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Biomedical subjects

C M Flaitz

Publications and source records attributed to C M Flaitz.

At least 91 records · Page 5Linked to original sources
PubMed1993

White lichenoid lesions of the buccal mucosa in patients with HIV infection.

We report on eight patients who developed white lichenoid lesions of the buccal mucosa during the course of human immunodeficiency virus infection. In five patients the lesions appeared after the administration of zidovudine, in two after the intake of both zidovudine and ketoconazole, and in one after ketoconazole. In the majority of cases, lesions presented as bilateral reticular keratosis or atrophic changes of the buccal mucosa. Three patients manifested lichenoid atrophic changes of the dorsum of the tongue. The histopathologic features were hyperkeratosis, epithelial atrophy, basal cell liquefaction, and the presence in the lamina propria of either a patchy or diffuse lymphocytic infiltrate. All specimens tested negative for Epstein-Barr virus and human papillomavirus. Our study suggests that lichenoid lesions of the buccal mucosa, similar to what has been described as lichenoid drug reactions or idiopathic lichen planus, can be observed during human immunodeficiency virus infection and that administration of zidovudine and ketoconazole should be considered as a possible cause.

Adult↗
PubMed1993

Intraoral presentation of anaplastic large-cell Ki-1 lymphoma in association with HIV infection.

Persons infected with human immunodeficiency virus have an increased risk for development of high-grade, non-Hodgkin's lymphomas. Anaplastic large-cell Ki-1 lymphoma is a recently described lymphoid neoplasm characterized by cellular pleomorphism, a sinusoidal growth pattern, and Ki-1 epitope reactivity. This type of lymphoma is often mistaken for metastatic carcinoma, melanoma, or malignant histiocytosis. Although persons with acquired immunodeficiency syndrome frequently have non-Hodgkin's lymphoma at extranodal sites, the oral cavity and mandible, in particular, are unusual locations. We report two cases of anaplastic large-cell Ki-1 lymphoma that occurred in persons with the human immunodeficiency virus and with initial presentation as soft tissue masses of the posterior mandible. Immunocytochemical studies were positive for Ki-1 (CD30) in both cases. In situ hybridization for Epstein-Barr virus-deoxyribonucleic acid was positive with tumor cells in both cases. Flow cytometry on paraffin, formalin-fixed tissue revealed tetraploidy and high proliferative fractions that are characteristic of high-grade lymphomas. Intraoral presentation of rapidly enlarging, soft tissue masses may represent a high-grade non-Hodgkin's lymphoma in persons with the human immunodeficiency virus. Although rare, anaplastic large-cell Ki-1 lymphoma should be considered and requires immunocytochemical study to eliminate the possibility of other malignant conditions associated with the acquired immunodeficiency syndrome.

Adult↗
PubMed1993

Subcutaneous fat necrosis of the newborn and hypercalcemia: case report and review of the literature.

Subcutaneous fat necrosis of the newborn (SCFN) alone is an uncommon condition. Its association with hypercalcemia has been reported in 19 neonates since 1926. The two occur in full-term to postterm newborns with perinatal complications associated with delivery. Erythematous to violaceous, firm, subcutaneous nodules appear approximately 1 to 4 weeks after delivery, preceding the development of signs and symptoms of hypercalcemia. Although SCFN and hypercalcemia are rare complications in neonates with perinatal problems, death due to the sequelae of hypercalcemia occurred in 3 of the 19 patients. A neonate who develops skin lesions consistent with SCFN should be followed for possible onset of hypercalcemia and treated in a timely fashion.

Fat Necrosis↗
PubMed1993

Adenomatoid and calcifying epithelial odontogenic tumors.

The histologic diversity of the odontogenic epithelium's neoplasms is nicely illustrated by the adenomatoid and the calcifying epithelial odontogenic tumors. The former has a predilection for the maxilla, the latter for the mandible. Neither has a malignant variant, and each is controlled by conservative local removal. The recurrence rate of the adenomatoid odontogenic tumor is 0.2%, while the calcifying epithelial odontogenic tumor's rate is 14%.

Female↗
PubMed1993

Peripheral epithelial odontogenic tumors.

Peripheral epithelial odontogenic tumors are the extraosseous equivalents of the much more often encountered central gnathic odontogenic tumors. The peripheral tumors arise in the mandibular or maxillary gingiva from the surface mucosa or dental lamina rests in the submucosa. Ameloblastoma is the most common histologic type. It, like all other peripheral epithelial odontogenic tumors, follows a benign, nonaggressive clinical course.

