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Biomedical subjects

C M Boyd

Publications and source records attributed to C M Boyd.

At least 55 records · Page 3Linked to original sources

Sinus tract in the neck: a rare complication of subtotal thyroidectomy for Graves' disease.

The present report demonstrates a complication not previously reported secondary to thyroid surgery as a treatment of hyperthyroidism. This complication of a sinus tract extending 6 cm from the thyroid to the skin appeared to be due to a foreign body reaction to the sutures utilized in the operation. This sinus tract which extruded some sutures became infected with Staphylococcus aureus which prevented spontaneous closure. The formation of a sinus tract in the neck after a subtotal thyroidectomy for hyperthyroidism appears to be a much less common complication than the previously reported complications of bilateral abductor vocal fold paralysis, unilateral recurrent nerve paralysis, permanent post-operative hypoparathyroidism and thyroid storm secondary to this surgery, but the true incidence of sinus tract formation after thyroid surgery is unknown at present.

Female↗

Bremsstrahlung imaging after 32P treatment for residual suprasellar cyst.

A patient with residual suprasellar cystic neoplasm was treated by direct instillation of the 32P colloid. The incidental bremsstrahlung images on a conventional gamma camera helped to localize the pharmaceutical within and outside of the lesion. Advantages of bremsstrahlung imaging and the dosimetry results of phantom studies carried out are described.

Craniopharyngioma↗

Incidental hydronephrosis on bone scintigraphy: sonographic verification.

We studied 98 kidneys in 55 patients with bone scintiscans and renal sonography. Among the 29 kidneys in which hydronephrosis was suspected on bone scintiscans only 12 were truly hydronephrotic by renal ultrasound. In the other 17 cases extrarenal pelves, postural stasis, early urinary tract obstruction or renal parenchymal disease may have contributed to the discrepant findings. By ultrasound criteria there were no false negative readings for hydronephrosis on scintiscan. While it is safe to interpret absence of hydronephrosis caution should be used in diagnosing hydronephrosis, since less than half of the cases actually will have the disease when suspected on a bone scintiscan.

Bone and Bones↗

Use of intraoperative radionuclide study and colonoscopy in gastrointestinal hemorrhage.

Tc-99m labeled red cell imaging is used in the diagnosis and localization of gastrointestinal hemorrhage. A patient in whom a preoperative scan was positive in the right paraumbilical region is discussed. Intraoperative Tc-99m labeled red cell imaging was used in conjunction with colonoscopy, and the site of active bleeding was found in the proximal transverse colon, which had been displaced downward because of adhesions.

Colonoscopy↗

Role of delayed indium-111 labeled leukocyte scan in the management of Crohn's disease.

Comparison of nine patients with Crohn's disease who had a positive delayed (24 hr) 111indium leukocyte scan and 10 patients with negative scan showed no significant difference between the two groups for the Crohn's disease activity index, sedimentation rate, survival, complications, number of days in hospital, outpatient visits, or readmissions. Despite the apparent lack of statistical significance in Crohn's disease activity index, the scan was positive in nine of 16 patients with a Crohn's disease activity index more than 150, and none of three patients with Crohn's disease activity index less than 150. In the patients studied, there were no false-positive leukocyte scans. In nine of 10 patients with ileocolonic disease, scanning results correctly predicted the proper management. Six patients with positive scan and enteroclysis responded to medical treatment. Four patients had positive enteroclysis and negative scan; of these, three had radiographic features of chronic ileal stricture which was confirmed at operation. The results suggest that a negative delayed indium-111 leukocyte scan may be useful in diagnosis of chronic fibrotic ileal stricture.

Adult↗

Relation of right ventricular ejection fraction to exercise capacity in chronic left ventricular failure.

Although the left ventricle is traditionally viewed as the heart's main pumping chamber, no correlation has been shown between left ventricular (LV) ejection fraction (EF) at rest and exercise capacity in patients with chronic LV failure. Because vasodilators with venodilating activity increase exercise capacity more than predominant arterial dilators in patients with LV failure, right ventricular (RV) function may relate to exercise capacity in these patients. In 25 patients with chronic LV failure, caused by coronary artery disease in 12 patients and idiopathic dilated cardiomyopathy in 13 patients, RVEF and LVEF at rest were measured by radionuclide angiography. Maximal upright bicycle exercise testing was also performed to determine maximal oxygen consumption, which averaged only 13 +/- 4 ml/min/kg. The LVEF at rest was 26 +/- 10% and did not correlate with maximal oxygen consumption (r = 0.08). However, the RVEF was 41 +/- 12% and correlated with maximal oxygen consumption (r = 0.70, p less than 0.001) in the same patients. The correlation was stronger (r = 0.88) in patients with coronary artery disease than in those with idiopathic dilated cardiomyopathy (r = 0.60). Thus, RVEF at rest is more predictive of exercise capacity than LVEF in the same patients with chronic LV failure. These results are consistent with the clinical observation that only venodilating agents increase exercise capacity of patients with chronic LV failure.

Cardiac Output↗

Unsuspected extra-abdominal sites of infection: scintigraphic detection with indium-111-labeled leukocytes.

Scintigraphy with indium-111-labeled leukocytes (In-111-WBC) was assessed in 128 patients with suspected abdominal-pelvic abscesses. Studies were positive in 37 of 41 patients with proved abscesses, in two of two with infected aortic grafts, and in 12 of 15 with other infections; studies were negative in 63 of 70 cases without infection. The sensitivity of leukocyte scintigraphy in this series was 88%, specificity 90%, and accuracy 89%. Sixteen percent of all patients studied with In-111-WBC scintigraphy had unexpected sites of infection outside the abdomen. Of the 58 patients with proved infection, 20 (34%) had alterations in diagnostic evaluations and therapeutic regimens due to such findings.

Abdomen↗

Angiography of pulmonary emboli: digital studies and balloon-occlusion cineangiography.

The value of digital pulmonary arteriography and balloon-occlusion cineangiography was investigated in 118 selected patients. In one series of 40 patients, digital pulmonary arteriography correctly identified pulmonary emboli in 20 (75%) of 26 positive examinations when interpretation was confined to the first three divisions of the pulmonary artery. In a second series of 78 patients with peripheral radionuclide perfusion scan defects, 40 of whom had pulmonary emboli, adjunctive balloon-occlusion cineangiography demonstrated emboli in four patients not seen on standard selective catheter pulmonary magnification studies with cut films. These two procedures (i.e., digital pulmonary arteriography and balloon-occlusion cineangiography) are important adjuncts to radionuclide perfusion scans and selective catheter pulmonary arteriography in the evaluation of patients with pulmonary emboli.

Angiography↗

Eosinophilic granulocytes as a possible source of vitamin B12-binding protein.

Leucocyte B12 and B12-binding capacity were measured by Simultrac radioassay in eosinophilic granulocytes, neutrophilic granulocytes and leucocytes obtained from patients with chronic granulocytic and lymphocytic leukaemia. It is shown that (a) eosinophils are a possible source of B12-binding protein similar to neutrophils and (b) granulocytes in myeloproliferative disorders and normal neutrophils have similar B12 and B12-binding capacity indicating that increased B12 and B12-binding capacity in myeloproliferative disorders arise from an increase in myeloid cell turnover.

Eosinophilia↗