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Biomedical subjects

C L Chiang

Publications and source records attributed to C L Chiang.

24 records · Page 2Linked to original sources
PubMed1976

Making annual indexes of health.

A discrete-state, continuous-time Markov model of health states and state transition probabilities is outlined as the basis of a health index that would reflect the annual health distribution and expected health changes of a population. The final index is an additive one, summing expected durations of the various health states over the entire population sample. The weights attached to the expected durations are derived from the instantaneous incidence rates, or intensity functions, that define the transition probabilities. A general procedure for collecting data during overlapping 6-week periods from numerous population subsamples is described.

Health Status Indicators↗
PubMed1976

Ability of H-2 regions to induce graft-vs-host disease.

Individual young adult F1 hybrid mice were irradiated with 500 R and 24 hr later injected with 5 X 10(7) spleen cells obtained from a sex-matched parental-strain donor. The injected animals were then followed for a period of 3 months and loss of body weight, mortality rate, and other signs of fatal graft-vs-host disease (GVHD) were recorded. The donor-recipient strain combinations were selected in such a way as to provide genetic differences in the entire H-2 complex, the K or D regions alone, the K or the D end, and the central (I) regions alone. The data obtained on only few combinations indicate that strong GVHD (100% mortality rate within the first month after the injection) occurs only in those donor-recipient combinations which differ in the entire H-2 complex or in the K end (K + I regions). Much weaker GVHD (mortality rate of only 50% or less and death of individual mice spread over the entire observation period) is observed when the donor and the host differ in either the K, I, or D region alone. The degree of GVHD induced by three regions, when taken singularly, is about the same. Surprisingly, the K-region GVHD was somewhat stronger in combinations of mutant strains in comparison with recombinant-strain combinations.

Animals↗