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Biomedical subjects

C L Berry

Publications and source records attributed to C L Berry.

At least 91 records · Page 5Linked to original sources
PubMed1981

Sarcomere relaxation and ischaemic myocardial injury.

Material from hearts known to have had recent myocardial infarction and biopsies of dog hearts subjected to an experimental procedure producing ischaemic injury, were examined by polarising microscopy. A technique which depends on the relaxation of sarcomeres on ischaemic areas of myocardia was used and assessed for its value in the diagnosis of early myocardial infarction. We found no statistically significant difference in sarcomere lengths in ischaemic and control heart muscle in man. The dog study failed to show changes with a study period of up to 2 h after ligation. We do not support the suggestion that sarcomere length is a useful measurement in the demonstration of early myocardial ischaemic injury in man.

Animals↗
PubMed1981

Effect of beta-aminopropionitrile on the static elastic properties and blood pressure of spontaneously hypertensive rats.

The static elastic properties of the aorta ad systolic blood pressure in the caudal artery have been measured in 55 spontaneously hypertensive rats of the AS strain. Animals were divided into five groups and treated from the age of 4 to 12 weeks as follows: (1) 0.25 mm silver clip positioned around the right renal artery; (2) renal artery clipped as group (1) followed by daily injection of beta-aminopropionitrile fumarate (beta-APN); (3) daly injection of beta-APN without clipping; (4) daily injection of 0.09% saline; (5) untreated. Mean systolic blood pressures at 12 weeks of age were Group (1) 21.8; Group (2) 16.2; Group (3) 17.0; Group (4) 18.0; Group (5) 17.5 (units kPa). Thus, administration of beta-APN prevents the development of renal hypertension in clipped animals while producing no significant alteration in animals with intact renal arteries. At pressures within the physiological range the functional distensibility of all the treated animals was greater than that of the controls (pressure strain elastic modulus significantly lower). Similar changes were observed in the variation of structural distensibility (incremental elastic modulus) with pressure. At any level of total strain greater than 0.7 the incremental elastic modulus of both groups of animals treated with beta-APN was significantly less than control values. These observations are consistent with reports in the literature that administration of beta-APN causes a reduction in either the amount of cross-linked or normal scleroprotein in the aorta.

Aminopropionitrile↗
PubMed1980

Intravascular papillary endothelial hyperplasia in the skin and subcutaneous tissue.

Twenty-four cases of Intravascular Papillary Endothelial Hyperplasia (IPEH) have been studied. IPEH comprises approximately 2% of benign and malignant vascular tumours of the skin and subcutaneous tissue. This peculiar tumour-like process lacks specific clinical characteristics and its diagnosis must be based on microscopic examination. Histologically is is characterised by a papillary proliferation of endothelial cells forming vascular channels, commonly associated with thrombus and in some cases simulating angiosarcoma.--Follow-up of 10 cases indicates a benign clinical course.

Adult↗
PubMed1980

Blood group antigens in vascular tumours. Evaluation of the immunoperoxidase technique.

Determination of blood group isoantigens A, B and H, was performed in benign and malignant vascular tumours of the skin and subcutaneous tissue, using the immunoperoxidase technique. No differences were noted between benign haemagioendotheliomas from children or adults: neither tumour showed the presence of antigens in intercapillary cells. Reactive conditions such as angiolymphoid hyperplasia with eosinophilia showed an intense positive reaction to blood group substances of the endothelial proliferative cells. In malignant tumours no relationship between tumour differentiation and loss of blood group isoantigens was seen. Cases of Kaposi's sarcoma did not show antigens in spindle cells or capillaries but in medium sized vessels variable preservation or loss of blood group isoantigens was found.

Blood Group Antigens↗
PubMed1980

Morphometry of intrarenal arteries in progressive sclerosis.

Vessels of known position in the vascular tree of the kidneys of two cases with a long history of progressive systemic sclerosis--one normotensive, one hypertensive--were examined morphometrically. Medial thickness, intimal thickness and the relative content of collagen and elastin in the vascular media were measured. Smooth muscle nuclei were counted in the arterial cross section. These morphometric data were compared with those obtained from two autopsy cases--one with a history of essential hypertension, one without any hypertensive history. The findings suggest that progressive sclerosis induces intimal thickening in all branches of the renal artery down to a distented diameter of 200 microns. In the case where progressive sclerosis was complicated by arterial hypertension increased medial thicknesses were found, similar to the findings in the case with a history of essential hypertension.

