Adenocarcinoma of the uterine corpus following irradiation for cervical cancer.
Explore the source record for details and available documents.
Adenocarcinoma↗
Biomedical subjects
C K Tang
Publications and source records attributed to C K Tang.
Müllerian adenosarcoma of the uterine cervix.
We present a tumor of the uterine cervix that was composed of histologically benign glandular epithelium and a malignant stromal component, justifying the term müllerian adenosarcoma. Ultrastructurally the stromal cells resemble the endometrial stromal cells, the tumor cells of an endolymphatic stromal myosis of the uterine cervix, and the stromal cells of a stromomyoma of the uterus. In addition there is evidence strongly suggesting a differentiation toward smooth muscle. The patient exhibited no evidence of disease one year after surgery.
Female↗
Are all adenomatoid tumors adenomatoid mesotheliomas?
The ultrastructure of three histologically typical adenomatoid tumors of the epididymis is presented. Two of the three tumors showed morphologic features of mesothelium similar to those reported in the literature. The third tumor demonstrated a multilayered basal lamina and Weibel-Palade bodies, both of which have been found consistently in sclerosing hemangiomas. Although the ultrastructure of the first two tumors confirms the theory of a mesothelial origin of adenomatoid tumors, the findings of the third tumor indicate that a histologically typical adenomatoid tumor may not necessarily be a mesothelioma and that electron microscopy is indispensable in establishing their nature. These findings also lead us to suggest that the term adenomatoid tumor should remain in use for light microscopic diagnosis, and that the term adenomatoid mesothelioma should be applied only when the mesothelial nature of an adenomatoid tumor is proven by electron microscopy. For those that show ultrastructural evidence of endothelial origin, the term adenomatoid angioma seems to be appropriate and accurate. It is possible that the adenomatoid angioma represents a variant of the histiocytoid hemangioma.
Adenoma↗
An unusual pelvic tumor with benign glandular, sarcomatous, and Wilms' tumor-like components.
We present a pelvic tumor occurring in a 23 year old woman in which a Wilms' tumor-like element was predominant. The presence of a benign glandular component surrounded by small spindle and round malignant cells paralleled that encountered in adenosarcoma of the uterine body and cervix. The possible histogenesis is discussed. Clinically the recurrent tumor showed evidence of a response to chemotherapy. Treatment was complicated by petit mal seizures, for which adriamycin was responsible. The patient exhibited no evidence of disease 22 months after the first operation.
Adult↗
A percolator vaporizer heated by reaction of neutralization of lime by carbon dioxide.
To improve the humidification of anesthetic gases without use of electricity and its associated dangers the principle of the coffee percolator has been applied to a new vaporizer. Coffee percolators work by introducing steam-driven spurts of boiling water into a perforated coffee container. A water vaporizer, which functions on this principle, was used substituting the fresh gas inflow of an anesthesia machine as the driving gas. The vaporizer was placed in the center of the lime canister of a circle system with coaxial-valved respiratory limbs. The gas-water mixture percolated through a multiple wire mesh gauze filter that prevented the introduction of water droplets into respiratory channels. All gases emerging from the bottom of the canister and reaching the inspiratory valve passed through the vaporizer above water level. The circuit delivered gases containing 4 to 9 mg of H2O/L above saturated values at ambient temperature (20.5 mg of H2O/L) within 15 minutes, if the fresh gas inflow was set at 2.5 L/min.
Anesthesiology↗
Growth and development of mice breathing 42% oxygen.
Explore the source record for details and available documents.
Animals↗
Routine cytodiagnosis of pulmonary malignancies.
Anesthesiologists normally discard the material routinely suctioned from the tracheal tube of patients under general endotracheal anesthesia. We preserved, and later examined microscopically, specimens from 10,621 patients. We found 11 cytologically abnormal smears from subjects with unsuspected pulmonary involvement, an incidence slightly more than 1:1,000. The accuracy of our method was assessed by calculation of the percent of abnormal smears obtained from patients with prediagnosed bronchogenic carcinomas: 40% when suctioned material was immediately spread on slides, and 67% when cellular concentration was achieved by mucolysis followed by filtration or centrifugation. Secretions normally discarded can reveal much information that would otherwise be missed. Our method may be useful if applied to patients at risk (heavy smokers, workers with asbestos, nitrosamine, or benzopyrine, miners of radioactive material, etc) who undergo general anesthesia for incidental surgery.
Adolescent↗
Exposure to halothane and enflurane affects learning function of murine progeny.
This study was conducted to assess the learning function of murine progeny born of mothers that had received either 1% or 2% halothane or 2% or 4% enflurane, on days 6 and 10 or days 14 and 17 or gestation. Their timed performance at the age of 6 to 7 weeks was compared in a maze with that of control mice of similar ages that had not been exposed to anesthetics prenatally. All mice exposed to halothane in utero performed poorly at first, especially the group with mothers exposed to 2% halothane on days 14 and 17 of pregnancy. By the 10th training period, the performance of all mice improved but remained significantly slower than control mice. The offsprings of mice exposed to enflurane also performed poorly on the first training period, but between the fifth and seventh training periods, made statistically significant progress. However, they too remained slower in maze performance than control mice. Although blood pressure and arterial blood gas studies were only performed on two pregnant mice, data obtained suggest that the anesthetics did not have sufficient effect on respiration to affect our results. Second generation offspring, born to dams exposed to 2% halothane in utero late in pregnancy and sired by normal unexposed males, were also consistently slower than control mice, indicating a possible genetic effect induced by the anesthetic.
Animals↗
Management of adenoid cystic carcinoma of the uterine cervix (cylindroma): report of six cases and reappraisal of all cases reported in the medical literature.
