Search PubMed⌕ Search

Biomedical subjects

C L Jiang

Publications and source records attributed to C L Jiang.

52 records · Page 3Linked to original sources
PubMed1994

[The role of brain cholinergic system in renal sodium, potassium and water excretion in rats].

In anesthetized rats intracerebroventricular (i. c. v.) injection of cholinergic agonist carbachol induced significant natriuresis, kaliuresis and diuresis (P < 0.05). Among them, the degree of natriuresis was changed with carbachol in a dose-dependent manner (r = 0.9997, P < 0.05). These responses were completely blocked by cholinergic M receptor antagonist atropine or N receptor antagonist hexamethonium pretreatment. Such effects of carbachol were inhibited in part by pretreatment with adrenergic alpha receptor antagonist phentolamine. These results indicate that the natriuresis, kaliuresis and diuresis induced by i. c. v. injection of carbachol were primarily mediated by both muscarinic and nicotinic receptors in the brain, while the effect was in part mediated secondarily via adrenergic alpha receptor.

Animals↗
PubMed1992

[Characterization of a surface antigen of Plasmodium falciparum merozoite with monoclonal antibody].

The monoclonal antibody (McAb) designated as C6 against erythrocytic stage of Plasmodium falciparum Fcc7801/HN showed significant growth inhibition of P. falciparum in vitro, having cross immunofluorescence reaction with P. falciparum Fcc-1/HN, Fcc7802/HN, Fcc8703/JS and P. berghei, P. cynomolgi. McAb C6 bound to the antigen distributed evenly over the entire surface of merozoites of P. falciparum, as demonstrated by immunoelectron microscopy. The McAb C6 also recognized a single protein of 71 kDa of P. falciparum by Western blotting. This antigen might be a candidate of malaria vaccine.

Animals↗
PubMed1991

Preliminary observations on the epidemiology of bovine ephemeral fever in China.

Bovine ephemeral fever (BEF) is a viral disease of cattle and water buffalo recognised for the first time in China in 1955. The disease has been endemic in south China with 13 epidemics since 1955, seven epidemics reaching central China and one extending into north-east China (40 degrees N). The outbreaks have been seasonal with all occurring in the warmer summer/autumn months of June to October when possible insect vectors are active. Reports of clinical disease were confirmed as BEF by the detection of virus-neutralising antibody. The economic impact of the disease includes loss of milk production, late-term abortions and the loss of draught animal power.

Animals↗
PubMed1989

[Studies on actinomycete flora and resources in the plateau lakes in Yunnan].

During the period of 1983 to 1987 mud and water samples were collected from 12 larger lakes on the Yunnan Plateau. The actinomycetes in both sediment and water samples were investigated. Strains producing metabolites were screened by various procedures. The results are as follow: 1. The number and composition of actinomycetes in a lake were found to have relation to the physical and chemical features of the water-body. On the basis of the number and generic diversity of actinomycetes, lakes were thus divided into four groups. 2. Micromonospora occupied a notable domonance in benthic samples taken from all 12 lakes. This is a conspicuous characteristics of actinomycete flora in these lakes. 3. The population of actinomycetes in Lakes Qilu, Yilong and Datun ranges from 2991 to 3542 X 10(3)/g dry wt. of mud. 4. Strains of Actinomadura, Microtetraspora, Micropolyspora, Saccharomonospora and Saccharopolyspora were isolated. These genera were not previously reported in similar studies abroad. In addition, five species were considered to be new to science: Micromonospora phaeovirida Jiang et Xu, 1985 Saccharomonospora yunnanensis Jiang et Xu, 1985 Microtetraspora flavorosea Jiang et Xu, 1986 Actinomadura chenghaiensis Jiang et Xu, 1986 Actinomadura viridoflava Jiang et Xu, 1986 5. Studies indicate that actinomycetes possibly play an important role in the decomposition of chitin, cellulose and some toxic substances in lakes. 6. As freshwater resources, actinomycetes produce various useful metabolites such as fibrinolysine, and milk-clotting enzyme.

Actinomycetaceae↗
PubMed1987

Preliminary studies of the complement fixation test to confirm the diagnosis of bovine ephemeral fever.

A strain of bovine ephemeral fever (BEF) virus isolated in China in 1976 was adapted to growth in tissue cultures. A baby hamster kidney complement fixing (CF) antigen, stable at -20 degrees C for at least 120 days, was prepared from the BEF virus grown in tissue culture and used to test bovine sera for antibodies to that virus. CF antibodies were detected in all of 31 cattle after convalescence from experimental infection with BEF virus, in 208 (98%) of 213 cattle observed to have shown clinical ephemeral fever in an epidemic, in 96 cattle in these herds which did not show clinical signs of ephemeral fever and 16 cattle from herds in northern China outside the epidemic area. The CF antibodies to BEF virus were found to persist in 34 (89%) of 38 cattle which were bled 6 years after natural exposure to ephemeral fever. The CF antigen is economical to prepare and is suitable to differentiate ephemeral fever from other viral infections with which it could possibly be confused on clinical appearance.

Animals↗
PubMed1985

Effect of meal volume and energy density on the gastric emptying of carbohydrates.

