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Biomedical subjects

C Manca

Publications and source records attributed to C Manca.

At least 109 records · Page 6Linked to original sources
PubMed1980

[Arterial blood pressure in a population of Italian clerical workers. Correlation with other coronary risk factors].

Distribution of arterial blood pressure and prevalence of hypertension have been reported in 172 subjects (568 males and 144 females), derived from screening of a bank clerks population. 99 subjects were found to be hypertensive: 46 (46.4 p. 100) were aware of being hypertensive, 24 (24.3 p. 100) resulted to be under treatment and only in 5 subjects blood pressure values were effectively controlled. The relationships between arterial blood pressure and some recognized or suspected coronary risk factors were also determined by multiple regression analysis. Age, heart rate, body mass index, glycemia after loading, turned out the variables most correlated with blood pressure. The multiple regression analysis showed that overall evaluation of coronary risk factors explained up to 21 p. 100 of the systolic blood pressure variation and to 17 p. 100 of diastolic pressure in male subjects, while for women the obtained values were 34 p. 100 and 24 p. 100 respectively. After a critical evaluation of different parameters able to affect arterial blood pressure, the difficult approach to hypertension preventive and therapeutic problems was emphasized.

Adult↗
PubMed1980

[Exercise-induced R wave changes in normals and coronary patients. Computer analysis of CB5 lead (author's transl)].

Changes in R-wave amplitude (delta R) during treadmill test were studied in 84 coronary artery disease (CAD) patients and in 150 normal subjects. The evaluation of ECG recordings (CB5 lead) was carried out by a computer program. At maximal exercise, R-wave decreased by 2.1 +/- 2.8 mm in normal subjects, while in CAD patients mean delta R was significantly lower (0.4 +/- 1.7 mm). When the evaluation of delta R was performed at comparable heart rate and work load values, no significant differences were observed between normals and CAD patients. Using as criterion for a positive test an ischemic ST segment depression greater than or equal to 1.0 mm, the diagnostic sensitivity was 66.7%, while the specificity was 94.0%. When an increase or no change in R-wave was taken as evidence of an abnormal response, sensitivity and specificity values were 57.1% and 65.3% respectively. After a critical review of different parameters able to affect delta R, the difficult physiopathological evaluation and the poor diagnostic reliability of delta R were emphasized. The different heart rate and work load values attained by normals and CAD patients proved to be a further confounding factor in delta R comparison between the two groups.

Adult↗
PubMed1980

Non-invasive evaluation of left ventricular function through systolic time intervals following oral administration of SB 7505 in man.

An investigation on the effect of diisobutyric ester of N-methyl-dopamine (SB 7505) on systolic time intervals (STI), heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure(DAP), saluretic activity was carried out on 8 male volunteer in-patients who had normal renal, gastrointestinal, cardiac and hepatic functions and were free from other serious illness. SB 7505 was administered orally at three doses of 50, 100 and 150 mg. HR, SAP and DAP either showed no variations or marginal insignificant shifts. STI decreased evidencing a dose-related positive inotropic effect like digitalis, but shorter than digitalis. SB 7505 also showed diuretic action with all three doses investigated. The positive inotropic effect and diuretic activity point to the possible usefulness of SB 7505 in treating some heart and kidney diseases.

Administration, Oral↗
PubMed1980

Exercise testing in coronary artery disease with ST-segment abnormalities at rest.

In order to assess the diagnostic value of stress testing in patients with coronary artery disease (CAD) and ST abnormalities at rest, the results of a bicycle ergometer exercise, were compared in two groups of patients. Group 1 was composed of 58 CAD patients with normal resting ECG; group 2 was composed of 115 CAD subjects with abnormal ECG at rest. The latter group was then divided into three subgroups according to the absence (2a) or the presence (2b) of previous transmural myocardia infarction, or of previous transmural infarction with ST segment elevation at rest (3c). According to conventional exercise ECG criteria, the test was positive in 81% of group 1 and nearly in all the patients of group 2. In group 2 the prevalence of exercise-chest pain was constantly lower, particularly in subgroup 3c, in comparison with group 2. A greater prevalence of chest pain together with a greater severity of Gensini index were found in the subjects with positive exercise ECG in leads different from the impaired ones at rest. The diagnostic value of exercise ischemic changes location and of chest pain appearance, in patients with ST abnormalities at rest, is emphasized.

