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Biomedical subjects

C L Cooper

Publications and source records attributed to C L Cooper.

At least 91 records · Page 5Linked to original sources
PubMed1988

The impacts of positive psychological states on physical health: a review and theoretical framework.

While much research has focused on the impacts of negative psychological states, such as stress, on physical health, relatively little research has examined the effects of positive psychological states. We suggest this imbalance is attributable to inadequate theoretical and methodological development regarding the impacts of positive psychological states on health. This paper presents a framework by which positive psychological states may influence physical health. Following this, we review evidence pertaining to this framework. We conclude by discussing methodological issues associated with this relatively new area of inquiry.

Adaptation, Psychological↗
PubMed1988

The transition to parenthood in dual-earner couples.

The impact of the transition to parenthood for dual-earner couples was examined in a longitudinal study. Data were collected by questionnaire from couples expecting their first child, during pregnancy and after maternity leave, and from childless couples at two separate time points. The impact of the transition was minimal overall, although women experienced more pressure than men and there were some cases of extreme stress. New single-earner parents reported a greater decline in life satisfaction than dual-earners.

Adaptation, Psychological↗
PubMed1988

A structural model approach toward the development of a theory of the link between stress and mental health.

This study attempts to develop an empirical model of the link between stress and mental health, focusing particularly on occupational stress. Three different models were assessed-the person-stress model, the dispositional model, and the indigenous model--using structural equation modelling. The indigenous model was found to be the most predictive of mental health. In this model, personality and coping strategies precede and determine the perception of job stressors, which ultimately affect the mental well-being of the individual.

Adaptation, Psychological↗
PubMed1988

Stress, mental health & job satisfaction among nurse managers.

This study investigated sources of stress and their effects on mental health and job satisfaction among nurse managers in the United States. One hundred and forty-four nurse managers completed questionnaires containing information concerning three kinds of variables: the degree of stress experienced at work, the personality of the individual, and characteristics of life situations away from work. It was found that in general the nurse managers were satisfied with their jobs, although they reported high stress on the job. They reported better mental health than normative groups. Using multivariate analysis, it was found that all three types of variables were necessary for prediction of mental health and job satisfaction. This finding supports the person-environment fit theory of occupational stress.

Administrative Personnel↗
PubMed1988

Job satisfaction and occupational stress among general practitioners--a pilot study.

Questionnaires assessing levels of job satisfaction and possible sources of stress were distributed to a random sample of general practitioners in the Greater Manchester area. The highest levels of job satisfaction were reported for ;intrinsic' job factors such as freedom to choose method of working, amount of responsibility and amount of variety, rather than ;extrinsic' factors such as rate of pay and hours of work. The main causes of stress appeared to be interruptions of various kinds. Factor analysis revealed four major sources of stress: interruptions; emotional involvement; administrative workload and work/home interface; and routine medical work. Of these, all but routine medical work were associated with job satisfaction. It is concluded that the major sources of stress for the general practitioner are not medical, but social.

Adult↗
PubMed1988

Portal venous air: a benign occurrence.

Air in the portal venous system after a colonic examination (colonoscopy or barium enema) or umbilical vein catheterization is a benign, selflimiting condition. The underlying intestinal pathology, however, is important in determining the status of the patient. Supportive treatment and antibiotic therapy is all that is needed for these patients.

Adult↗
PubMed1987

Purification and characterization of Rhodobacter sphaeroides acyl carrier protein.