Gastric test meals of Polycose, with volumes of 300, 400, and 600 ml and energy densities of 0.5, 0.7, 1.0, 1.3, 1.5, and 2.0 kcal/ml, were given to 21 men and recovered after 30, 60, or 120 min. Polycose, a polymer of glucose, was chosen as a soluble homolog of food. The results of 1134 Polycose meals were analyzed in terms of the rates of energy delivery to the duodenum. The rates of emptying in the initial 30 min were significantly greater than in either the 30-60- or 60-120-min periods. Increases in either energy density or meal volume increased the rate of energy delivery in all time periods (p less than 0.001). The steady rate of energy delivery, which was evident after the initial 30 min, was correlated with increases in the initial meal volume and energy density, such that doubling the volume of meals from 300 to 600 ml increased the rate of emptying by a mean of 0.72 kcal/min, whereas doubling the energy density of the meals from 0.7 to 1.3 kcal/ml raised the rate of emptying by 0.62 kcal/min, with an overall mean rate of caloric emptying of 2.5 kcal/min. Thus, increases in either the initial volumes or the energy densities of the test meals significantly increased the rate of acceptance of energy by the duodenum.

Dietary Carbohydrates↗
PubMed1984

Intrinsic emptying pattern of the human stomach.

Twenty-three subjects were given a total of 336 meals of 750 ml saline that was recovered at 5, 10, and 20 min to determine the intrinsic gastric emptying pattern. Minimal slowing of gastric emptying by duodenal receptors resulted from 120 mM NaCl. Analysis of the residuals from the within-subject regressions for every subject's remaining volume vs. time showed that the exponential model of gastric emptying most appropriately described the data when the volume instilled at time 0 was included.

Adult↗
PubMed1983

Gastric bleeding and gastric secretion with sulindac and naproxen.

We have examined concurrent gastric secretory rates and bleeding by a gastric wash technique during treatment with naproxen, sulindac, and placebo. Twelve subjects, in each of 4 treatment periods, took either placebo, sulindac 200 mg, naproxen 250 mg, or naproxen 375 mg, twice a day for four days. Of the resultant 192 days (12 subjects, 4 drugs, 4 days/drug), two thirds of all days showed bleeding at a rate less than 0.5 ml/day; this low rate of bleeding was seen with all treatments. In spite of this minor bleeding, we were able to show statistically significantly less bleeding with placebo than with drugs; placebo never resulted in a maximum rate of bleeding for any subject. Distinctions between drugs on the basis of bleeding, however, were not possible. Correlations between outputs of acid and chloride were not significantly affected by any of these drugs. In contrast to previous results with aspirin, no correlation between rates of bleeding and gastric secretion could be established. The low water solubility of these drugs at the pH of gastric contents may account for their causing very little bleeding. In effect, the greater the gastric secretion of acid the less the absorption through the gastric mucosa.

Aspirin↗
PubMed1983

Effect of synthetic prostaglandin E1 analog on aspirin-induced gastric bleeding and secretion.

Twelve healthy subjects were given aspirin (975 mg four times a day) for four days. On days three and four, each dose of aspirin was preceded by a synthetic protaglandin E1 analog (misoprostol, Searle) either 25 micrograms, 50 micrograms, or placebo in a double-blind balanced full crossover design. Bleeding, gastric secretion of acid and chloride, and accumulation of gastric luminal DNA and calcium as indices of cell shedding and mucus secretion were measured by three daily morning gastric washouts, corrected for gastric emptying. Both bleeding and gastric secretion were greater on day 4 with aspirin and placebo than on day 0. With 50 micrograms misoprostol, and to a lesser extent with 25 micrograms, bleeding and gastric secretion were reduced on day 4 compared to day 4 with placebo or aspirin only days. The reduction in gastric bleeding with the 50-microgram dosage of misoprostol was directly related to the reduction in acid secretion. The ratios of changes in acid and chloride outputs did not indicate any increase in bicarbonate secretion. No changes in the recoveries of calcium or DNA were seen.

Alprostadil↗
PubMed1983

The relation between freely chosen meals and body habitus.

By bomb calorimetry, we conducted a 7-day study of the energy contents of the freely chosen meals of 11 male subjects under their ordinary living conditions. Their body weights ranged from 60 to 99 kg and Quetelet indices ranged from 211 to 271 X 10(-5). Despite the wide range of body weight, there was no relation between daily energy intake and body weight, height, or Quetelet index. However the thickset subjects took diets and meals with higher energy density than the lean subjects (p less than 0.05 one-tailed for diets, p less than 0.025 one-tailed for meals). On average, the energy of lunch and dinner contributed 26 and 44% of daily energy, respectively. There was a significant negative relation between the energy of lunch and that of dinner (p less than 0.01), but no significant association between weight of lunch and that of dinner (p greater than 0.1).

Adult↗
PubMedDate not supplied

Interleukin-2 and its effects in the central nervous system.

Interleukin-2 (IL-2) is not only an important immunoregulatory molecule: it is also an important neuroregulatory molecule in the CNS. Investigations in vivo and in vitro have elucidated the following: IL-2 and IL-2 receptors (IL-2R) have been detected in the brain; IL-2 promotes survival and neurite extension of cultured neurons, stimulates oligodendrocyte proliferation and maturation, affects the hypothalamic-pituitary function and produces behavioral and electrocorticogram spectrum changes. Investigations in some laboratories, including ours, have also demonstrated an analgesic effect of IL-2 in the CNS. The molecular structure of the analgesic domain of IL-2 is distinct from the immune domain mediating immunoregulatory effects. A possible mechanism of action of cytokines on the CNS and the immune system or both exists: multiple actions of cytokines could be mediated by distinct domains or functional sites of cytokines interacting with different receptors or receptor subtypes.

Analgesics, Non-Narcotic↗