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Biomedical subjects

C King

Publications and source records attributed to C King.

At least 163 records · Page 9Linked to original sources
PubMed1982

Anesthetic management for birth of the "Canton" quadruplets: a multidisciplinary team approach.

This article presents a case study of the successful anesthesia management in the birth of quadruplets at Aultman Hospital in Canton, Ohio. A review of recent literature is also provided. With the increasing use of fertility drugs, multiple births will inevitably cease to be viewed as a rare phenomenon. Anesthesia practitioners will increasingly be presented with the challenge of planning for the management of these patients. The authors believe an anesthetic plan must be integrated into a multidisciplinary team approach to achieve successful management of parturient and neonates.

Adult↗
PubMed1981

TRH increases locomotor activity in rats after injection into the hypothalamus.

Thyrotropin releasing hormone (TRH) had been reported to increase locomotor activity in rats and mice. In an attempt to localize this phenomenon, TRH (1 microgram, bilateral) was injected into the caudate nucleus, septum and hypothalamus of rats. Locomotor activity increased after injection of TRH into the hypothalamus, but not into the other two sites. These data may indicate that increased locomotor activity is elicitable by TRH only in sharply delimited sites in the nervous system.

Animals↗
PubMed1981

Effects of beta-endorphin and morphine on the sleep-wakefulness behavior of cats.

The effects of beta-endorphin and of morphine SO4 (0.5 microgram and 2.0 microgram, respectively, injected intraventricularly) upon the sleep-wakefulness behavior of cats were examined. Both agents produced insomnia. Deep slow wave sleep was sharply inhibited, and rapid eye movement (REM) sleep was entirely suppressed. Light slow wave sleep, occurring in brief, isolated episodes, became the most abundant stage of sleep. The nuchal electromyogram was markedly increased after both agents. Naloxone (100 microgram/kg), injected subcutaneously 30 min before beta-endorphin or morphine SO4, entirely reversed these agents' effects on the two stages of slow wave sleep, and antagonized the exaggerated electromyogram. But naloxone did not counteract the REM-suppressant effect of either beta-endorphin or morphine SO4. Total sleep time reverted towards control values after naloxone pretreatment, but not entirely; the difference may be due to the persistent deficit of REM sleep. The data may indicate an involvement of an inner opioid in the regulation of sleep and wakefulness in the cat, and may point to a role for more than one endorphin receptor in the effects of opioids on the states of vigilance in cats.

Animals↗
PubMed1976

Results in treating 210 patients with detrusor overactivity incontinence of urine.

Eighty (72.7 per cent) of 110 patients with detrusor overactivity (in controlled and uncontrolled series) showed improvement with parasympatholytic drug (propantheline bromide or dycyclomine HC1) therapy. Twenty per cent of patients on placebo therapy showed improvement. When standard surgery improved bladder neck funnelling, detrusor overactivity was improved in 77.3 per cent of cases. Surgery failed to improve detrusor overactivity in 54.5 per cent of patients who showed no significant bladder neck funnelling. Bladder neck funnelling appears to be a cause of detrusor overactivity in some women. Results with medical and surgical therapy were not associated with significant change in bladder capacity.

Clinical Trials as Topic↗
PubMed1976

Electromyographic and pressure studies in the canine bladder.

The dog is unable to void until funnelling of the bladder neck occurs, even when the bladder is stressed with a large volume and with parasympathomimetic drugs. Nil or very little pressure rise occurs just prior to micturition. Well-coordinated voiding is associated with simultaneous electrical activity in either the upper urethra and bladder neck or these two areas plus the fundus, with predominance of electrical activity (frequency and amplitude) in the bladder neck in both circumstances. In cooordinate electrical activity is seen in bladder fundus, bladder neck, and upper urethra with incoordinate voiding.

Animals↗
PubMed1976

The implantation of natural tooth form bioglasses in baboons. A preliminary report.

This report describes a 6-month screening study comparing the tissue responses of several bioglass natural tooth implants in adult female baboons. The dental implants were designed to elicit osteogenesis at the interface of the implant and the oral tissues. This is in contrast to those types of implant materials that are merely biologically acceptable. Incisor teeth were extracted, dupplicated in bioglass, returned to the natural sockets, and splinted to the adjacent natural tooth, where they remained splinted for 3 months and then free standing for an additional 3 months. Microscopic evaluation revealed distinct histopathologic characteristics with certain bioglass formulas, such as ankylosis, a pseudofibrous capsule with fibers running parallel to the root surface, or an apparently true periodontal membrane with properly oriented Sharpey's fibers. True cementogenesis was not found.

Animals↗