Acyl carrier protein (ACP) has been purified from the facultative phototrophic bacterium Rhodobacter sphaeroides. The ACP preparation was greater than 95% homogeneous as determined by native and disodium dodecyl sulfate (Na2DodSO4)-polyacrylamide gel electrophoreses and N-terminal amino acid analysis. Amino acid compositional analysis revealed that the protein contains approximately 75 amino acids, has a calculated minimum molecular weight of 8700, and lacks the amino acids tyrosine and tryptophan. The presence of the characteristic 4'-phosphopantetheine prosthetic group was indicated by the occurrence of equimolar quantities of beta-alanine and taurine in amino acid hydrolysates and was confirmed by independent chemical analysis. The protein displayed a pI of 3.8 and had a calculated partial specific volume of 0.732 mL/g. The primary structure of the protein has been determined for the first 46 amino acid residues from the N terminus of the molecule, and the region of the molecule encompassing the amino acids from residues 31 to 44 was found to have 100% homology with the identical residues in Escherichia coli ACP. In contrast to E. coli ACP, R. sphaeroides ACP migrated according to its molecular weight during Na2DodSO4 gel electrophoresis, was resistant to pH-induced denaturation, and comigrated with the cis-vaccenoyl-ACP derivative during native gel electrophoresis. It is proposed that the basis for these properties is the enhanced hydrophobic character of the protein.

Acyl Carrier Protein↗
PubMed1987

Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac tissue.

The dihydropyridine-sensitive voltage-dependent Ca2+ channel from cardiac tissue was purified 900-fold using DEAE-Sephadex A-25, concanavalin A-Sepharose, and wheat germ agglutinin-Sepharose. The purified preparation was highly enriched in a peptide of 140,000 daltons when electrophoresed on sodium dodecyl sulfate gels in the presence of 2-mercaptoethanol, or 170,000 when electrophoresed in the presence of iodoacetamide. Polyclonal antibodies raised against the purified subunits of the rabbit skeletal muscle Ca2+ channel recognized the 170-kDa protein in preparations electrophoresed under nonreducing conditions, and the large peptide of 140 kDa and smaller peptides of 29-32 kDa in preparations analyzed under reducing conditions. Monoclonal antibodies, which were raised against the native Ca2+ channel from skeletal muscle, immunoprecipitated [3H]PN 200-110 binding activity from solubilized cardiac membranes and immunoprecipitated 125I-labeled peptides (from the purified cardiac Ca2+ channel preparation) which migrated as a single species of 170 kDa under nonreducing conditions, or as 140, 32, and 29 kDa under reducing conditions. The results show that the purified cardiac Ca2+ channel, like that previously purified from skeletal muscle, consists of a major component of 170 kDa which is comprised of a 140-kDa peptide linked by disulfide bonds to smaller peptides of 32-29 kDa. Peptide maps of the 140-kDa peptide purified from cardiac and skeletal muscle preparations were strikingly similar, suggesting a high degree of homology in their primary sequence.

Animals↗
PubMed1987

Measurement of catecholamines, indoleamines, thyrotrophin releasing hormone and substance P in rat and human spinal cord using a common extraction method.

An extraction method is described that allows the measurement of 5-hydroxyindoleacetic acid, dopamine, noradrenaline, substance P and thyrotrophin releasing hormone in the same sample of rat or human spinal cord. The substances were extracted using a mixture of 45% ethanol/0.1 M acetic acid and 0.02% sodium metabisulphite. The amines were then measured using high performance liquid chromatography with electrochemical detection and the peptides by radioimmunoassay. The common extraction method makes maximum use of limited postmortem material, reduces assay time and allows study of the interrelationships between the amines and peptides in rat or human spinal cord.

Animals↗
PubMed1987

Fatty acid metabolism in sn-glycerol-3-phosphate acyltransferase (plsB) mutants.

Fatty acid metabolism was examined in Escherichia coli plsB mutants that were conditionally defective in sn-glycerol-3-phosphate acyltransferase activity. The fatty acids synthesized when acyl transfer to glycerol-3-phosphate was inhibited were preferentially transferred to phosphatidylglycerol. A comparison of the ratio of phospholipid species labeled with 32Pi and [3H]acetate in the presence and absence of glycerol-3-phosphate indicated that [3H]acetate incorporation into phosphatidylglycerol was due to fatty acid turnover. A significant contraction of the acetyl coenzyme A pool after glycerol-3-phosphate starvation of the plsB mutant precluded the quantitative assessment of the rate of phosphatidylglycerol fatty acid labeling. Fatty acid chain length in membrane phospholipids increased as the concentration of the glycerol-3-phosphate growth supplement decreased, and after the abrupt cessation of phospholipid biosynthesis abnormally long chain fatty acids were excreted into the growth medium. These data suggest that the acyl moieties of phosphatidylglycerol are metabolically active, and that competition between fatty acid elongation and acyl transfer is an important determinant of the acyl chain length in membrane phospholipids.

