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Biomedical subjects

C Manca

Publications and source records attributed to C Manca.

124 records · Page 7Linked to original sources
PubMedDate not supplied

Non invasive evaluation of left ventricular performance in 294 diabetic patients without clinical heart disease.

The authors studied the modification of systolic time intervals (STI), pre-ejection period (PEP) and left ventricular ejection time (LVETc), before and after isometric exercise, in 294 diabetic patients without clinical evidence of cardiomyopathy and in good metabolic control compared to 132 normal subjects. The study was aimed at detecting preclinical alterations of left ventricular function. Diabetic patients considered together did not show any difference in STI in basal conditions or after isometric exercise compared to normal subjects. When diabetic patients were divided into sub-groups according to their treatment, the insulin-treated diabetics showed modification of STI after isometric exercise, which indicated an alteration of left ventricular function. Also subjects treated with oral hypoglycemic agents showed similar but less evident changes. In diabetic patients on diet only and in those with duration of diabetes of 6 months or less, STI was identical to that of normal subjects. These data do not explain the pathogenesis of myocardial involvement, although they are in accordance with studies which have laid emphasis on the alteration of compliance of the diabetic heart.

Adult↗
PubMedDate not supplied

Noninvasive evaluation of the effects of oral ibopamine (SB 7505) on cardiac and renal function in patients with congestive heart failure.

We investigated the effect of oral ibopamine (SB 7505) on myocardial and renal function in eight patients suffering from congestive heart failure. Ibopamine was administered orally 50 mg twice a day for 7 days. Systolic time intervals PEP (preejection period) and EMS (electromechanical systole) decreased significantly after each administration of ibopamine. Maximum reduction of systolic time intervals was observed 4 h after ibopamine administration. Statistically significant shortening was still apparent at 8 h. Twenty-four hour urinary volume was greater than control values on each day of ibopamine administration. The average daily increase in urine output was 70.2%. Sodium and potassium excretion increased. Each patient showed symptomatic improvement during therapy. No side effects attributed to ibopamine therapy were observed, and clinical laboratory values were unchanged. Tachyphylaxis was not observed during the period of treatment. We conclude that oral administration of ibopamine improves cardiovascular performance and renal function in patients with congestive heart failure.

Aged↗
PubMedDate not supplied

[Epidemiological study on coronary risk factors in a population of clerks in Parma. Methods of research and 1st results].

After a review of current literature, the AA. present the purposes and the methods of an epidemiological study on coronary risk factors in selected bank-clerks of Parma, in view to correlate the dietary factors, possible methabolic alterations, psychical behaviour, social and environmental position and coronary risk evaluated by electrocardiographic stress test. In this respect, the AA. report and discuss, as example of the reliability and validity of the investigative model followed, the preliminary results observed in the 274 subjects up to this time controlled.

Adult↗
PubMedDate not supplied

[Digitalis and heart failure].

The authors first discuss the predominant cardiovascular mechanisms of the action of digitalis from a historical point of view. They then deal with different clinical situations in which the use of digitalis is limited, such as cardiac insufficiency resulting from altered diastolic function, although further studies dealing with the ratio of digitalis to diastolic function are necessary to gain a better insight into this problem. Finally, the discussion focuses on various clinical trials (including recent studies) on the use of digitalis in cardiac compensation in subjects with sinus rhythm. While the drug seems useless, if not risky in the majority of patients, in others with cardiomegaly, III tone and fluid overload the effects of the drug still seem beneficial at the clinical level. In this case, however, improved cardiac performance could not be demonstrated. The extra-inotropic types of digitalis action are thus reexamined, and some are correlated with favourable clinical effects which can be encountered in some forms of chronic heart failure.

Clinical Trials as Topic↗