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Biomedical subjects

C Lundberg

Publications and source records attributed to C Lundberg.

At least 145 records · Page 8Linked to original sources
PubMed1981

Regional differences in skin blood flow as measured by radioactive microspheres.

Regional skin blood flows in the trunk were measured by means of radioactive labeled microspheres in anesthetized rats and monkeys. Mean arterial pressure, heart rate, cardiac output and arterial pH, pO2 and pCO2 were registered and body and ambient air temperature were kept constant for the duration of the experiments. The blood flows were determined on a total of 6 skin samples, 2 samples each from the thoracic, lumbar and sacral regions. The reproducibility of the microsphere technique for measurements were given with a 10 min interval. The coefficient of variation varied with the region from 10.3 to 22.7%. In both species the skin blood flows in the thoracic regions were significantly higher than in the lumbar and sacral regions (P less than 0.05). The skin blood flows in the thoracic region of the rat ranged from 39-45 ml.min-1.100 g-1, in the lumbar region from 32-33 and in the sacral region from 29-30. In the monkeys the corresponding values for the different regions were: thoracic: 7-9, lumbar 5-7 and sacral: 4-7 ml.min-1.100 g-1, respectively. Our results support the use of radioactive microspheres for skin blood flow measurements, and demonstrate the existence of regional differences in the skin blood flow of the trunk. We suggest that this may be an important consideration during the development, and interpretation of data from experimental models in which skin blood flow is important.

Animals↗
PubMed1981

Tinidazole in the treatment of infections of the upper respiratory tract.

Sixteen patients with primary or secondary anaerobic infections of the maxillary sinus, mouth and throat were treated with tinidazole. The peak plasma concentration in eight patients given 2 g tinidazole initially followed by 1 g daily on the 5 subsequent days varied between 15 and 48 microgram/ml the first day and were only slightly lower during the following days. The mixed saliva/plasma concentration ratios ranged between 0.2 and 1.8 with a mean value of 0.85. In eight patients with anginose infectious mononucleosis, a rapid improvement was observed after the onset of treatment. Normal body temperature and well-being was restored within 3 to 5 days. No bacteria considered to be involved in the infection of the throat were isolated from these patients, and it, therefore, seems unlikely that the clinical benefit is attributable only to antibacterial activity of tinidazole. Anaerobic infections in five patients with purulent maxillary sinusitis, two patients with acute exacerbation of atrophic pharyngitis and one patient with a necrotic ulcer of the tongue, were treated successfully with tinidazole.

Adult↗
PubMed1980

Dental sinusitis.

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Diagnosis, Differential↗
PubMed1979

Bacterial adherence to epithelial cells in the nasopharynx in children.

The presence of attached bacteria to epithelial cells from the nasopharyngeal surface of the soft palate, from the adenoid surface and from the secretions covering the adenoid was studied in 10 children undergoing adenoidectomy. Large numbers of bacteria were seen to attach to mature normal squamous epithelial cells from the soft palate and in the secretions, whereas attachment to adenoid epithelial cells was rare. Using differential interference contrast microscopy, bacteria-carrying epithelial cells were seen to have their surface covered by microridges characteristic of normal mature squamous epithelial cells. Sections of adenoid tissue showed bacterial infiltration of adenoid tissue to be virtually nonexistent in the patient group.

Adenoidectomy↗
PubMed1979

Anaerobic bacteria in maxillary sinusitis.

The anaerobic bacterial flora of purulent maxillary sinusitis was investigated in 30 patients and the different anaerobic species identified and tested with respect to antibiotic susceptibility. Most strains were identified as anaerobic cocci. Non-sporeforming Gram-positive rods and Gram-negative rods other than Bacteroides fragilis were also isolated. The majority of the strains were susceptible to benzylpenicillin, cefoxitin, clindamycin, doxycycline, metronidazole and chloramphenicol.

Anti-Bacterial Agents↗
PubMed1978

Antibiotic concentrations in saliva of purulent parotitis.

In patients with unilateral acute purulent parotitis treated with penicillin and doxycycline the antibiotic concentration was determined in plasma and saliva from both the healthy and the affected parotid gland. The results show that the penicillin concentrations in purulent saliva of the diseased gland is considerably higher than in non-purulent saliva of the healthy parotid gland. There was no such marked difference in concentrations of doxycycline. The possible mechanisms behind these observations are discussed as are the conclusions that can be drawn concerning treatment of acute purulent and chronic recurrent parotitis.

Acute Disease↗
PubMed1976

Aspects of the treatment of maxillary sinusitis.

