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Biomedical subjects

C Martin

Publications and source records attributed to C Martin.

At least 973 records · Page 54Linked to original sources
PubMed1986

Phase II trial of 4'-epidoxorubicin in advanced gastrointestinal tumor.

Fourteen Chinese patients with histologically proven advanced gastrointestinal tumors underwent a phase II 4'-epidoxorubicin trial. 6 out of 14 (42%) patients showed static response and the rest showed progression of disease during treatment. The treatment was fairly well tolerated with a mild to moderate degree of nausea, vomiting, alopecia and hematological toxicity.

Adult↗
PubMed1986

The axillary vein: an alternative approach for percutaneous pulmonary artery catheterization.

The axillary vein route was investigated prospectively for percutaneous pulmonary artery catheterization in 79 patients who underwent 83 attempts. Forty nine of these patients were tracheostomized and under mechanical ventilation and eight had hemostasis disorders. Successful catheterization was achieved 74 times in the 79 patients. Pulmonary artery was reached within 6 +/- 2.1 min after the catheter was set in place in the axillary vein. Less than 1 min was needed in 53 cases. Puncture of the axillary artery was noted in 11 patients without complication. No other significant complication was noted following the punctures. Mean duration of catheterizations was 3.6 +/- 2 days. No septicemia was related to the catheterization procedure. One thrombosis of the axillary vein was noted. Catheterization of the pulmonary artery via the axillary vein is safe, simple and reliable and can represent an alternative method should the use of other routes be unsuccessful.

Adolescent↗
PubMed1986

[Viral serology in ear diseases of presumably neuritic origin].

A viral etiology is often advanced to explain the origin of Bell's palsy, sudden deafness and certain vertigos. Virology findings were compared in 72 patients with either chicken pox, herpes, zona or other "viral" infections, where the viral origin was not absolutely clear, and a population of healthy volunteers. Results confirmed the indefinite viral nature of these affections. However, recent studies have shown that definite viral disorders are not always associated with an increase in antibody levels, and the intervention of a virus should not be totally discounted in some of these affections, especially as several particularly demonstrative cases have provided confirmation of a virus origin, particularly the Epstein-Barr virus.

Adult↗
PubMed1986

Effects of high-calcium and/or high-sodium diet on basal and angiotensin II-stimulated blood pressure in the spontaneously hypertensive rat.

Direct conscious blood pressure (BP) was measured via indwelling femoral cannula to evaluate the effects of chronic diet supplements with Na, Ca or both, offered to 3-week-old weanling spontaneously hypertensive rats (SHR). Despite similar food intakes, body weights were reduced within 1-2 weeks on high-Ca diets. Blood pressure was unchanged by 5.5 weeks of diet treatments. However, irrespective of concomitant Na supplement, more prolonged treatment with the high-Ca diet completely abolished the further increase in BP between the 9th and 12th weeks of age, which was noted in the rats fed the normal or high-Na diets. Angiotensin-stimulated BP was attenuated by high-Ca diets regardless of diet Na, similar to basal readings. These weight and pressure effects of Ca were not reproduced by high-Na diet alone. For all four groups, BP was directly and significantly correlated with body weight, both at 9 and 12 weeks of age. These studies demonstrate the potential role of growth retardation in the antihypertensive action of oral Ca loading in young rats.

Angiotensin II↗
PubMed1986

[Clinical and pharmacokinetic study of ceftriaxone in severe infections in adults in intensive care].

Twenty patients with severe nosocomial bacterial infections hospitalized in an intensive care unit were treated by ceftriaxone alone, in a single daily IV injection of 2 g. Clinical and bacteriological results show that ceftriaxone has good activity against enterobacteria. The four patients (20%) who failed to respond had superinfection by Pseudomonas aeruginosa, a finding that suggests that ceftriaxone should be used in combination with another antibiotic for the treatment of nosocomial infections. Pharmacokinetic results in our patients show that with the dosage used peak and trough serum levels are greater than the MICs of susceptible pathogens.

Adult↗
PubMed1986

[Ankylosis of the malleus head. Etiology, therapeutic indications and results].

A review of 62 cases of blockage of head of malleus showed that apart from secondary lesions (post-traumatic, postoperative, postinfectious), primary blockades were a definite entity. The latter were either isolated or associated with stapedo-vestibular ankylosis. Isolated blockade of head of malleus provoties only direct transmission deafness, and is associated in nearly all cases with a cochlear lesion, often bilateral, at least in the primary forms. Instead of simple unblocking of the attic, the treatment preferred is an ablation of the incus, section of head of malleus and subsequent functional gestures that are described.

Adult↗
PubMed1986

[Severe subglottic edema caused by bird breeder's disease?].

A 44-year old female farmer and pigeon-breeder presented with paroxysmal attacks of dyspnoea caused by recurrent subglottic laryngeal oedema. The symptoms disappeared under corticosteroid therapy but returned after discharge from hospital. The avian origin of the disease, suggested by a strongly positive search for avian precipitins, was confirmed when the attacks ceased after antigen exclusion. A realistic inhalation challenge test performed on two occasions with pigeon's feathers and droppings as antigens resulted, within 15 minutes, in a 4-hour long attack of paroxysmal laryngeal dyspnoea. The dyspnoea was caused by subglottic laryngeal oedema visualized, 15 minutes after the inhalation, by pharyngeal and bronchial fibroscopy. Nasal manifestations have been reported in patients with hypersensitivity of the lung, but it seems that no case of subglottic oedema in pigeon-breeder's disease has yet been published.

Adult↗
PubMed1986

[Possible release of aluminum from activated charcoal filters used in home hemodialysis].

In 1984, 38 sera from home hemodialysis patients were found with a significant increase of aluminum (Al) from 67.8 +/- 44.3 to 102.0 +/- 45.9 micrograms/l (p less than 0.001) compared to 1983. The only change was an activated charcoal (AC) filter in the water treatment circuit, added downstream of the water softener. Five different home hemodialysis AC filters were tested: Microclean CA Dia Cuno, Traitement Standard des Eaux (TSE)R, Permo, C2R, Gambro. AC was shown to be the main source of Al, its content ranging from 1251 +/- 116 to 7569 +/- 969 mg/kg. Al released in 2000 l of liter rinsing water varied from 1.6 +/- 1.3 to 41.3 +/- 5.5 mg. (mean concentration: 0.8 to 20.6 micrograms/l): Gambro less than or equal to C2R less than TSE less than Permo less than Cuno (p less than 0.01). Al loading of charcoal could occur either before or during the activation process, by contaminated water, other added substances, or during packaging. In conclusion, our study suggests, first, to put AC filters upstream of Al captor to avoid Al intoxication, second, to systematically dose Al and may be other metallic substances in every manufactured AC sold for therapeutic purpose.

Aluminum↗
PubMed1986

[Recurrent purulent meningitis and deafness: Mondini's malformation].

A 5-year-old girl with severe deafness (90 dB) had two successive attacks of bacterial meningitis. A vesicular cochlea was found on polytomography, and a bilateral defect in the stapes footplate with cerebrospinal fluid leakage during surgery (Mondini dysplasia). Although rare, the eventuality of this malformation emphasises the utility of polytomography of the inner ear in children with congenital deafness.

Bacterial Infections↗