Acyl Coenzyme A↗
PubMed1987

Evidence that bradykinin stimulates renal prostaglandin synthesis by a mechanism distinct from that of other vasoactive substances.

Arginine-vasopressin (AVP), angiotensin II (AII), and norepinephrine (NE) are known to stimulate prostaglandin (PG) synthesis in the intact rat kidney perfused with Tyrode's solution by a mechanism that requires intracellular Ca2+, while PG synthesis elicited by bradykinin (BK) is independent of Ca2+. To elucidate further the differences in the mechanism of action of BK and other vasoactive agents, in this preparation we have investigated the effect of caffeine, an agent known to interfere with the uptake and storage of Ca2+ in intracellular sites, on renal output of PGE2 and 6-keto-PGF1 alpha elicited by AVP, AII, NE, and BK; various combinations of the maximal doses of BK, AII, AVP, and NE on renal PG synthesis; and RHC 80267, an inhibitor of diglyceride and monoglyceride lipase, on the output of PGs produced by these vasoactive agents. Infusion of 1 mM caffeine inhibited PG output elicited by AVP, AII, and NE but not that caused by BK in the absence of extracellular Ca2+. Combined administration of maximal doses of BK (2.8 nmol) with that of AII (0.28 nmol), AVP (0.27 nmol), or NE (3.2 nmol) but not AVP and AII, NE and AVP, or NE and AII produced an additive effect on renal PG output in the presence or absence of Ca2+. The renal vasoconstrictor effect of AVP, AII, and NE produced in the presence of Ca2+ was not additive and remained unaltered when given together with BK.(ABSTRACT TRUNCATED AT 250 WORDS)

Angiotensin II↗
PubMed1987

Coping with pilot stress: resting at home compared with resting away from home.

This study assessed the impact of "resting at home" vs. "resting away from home" among 272 British commercial airline pilots. The purpose of the investigation was two-fold; to see whether resting at home and resting away from home are equivalent in the quality of rest they provide pilots (in view of the increasing trend in the industry for encouraging pilots to "rest while away from home base"); and second, to highlight the factors that may be predictive of poor mental health and mood shifts while resting away or at home. On balance, pilots away from home managed to rest, but not really to relax (from a psychological perspective). Explanations of this are discussed, based on bi-variate and multi-variate statistical analyses.

Adult↗
PubMed1987

Job stress, mental health, and accidents among offshore workers in the oil and gas extraction industries.

Psychosocial and occupational stressors among 194 male employees on drilling rig and production platform installations in the United Kingdom and Dutch sectors of the North Sea were studied. Mental well-being and job satisfaction were also assessed, with attention to the incidence of accidents offshore. This occupational group were found to be much less satisfied with their jobs than their onshore counterparts. Although overall mental well-being compared favorably with that of the general population, levels of anxiety were significantly higher. Multivariate analysis showed "relationships at work and at home" to be a strong predictor of both job dissatisfaction and mental ill-health. Type A coronary-prone behavior was also found to be a significant predictor of reduced mental well-being and increased accident rates offshore.

Accidents, Occupational↗
PubMed1986

Stress coping strategies in commercial airline pilots.

The literature reveals a clear deficiency in knowledge of how aircraft pilots cope with psychosocial stress. The subject is not only of intrinsic interest, but because of the nature of the pilots' personality and their work, the subject is also relevant to other occupations. In a study of the coping strategies of 442 commercial aircraft pilots, four factors were identified: stability of relationships and home life, reason and logic, social support, and wife's involvement. Implications for the study of other occupations are also highlighted.

Adaptation, Psychological↗