Angina Pectoris↗
PubMed1980

[Comparative evaluation of phonocardiogram and echocardiogram in mitral valve prolapse diagnosis (author's transl)].

In order to determine the correlation between echocardiography (ECHO) and phonocardiography (PHONO) in the evaluation of the Mitral Prolapse Syndrome (PM), 87 subjects with echo or phono criteria of PM were studied using both techniques. The phonocardiographic criteria used for PM diagnosis were the presence of a telesystolic click and/or a telesystolic murmur. The echocardiographic criteria were a telesystolic or holosystolic posterior movement of a mitral leaflet continuously seen through systole or of both mitral leaflets seen in part of systole. In the 63 patients with ECHO indicative of PM, the PHONO was positive in 55 cases (87%). Methoxamin administration, in 5 cases whose basal PHONO was normal, allowed the observation of 3 telesystolic murmurs and 2 clicks. The drug also diminished the number of clicks and increased tfhe telesystolic murmurs. In 79 subjects with PHONO indicative of PM, the ECHO was positive in 57 cases (72%): this technique was of particular value in patients with olosystolic murmur; valuable also to evaluate the diastolic diameter of the left ventricle and the left atrium and other signs having a possible use for a more accurate physiopatologic definition of the PM syndrome.

Adolescent↗
PubMed1979

Comparison of five different stress testing methods in the ECG diagnosis of coronary artery disease. Correlation with coronary arteriography.

Five different stress testing methods: bicycle ergometer exercise (BE), treadmill exercise (TD), isoproterenol infusion test (IPN), dopamine infusion test (DPM), and atrial pacing (AP), were performed on 90 male patients who underwent coronary arteriography. Ischemic S-T segment depression of 1.0 mm or greater was used as the criterion for a positive test. Within the group of 56 subjects having significant coronary artery disease (CAD) the diagnostic sensitivity of the single tests was as follows: 64.3% for BE, 66.1% for TD, 69.6% for IPN, 41.1% for DPM, 75.0% for AP. For the 34 subjects with no CAD the folowing specificity was found: 88.2% for BE and for TD, 82.3% for IPN, 85.3% for DPM, 63.8% for AP. When the results of the different tests were combined, it was seen that the association of an ergometric test with IPN enhanced the sensitivity of the exercise test (p less than 0.05) without significantly decreasing the specificity.

Adult↗
PubMed1979

[Metoprolol effect on ECG exercise test in patients with stable angina pectoris. Computer analysis (author's transl)].

The effect of metoprolol in ECG experiments induced by a treadmill exercise test, was studied in 30 patients with stable angina pectoris. The study was a simple blind cross-over between metoprolol (150 mg/die) and placebo. The evaluation of ECG recordings (V5 lead) was carried out by a computer program. In order to assess the ST-segment depression, the ST 0.8 (Depression at 80 msec after R-peak) and AST (ST area) values were used. We observed an increased exercise tolerance after administration of metoprolol (P less than 0.001) and a significant reduction of ST segment depression for ST 0.8 (P less than 0.01) and AST (P less than 0.005) at the maximal commun work load attained by every patient in the metoprolol and placebo tests. When the evaluation of ECG measurements were performed at the maximal commun double product no significant modifications were observed.

Adult↗
PubMed1978

Different prognostic value of exercise electrocardiogram in men and women.

In 1,455 subjects (947 men and 508 women) who underwent a bicycle ergometer stress test for evaluation of atypical chest pain, the incidence of coronary events (definite myocardial infarction or sudden death) was assessed by the life table method. The follow-up period ranged from 3 to 7 years (mean 5.2 years). In men with positive exercise test (ischemic ST depression greater than or equal to 1 mm), the 5-year incidence of coronary events was 18.3%, compared with 1.9% in negative responders. In women with positive response, the 5-year incidence of coronary events was 4.6%; in negative responders, it was 0.3%. The poor predictive value of ischemic ST responses to exercise in women is emphasized.

Adult↗