We report 6 new cases of adenoid cystic carcinoma (cylindroma) of the uterine cervix (5, invasive cancer and 1, in situ cancer). All 6 patients were elderly women and 5 were hypertensive. Additionally, 3 (Patients 1, 2, and 4) were obese and 1 (Patient 3) had diabetes mellitus. Three patients were seen because of postmenopausal vaginal bleeding and 3 were found to have malignant cells on routine exfoliative cytologic examination. Histologically, the tumor cells were relatively uniform, with scanty cytoplasms and a palisading pattern at the periphery of the tumor masses. Round cystic spaces were found in all 6 cases and hyaline nodules were present in some of the cyclic spaces in 2. The tumors were found in Stages IA, IB, IIB, IIB, and IIIB (cases 1-4 and 6 respectively), and were treated with irradiation only. There have been only 38 cases of invasive adenoid cystic carcinoma of the cervix reported in the world medical literature. We review the treatment and survival for all 38 cases previously reported and add 5 new cases.
Aged↗
Barr bodies in testis with Klinefelter syndrome.
Barr bodies are described in the interstitial cells of testes of a chromatin-positive patient with Klinefelter syndrome. Ultrastructural studies confirm the origin of the Barr body from the nuclear chromatin. Ultrastructurally the interstitial cells showed diminished, smooth endoplasmic reticulum and lipid droplets probably indicating impaired function.
Adult↗
Giant pseudomalignant granuloma.
A patient who developed rapidly growing, multicentric, cutaneous tumors clinically resembling pyogenic granuloma is reported. In spite of the fact that the local lesions expanded rapidly and contained cytologically "malignant" cells which appeared to invade dermal vessels, the patient had a benign clinical course. The differential diagnosis of "giant pseudomalignant granuloma" is discussed.
Adult↗
Mesenteric lymphangioma. A case report with transmission and scanning electron microscopic studies.
A mesenteric lymphangioma was found in a 2-day-old newborn, thus attesting to the congenital nature of the lesion. The ultrastructural features of the tumor included a poorly developed, discontinuous basal lamina, and anchoring fibrils distinguished it from a hemangioma. An undulating surface of the endothelium and prominent grooving between the endothelial cells were found by scanning electron microscopy and were indistinguishable from arterial and lymphatic endothelial surfaces that have been studied by others.
Humans↗
Adenocarcinoma arising from extragonadal endometriosis 14 years after total hysterectomy and bilateral salpingo-oophorectomy for endometriosis: report of a case with ultrastructural studies.
Explore the source record for details and available documents.
Adenocarcinoma↗
Stromomyoma of the uterus.
We present a solitary uterine tumor that occurred in a 28-year-old woman who complained of vaginal bleeding. Grossly, the tumor was well circumscribed and composed of lobulated tissue that varied from yellow, tan and soft, to white and rubbery. At the light microscopic level, areas identical to those described and interpreted as sex-cord differentiation in a group of closely similar uterine tumors were found and obtained for electron microscopic study. Ultrastructurally, there were two basic types of cells, neither of which can be interpreted as sex-cord derivatives. Cells that closely resembled the predominant components of Clement and Scully's group I tumors were similar to the normal endometrial stromal cells. Cells that formed plexiform cords demonstrated features diagnostic of smooth muscle cells. Cellular contents in cells comprising the tubular structures resembling that interpreted as indistinguishable from that of a Sertoli-cell tumor (tubular androblastoma) were probably smooth muscle cells. We propose the term "Stromomyoma" to designate this peculiar uterine tumor. The similarity between our tumor and those reported in the literature raises the possibility that "uterine tumor resembling" ovarian sex-cord tumors" are actually stromomyomas.
Adult↗
Humidity and the anesthetized patient.
Damage to the ciliated cells of the tracheobronchial tree and incidence of postoperative pulmonary complications were measured by point-scoring systems in 202 patients who breathed dry and humidified anesthetic gases for 225 +/- 78 min. The incidence of postoperative pulmonary complications decreased as the humidity of administered anesthetic gases increased from 0 to 32.5 mg H2O/l. A similar relationship was found between the amount of inhaled moisture and the damage to the ciliated epithelium of the tracheobronchial tree. These results appear to indicate that a high inspired humidity is beneficial for operations on normothermic patients, and that cellular damage caused by dryness is a possible contributory factor in the production of the pulmonary atelectasis that follows stoppage of the mucociliary transport system in the immmediate postoperative period.
Adolescent↗
Metastatic lymphoma in the ureter complicated by bacteremia and fungemia.
A 64-year-old woman presented with retroperitoneal lymphoma metastatic to the left ureter. Lymphoma was not diagnosed and her clinical course was not fully explained until after surgery. The lack of superficial lymphoma delayed diagnosis and therefore prevented effective treatment. Her situation became unmanageable when it was complicated by bacteremia (E coli) and fungemia (Candida albicans).
Candidiasis↗
46, XY gonadal dysgenesis with secondary amenorrhea, virilization, and bilateral gonadoblastomas.
A phenotypic girl with secondary amenorrhea, enlargement of the clitoris, XY gonadal dysgenesis, and bilateral gonadoblastomas is described. The presence of secondary amenorrhea does not obviate the existence of a Y chromosome. The presence of the Y chromosome should be a warning that a gonadal tumor may be present and, therefore, gonadectomy must be done as soon as possible and preferably before puberty.
Adolescent↗
Dermoid cysts of the floor of the mouth and lateral neck.
Dermoid cysts of the floor of the mouth and submandibular area represent an unusual clinical entity. We present three such cases and review their clinical presentation and pathologic classification. This study stresses the importance of recognizing and excising any tract leading from such cysts to the midline mandible or hyoid, in order to avoid a recurrence, since these tracts may be epithelialized.
Adult↗