Origin of erythropoietic and lymphopoietic stem cells in the avian embryo, studied in interspecific chimaeras.
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Biomedical subjects
Publications and source records attributed to C Martin.
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Cysts of the adrenal gland are very rare in the neonatal period and are always diagnosed either at surgery or at autopsy. Two patients are reported. One is an infant born at term in whom a mass in the left loin was discovered on the 3rd day of life. At surgery a suprarenal tumour was discovered and a polycystic adrenal was removed: recovery was uneventful. Histology showed a cystic haemangioma in the adrenocortical tissue. The diagnosis made was that of a cystic haemangioma. The other patient is an infant born at 38 weeks gestation who became jaundiced and developed a haemolytic streptococcal septicaemia. A mass was found in the right lumbar region on the 3rd day. The calcified egg-shell appearance, renal arteriography and an intravenous pyelogram demonstrated the cystic appearance of the adrenal. The cystic mass and the adrenal gland were removed and the patient recovered. Histological examination suggested that a pseudocyst had arisen secondary to a haemorrhagic infarct caused by a septic embolus. Adrenal cysts are classified as true cysts and pseudocysts (which must be distinguished from unilateral haematomas). The histological appearances are reviewed. These patients may be added to the 11 neonatal case reports in the literature (9 haemorrhagic pseudocysts, only 2 true cysts). To our knowledge cystic haemangioma has not previously been reported.
Since November 1974, 44 patients with acute myeloid leukemia, in first remission were randomized between chemotherapy alone and chemotherapy plus BCG. There were 8 relapses and 7 deaths with chemotherapy, 7 relapses and 3 deaths with chemotherapy plus BCG. The survival of both groups is not, at the time, significantly different.
The hypersensitivity reaction in Nicotiana tabacum var. Xanthi n.c. infected with Tobacco mosaic virus (T.M.V.) leads to the production of aromatic amides (ferulylputrescine, diferulylputrescine, p-coumarylputrescine and di-p-coumarylputrescine) inthe cells around the necroses. Similar compounds are formed in Xanthi plants after floral induction. p-coumarylputrescine, di-p-coumarylputrescine and caffeylputrescine strongly inhibit T.M.V. multiplication.
In the chick embryo the nephrogenic blastema cells are determined before contact with the natural inductor (Wolffian duct or ureter) is established. In response to heterogeneous inductors, such as spinal cord or embryonic endoderm, the blastema cells differentiate into complete secretory tubules as shown by immunohistology.
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Incorporation of tritiated [3H]thymidine by Chlamydia psittaci 6BC was achieved by growing the parasites in chick embryo yolk sac explants which were exposed to exogenous labeled thymidine. These labeled, purified chlamydiae were next observed by autoradiography within mouse peritoneal macrophages. The number of silver grains remained constant in the cytoplasm of macrophages throughout the developmental cycle of the parasite. The proliferation of labeled chlamydiae in macrophages was confirmed by Giemsa staining and immunofluorescence. Chlamydiae have never been successfully labeled with thymidine in earlier studies when assayed in cultured mammalian fibroblasts. It is suggested that a critical factor in the successful incorporation thymidine in chlamydiae may be the host-parasite system used.
Serum level of alpha-1-antitrypsin is significantly reduced in newborns with idiopathic respiratory distress when compared to matched controls. This decrease was predominantly due to the group of infants who died from I.R.D., provided that alpha-1-antitrypsin determination was carried out on the first day of life. Alpha-1-antitrypsin was demonstrable by indirect immunofluorescence in hyaline membranes whereas fluorescence was negative in the alveolae of infants who had no hyaline membranes.
Monosomy 9p is reported in a boy with trigonocephaly and advanced bone age.
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