The elimination of bacteria from sinus secretion during antibiotic treatment and the biological environment in the sinus as regards pO2 and pCO2 of sinus secretions were studied. Elimination of bacteria was achieved only, but not invariably, when the antibiotic concentration in the secretion greatly exceeded the MIC values of the bacteria isolated. Bacteriostatic and bactericidal antibiotics were equally effective. In purulent secretions as opposed to nonpurulent secretions the pO2 was always zero or close to zero, and the pCO2 was always higher than, and sometimes more than twice as high as the pCO2 of venous blood. In view of these observations, antibiotic therapy resulting in a high antibiotic concentration in the secretion is advocated in the treatment of purulent maxillary sinusitis. Furthermore, drainage and aeration of the sinus cavity is to be regarded as an important complement to the antibiotic therapy.

Anti-Bacterial Agents↗
PubMed1975

Penicillin treatment in oral surgery in patients with coagulation disorders.

There are clinical observations indicating that the frequency of postoperative bleeding after oral surgery in patients with coagulation disorders is reduced by prophylactic antibiotic treatment. To assess this effect, the concentrations of phenoxymethylpenicillin in plasma and saliva were determined during treatment and compared with the MIC values for penicillin of the oral bacteria of four patients with coagulation disorders. The concentration of penicillin in plasma of the patients considerably exceeded the MIC values of all isolated bacteria. In mixed saliva and saliva of the parotid and submandibular glands no penicillin activity could be detected. The bacteria isolated from the oral cavity of the patients did not in vitro exhibit either fibrinolytic or plasminogen activator activity. Thus, the oral bacteria of patients with coagulopathies probably do not cause an increased bleeding tendency by their intra- or extracellular enzymes.

Bacterial Physiological Phenomena↗
PubMed1975

Antibiotic concentrations in maxillary sinus secretions and in the sinus mucosa.

In maxillary sinusitis, the blood circulation is supposed to be impaired in the oedematous sinus mucosa, and in such cases the transport of antibiotics into the maxillary sinus should be reduced. To prove the accuracy of this assumption a comparison has been made between the concentrations of penicillin and doxycycline (Vibramycin, Pfizer) in sinus mucosa and secretions and the serum concentrations in patients under treatment with these antibiotics. Measureable concentrations of penicillin (greater than 0.2 mug/ml) were reached in the secretions only if the serum concentration was high (greater than 4-5 mug/ml). In contrast, measurable concentrations of doxycycline were achieved in both mucosa and secretions in all patients treated with this antibiotic. This must depend on the fact that doxycycline, due to its optimal lipid solubility, was able to penetrate poorly vascularized tissue. In most cases, the concentrations of doxycycline far exceeded the minimum inhibitory concentrations of the isolated organisms, and in some cases the local concentrations were higher than those found in the serum. The clinical response to doxycycline was good and correlated well to the laboratory data.

Doxycycline↗
PubMed1975

Evaluation of the antibiotic effect of treatment of maxillary sinusitis.

As the effect of antibiotic treatment of maxillary sinusitis has been questioned, the elimination of bacteria from sinus secretions was studied during antibiotic treatment. Penicillin V, azidocillin, tetracycline or doxycycline was administered to 54 patients with maxillary sinusitis. Samples of sinus secretion were aspirated both before treatment and 2-3 days after the onset of treatment. When the antibiotic concentration was below the upper limit of MIC for sensitivity group 1, bacterial growth was present in practically all samples. When the antibiotic concentration equalled or was above this limit, there was no bacterial growth in about half of the samples. A prerequisite for antibiotic effect--elimination of bacteria--is that the antibiotic concentration is well above the MIC of the bacteria at the site of infection. The choice between bactericidal or bacteriostatic antibiotics appeared unimportant. Bacterial survival in the maxillary sinus despite a high antibiotic concentration in the sinus illustrates that MIC values determined in the laboratory do not always mirror the sensitivity of bacteria to antibiotics in vivo.

Anti-Bacterial Agents↗
PubMed1975

Sexual functions of mice neonatally exposed to DDT or pcb.

Since DDT and PCB occur in milk, young animals may ingest these substances during the critical period of neonatal life; For this reason lactating mice were given injections of DDT or PCB, 50 mg/kg body weight, once a week for four weeks, the first injection being administered on the day of delivery. The reproductive capacity of their young was studied by measuring the frequency of implanted ova. When both the male and the female of a mating pair had been nursed by DDT- or PCB-treated mothers this frequency decreased from 94% in the controls to 79 and 75% respectively. No significant decrease were found when only one of the mated animals in the pair had been nursed by a treated mother.

Animals↗