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Biomedical subjects

C L Anderson

Publications and source records attributed to C L Anderson.

185 records · Page 11Linked to original sources
PubMedDate not supplied

Concurrent clinical and metabolic derangements in the newborn rat: a late phase sepsis model.

Gram negative sepsis is a leading cause of human newborn morbidity and mortality. The clinical signs and glucose and lactate concentration during the late phase of newborn rat endotoxicosis has not been well characterized. In order to define a late phase model of sepsis, simultaneous clinical signs (loss of response to pain [RP] and/or righting reflex [RR]), and metabolic (glucose, lactate) concentrations were studied in the 10 day old Sprague-Dawley rat. The rats were fasted for four hours and then injected with either saline (control) or 0.1 mg per kg Salmonella enteritidis (LD90 @ 24) endotoxin intraperitoneally. Rats were then examined every 15 minutes beginning two hours post injection for the presence or absence of loss of RR and/or loss of RP. Central blood samples were collected for determination of glucose and lactate at the moment of loss of the predetermined clinical parameter. Metabolic parameters were also determined on saline treated controls time matched to the experimental groups. Rats were grouped as follows: GrI, (n = 10), saline three hours post injection; GrIII, (n = 10), saline five hours post injection; GrII, (n = 45), endotoxin at the moment of loss of RR; GrVI, (n = 14), endotoxin at 8.5 hrs post injection (termination of experiment, all with loss of RR); GrIV, (n = 11) endotoxin at loss of RP; and GrV, (n = 10) saline at 8.5 hr post injection.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Cord blood thyrotropin screening for primary hypothyroidism on Caribbean island: a rapid communication.

Screening programs using determinations of serum thyroxine have demonstrated that congenital hypothyroidism occurs in one in 4,000 live births in North America. More than 90 percent of affected infants have primary hypothyroidism with elevated plasma thyrotropin (TSH) levels. Since the feasibility of newborn screening and incidence of congenital hypothyroidism in other less well developed areas of the world is not well defined, a study was undertaken of neonatal primary hypothyroid screening infants born on the Caribbean island of St. Lucia in the Lesser Antilles. Three hundred thirteen cord blood samples were collected on filter paper and transported 3,000 miles to Loyola University of Chicago, Stritch School of Medicine (LUMC). From LUMC, the samples were transported to the Illinois State Metabolic Screening Laboratory for determination of TSH by radioimmunoassay (RIA). In this group of newborns, the mean TSH level in cord blood was 10.23 +/- 0.29 microIU per ml (SEM). It is concluded that screening programs for neonatal primary hypothyroidism can be performed using reference laboratories far removed from the population under observation.

Atlantic Islands↗
PubMedDate not supplied

Sensitivity of hospitals' E-coded data in identifying causes of children's violence-related injuries.

E codes classify causes of injury as unintentional, intentional, and undetermined. E-coded discharge data from hospitals provide an opportunity to use this source of morbidity data for planning, implementation, and evaluation of injury and violence prevention activities. This study explores the extent to which E-coded data from hospitals identify injuries that result from violent acts. Cases were identified through a multihospital population-based surveillance system of pediatric injuries. Those cases with injury as a result of violence, designated by study criteria, were compared with those with E codes that were classified as intentional. The analysis indicated that 25 percent of injuries to children resulting from violence may not be accounted for through the use of E codes. The majority of the undetected injury cases resulting from violence involved child abuse. Researchers and other persons who design and conduct injury and violence prevention programs should be aware of the undercount and associated issues when using E-coded hospital discharge data for surveillance of injuries resulting from violence.

Adolescent↗