Adolescent↗
PubMed1993

Treating Kaposi's lesions in the HIV-infected patient.

Kaposi's sarcoma is the most frequent malignant neoplasm in AIDS, occurring in about 10 percent of all risk groups. This study evaluates the effect of intralesional vinblastine on intraoral Kaposi's sarcoma in 24 HIV-positive, homosexual males with 82 lesions. Complete resolution occurred in nearly 70 percent of the cases.

Adult↗
PubMed1993

A possible late onset variation of Papillon-Lefèvre syndrome: report of 3 cases.

Three unusual cases of Papillon-Lefèvre syndrome with late onset of features and relatively mild periodontal disease are presented. These examples confirm some of the late onset of features and mild periodontal presentation of a previous case report. Bacteriologic associations, polymorphonuclear leukocyte chemotactic, phagocytic, and bactericidal activity, and therapeutics with regard to this syndrome are discussed.

Adult↗
PubMed1993

Caries-like lesion initiation and progression around laser-cured sealants.

This study evaluated and compared the effects of argon laser and visible light polymerization of a pit and fissure sealant material on caries-like lesion initiation and progression. Following the lesion initiation period, the primary surface lesion depth was significantly less (P < 0.05) for the argon laser-cured group (97 microns) when compared with that for the visible light-cured group (151 microns). Wall lesion occurrence was 5% for both treatment groups. Following lesion progression, the primary surface lesion depth was significantly less (P < 0.05) for the argon laser-cured group (129 microns) when compared with that for the visible light-cured group (232 microns). Wall lesion occurrence was 15% and 5% for visible light-cured and argon laser-cured groups, respectively (P < 0.05). Argon laser-curing of sealant material may enhance the caries resistance of the enamel forming the enamel-resin interface and result in a reduction in caries formation adjacent to sealants.

Argon↗
PubMed1993

Cementoblastoma.

Explore the source record for details and available documents.

Adult↗
PubMed1993

Sialolithiasis.

Explore the source record for details and available documents.

Adolescent↗
PubMed1993

Epidemiology of dental caries in the pediatric and adolescent population: a review of past and current trends.

Dental caries in the pediatric and adolescent population has continued to decline significantly over the past two decades, with approximately 50% of US schoolchildren considered to be caries-free. However, by the age of 17 years, only 15% of these young adults have not experienced caries. Over 85% of the lesions in the permanent dentition involve surfaces with pits and fissures, despite the availability of preventive measures such as sealants. Of particular interest is the fact that 17% of children and adolescents account for 67% of the total caries experience. This distribution of dental caries demonstrates the need for a reliable screening method to determine those individuals at high-risk for caries development. The identification of these caries susceptible children and adolescents, and the development of innovative, caries-preventive protocols are necessary for further improvement in the oral health status of the pediatric age group and creation of a caries-free population.

Adolescent↗
PubMed1993

Treatment of gold salt-induced oral lichen planus: report of a case.

A case of gold salt-induced oral lichen planus is reported. The oral lesions were successfully managed with a topical corticosteroid rinse. Gold salts, oral symptoms, and the use of the systemic inducing agent/immunosuppressant in combination with a topical corticosteroid are reviewed.

Adult↗
PubMed1992

Caries-like lesion formation around fluoride-releasing sealant and glass ionomer.

Caries-like lesion formation around Class V preparations restored with fluoride-releasing sealant, glass ionomer and conventional sealant materials was evaluated with polarized light microscopy following lesion initiation and progression periods. Significant differences (P < 0.05) were found among the three treatment groups for mean surface lesion depth following lesion initiation and progression and between the conventional sealant and fluoride-containing material groups for incremental increase in surface lesion depth following lesion progression. Surface lesion depths were significantly reduced in both the fluoride-releasing sealant and glass ionomer groups when compared with the conventional sealant group. The glass ionomer material provided the greatest degree of caries protection at the enamel-restorative interface and had the least number of wall lesions (7.5%); in contrast, the conventional sealant group had the greatest number of wall lesions (17.5%). The incorporation of fluoride from a dental material into adjacent tooth structure may provide enhanced resistance to caries initiation and progression.

Dental Caries↗