Arteries↗
PubMed1980

The variability of blood group antigens in gastric carcinoma as demonstrated by the immunoperoxidase technique.

In this study the immunoperoxidase technique was used to demonstrate the blood group antigens A, B and H in normal gastric mucosa and primary and metastatic gastric carcinomas. No clear relationship between tumour differentiation and preservation of blood group antigens was found. In some well differentiated tumours there was a marked loss of blood group substance, whereas in other poorly differentiated tumours, both primary and metastatic, it was easily detectable. In some tumours an inverse relationship between A or B and H activity was noted. This observation is consistent with the theory that in some malignant cells there is a blocking of the normal step-by-step elongation of the carbohydrate portion of blood group substances.

ABO Blood-Group System↗
PubMed1978

The effects of damage to the renal tubular cell population in growing rats.

Intraperitoneal injection of mercuric chloride in the rat was used to study the effect of tubular injury on renal growth in intact and in unilaterally nephrectomised animals. If a reduction in the size of the tubular cell pool was effected, hypertrophy of surviving cells, rather than hyperplasia, would be the dominant response in treated animals. The remaining kidney in animals which had undergone nephrectomy showed hyperplasia without hypertrophy. However, unilaterally nephrectomised animals treated with mercuric chloride showed evidence of hypertrophy only, with no hyperplasia.

Acute Kidney Injury↗
PubMed1978

Static mechanical properties and chemical composition of the aorta of spontaneously hypertensive rats: a comparison with the effects of induced hypertension.

The static elastic properties and medial scleroprotein content of the aorta have been examined in spontaneously hypertensive rats (AS strain) aged 6 and 20 weeks (group SH). The results are compared with data from two previous studies on normal (group N) and induced hypertensive animals (group H). Spontaneous hypertension is associated with a relative increase in elastin and decrease in collagen when compared with the normal aorta. These changes are similar to, although smaller in magnitude than, those associated with induced hypertension. Elasticity measurements show that the functional stiffness (incremental strain) of the aorta in group SH is greater than normal. However, this difference diminishes with age, suggesting an adaptive response which tends to maintain the functional stiffness near to normal levels.

Age Factors↗
PubMed1978

Hypertension and arterial development. Long-term considerations.

A considerable body of evidence supports the view that haemodynamic factors, acting during growth and development, affect the ultimate form of the larger arteries. Many of the changes induced in vessels by high pressure or flow are adaptive and effectively minimise alterations in vessel function, but these changes may predispose to degenerative disease. 'Early intervention' in arterial disease implies intervention in the first and second decades of life.

Aging↗
PubMed1976

Streptokinase in acute myocardial infarction: a controlled multicentre study in the United Kingdom.

In a multicentre trial of streptokinase in acute myocardial infarction 302 patients received an intravenous infusion of 2 500 000 IU of streptokinase over 24 hours, while 293 patients served as controls. Neither group received anticoagulants unless indicated by thromboembolic complications. No significant difference in mortality was evident during inpatient treatment nor at six-week or six-month follow-up. The inpatient death rate was 12-6% in the streptokinase group and 13-7% among controls. There was no significant difference in the peak levels or pattern of enzyme increase. The incidence of cardiac failure and reinfarction was similar in the two groups, but major arrhythmias were less common in those on streptokinase (P less than 0-05). In the streptokinase group there were 36 minor and six more serious haemorrhagic complications. Gastrointestinal haemorrhage may have contributed to the death of one patient in each group. There were 18 thromboembolic complications in the streptokinase group and 38 among the controls. Pathological examination of the hearts of 25 patients who had taken streptokinase and 24 controls showed no striking differences between the groups, but haemorrhagic infarcts were found in three patients who had received streptokinase. An infusion of streptokinase within 24 hours of the onset of acute myocardial infarction does not significantly affect the mortality or course of the illness up to six months.

Aged↗
PubMed1976

Effects of hypertension on the static mechanical properties and chemical composition of the rat aorta.

The contributions of the relative radius, relative wall thickness, incremental strain, incremental elastic modulus, and medial scleroprotein content to the static elastic properties of the rat aortic wall have been examined in three groups of rats. Controls, rats made hypertensive at four weeks of age, and rats whose blood pressure was lowered after 6 weeks hypertension, were studied. The results show evidence of adaptive changes in the aorta of hypertensive animals, and that irreversible alterations in the mechanical properties of the wall may be induced by a brief period of hypertension. A direct relationship between aortic medial scleroprotein content and the elastic properties of the wall is demonstrated.

Age Factors↗