gaseous exchange, which is rendered more difficult by the exudative process in the interstitium. Pari passu with these events there is injury to the cells of both the alveolar epithelium and the alveolar capillary endothelium. Both these processes are still reversible. The point of irreversibility appears to be reached - so far as time is concerned - at the end of the 1st week, after which the injurious effects on the cell are established, since the thin alveolar wall, necessary for the exchange of gases, becomes overgrown with bulky alveocytes (Type II) and the fibroblasts in the alveolar interstitium crowd the capillaries away from the surface of the alveolus. In most of the advanced cases of shock this process of thickening of the alveolar wall exceeds the critical value, and respiratory exchange is so impaired that satisfactory functioning of the lungs is no longer possible.

Humans↗
PubMed1980

[Histological evaluation of pre-operative radiation in squamous cell carcinomas of the tonsil, the base of the tongue and the hypopharynx (author's transl)].

The histological diagnostics of 13 patients with epithelisma of tonsils, tongue base and hypopharynx were examined before and after radiation with 2000 cGy telecobalt 60 with a planimetric method. The quantitative results related on mean percentage of surface of five different tissues showed the following variations: 1. an increasing of dead tumor tissue from 0.5-27.5% 2. an decreasing of still vital tumor tissue from 50.7-9.7%. 3. an increasing of fibrous tissue from 3.6-17%. 4. an increasing of granulation tissue from 0.3-3.8%. 5. a decreasing of vascular tissue from 2-0.6%. - As shown by these results, this kind of radiation may satisfy the most important requirements of a pre-operative radiotherapy. Affirmations about long time results of this kind of therapy may not yet be published with the present material.

Carcinoma, Squamous Cell↗
PubMed1979

[Threedimensional reconstruction of odontogenic cysts and their relationship to teeth and bone (author's transl)].

This study reports on the first time three-dimensional presentation of odontogenic cysts demonstrated by means of a simple histological method. Histological sections of biopsy material having been embedded in paraffin were projected on cardboard. After the projections had been cut out, the single parts were arranged in a way to form a three-dimensional model. Radicular cysts are monolocular and exhibit a smooth surface. The individual cyst is surrounded unilaterally by epithelial cell remnants of Malassez opposite to the adhering tooth. The bone shows a reactive-inflammatory transformation. Keratocysts occur in connection with the Gorlin-Goltz-syndrome and reveal a primary multiple structure. Smaller cysts have a round and smooth appearance, whereas the larger ones show an irregular surface. Satellite cysts of various sizes which develop in the adjacent areas are connected with the primary cyst. We are therefore dealing with two different types of cysts: with monolocular cysts which show a complex network and are connected with satellite cysts on the one hand, and, on the other, with additional multiple cast systems including monolocular and multilocular cysts of various sizes. The surrounding bone shows the characteristics of compression atrophy rather than signs of an inflammation.

Adult↗
PubMed1979

Morphologic development of human shock lung.

In the initial phase of shock, edema spreads throughout the alveolar interstitium even before injury occurs in the alveolar epithelium and endothelium. The endothelium and the epithelium are damaged only subsequently, causing reduction in the average barrier thickness of the epithelium and the endothelium. A point of irreversibility is reached by the end of the first week. While early cell regeneration may be observed within the alveolar endothelium and epithelium, proliferation of fibroblasts and fibrosis of the alveolar wall occur in addition to edema which spreads within the interstitium. This widening of the gas exchange barrier may be considered as the anatomic substrate of respiratory insufficiency induced by shock. This enlargement continues up to the moment when thickening of the alveoli impedes satisfactory functioning of the lung, and, as consequence, threatens the life of the patient.

Cell Division↗
PubMed1979

[Prognostic factors in epipharyngeal tumors: a retrospective analysis of 151 patients treated at Freiburg (Breisgau) between 1948 and 1977 (author's transl)].

From 1948 through 1977, 151 patients with an epipharyngeal tumor underwent radiation therapy at our department. A retrospective analysis was made reviewing treatment results and prognostic features. The 5-year survival rate of the total group amounted to 39%, the 10-year survival to 27%. Tumor stage and histology were confirmed as the preponderant factors in prognostication. Stage T1--2 cases had a 5-year survival rate of 57%, which decreased to 46% if unilateral lymph node metastases had occurred, and down to 17% in case of bilateral metastasition to the lymph nodes. Of stage T3--4 patients, 45% survived during 5 years. Lymphoepithelial carcinoma, with a 5-year survival rate of 54%, had a better prognosis than squamous cell carcinoma (47%), transitional cell carcinoma (30%) and reticulum cell sarcoma (30%). A review of the results other authors have obtained since 1956 with combinations of surgical and irradiation methods gives evidence that the efficiency of techniques confined to local or regional treatment has reached its limits. At present, further improvement may be achieved mainly by means of systematically applied adjuvant chemotherapy complementary to the general thérapeutic concept.

Carcinoma, Squamous Cell↗
PubMed1979

[Topography and surgico-tactical principles of the mesocaval shunt].

The mesocaval shunt has special advantages. It can be applied also in patient with worse condition (Child B and C). The technically simple performance according to the original method of Drapanas is recommended provided that anatomical variants at the surgical trunk of the vena mesenterica superior are known. The anatomical situation should be investigated preoperatively by direct (umbilical vein catheter) or indirect mesentericography. The access via umbilical vein offers in addition the possibility of coronary vein embolisation in emergency patients.

Blood Vessel Prosthesis↗