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Biomedical subjects

C K Chung

Publications and source records attributed to C K Chung.

At least 73 records · Page 4Linked to original sources
PubMed1982

Colorectal carcinoma: evaluation of histologic grade and factors influencing prognosis.

We analyzed 246 patients with adenocarcinoma of colorectum treated with "curative" surgery alone. In reviewing these cases it is apparent that patients with poorly differentiated tumor (Grade 3) have an increased likelihood of deep invasion of tumor through the bowel wall and lymph node metastases compared to well (Grade 1) or moderately differentiated tumor (Grade 2). Poor differentiation of the tumor, deep penetration through the bowel wall and lymph node metastases appear to represent unfavorable prognostic indices in patients operated upon. Age, sex, size of primary tumor, and large bowel site of tumor origin were unrelated to the prognosis. Compared to Grade 1 and 2 tumors, patients with Grade 3 lesions had more local recurrences and/or distant metastases. These findings suggest that histologic grading is an important adjunct to the clinical evaluation and treatment planning of patients with colorectal carcinoma.

Adenocarcinoma↗
PubMed1982

Evaluation of adjuvant postoperative radiotherapy for lung cancer.

One hundred eighteen patients with lung cancer were retrospectively analyzed to determine whether postoperative radiotherapy (RT) improves survival. Patterns of treatment failure and three year NED (no evidence of disease) survival rates were assessed according to extent of tumor spread, histology, and treatment method. Patients with hilar or mediastinal node metastases were at higher risk of local failure compared to those with negative nodes. Postoperative RT reduced local recurrence and improved 3 year survival among patients with positive nodes. However, postoperative RT did not improve survival among those with negative nodes. Our data indicated that patients with positive hilar or mediastinal nodes may require postoperative RT to improve survival.

Adenocarcinoma↗
PubMed1982

Analysis of residual disease following preoperative radiotherapy versus initial surgery in endometrial carcinoma.

A clinicopathologic study of residual disease following pre-operative radiotherapy (RT) in 67 patients and initial surgery in 40 patients with early invasive endometrial carcinoma is presented. In 10%, extrauterine spread was found at operation. In 10% of patients, the histologic type, and in 19% the grade of tumor, differed between the curettage and hysterectomy specimens. Pre-op RT altered the depth of myometrial invasion and frequency of vascular invasion, but there was no evidence that irradiation itself affected the histologic type or grade of tumor. The patients with residual tumor after pre-op RT had significantly more cancer-related deaths than those without residual disease. The high risk factors were deep myometrial invasion and residual disease outside the uterus. Vascular invasion did not affect the prognosis in this series. The importance of surgical-pathologic staging by initial surgery is discussed.

Adenocarcinoma↗
PubMed1982

Carcinoma of the lung: evaluation of histological grade and factors influencing prognosis.

The results in 96 patients with lung cancer who underwent lobectomy or pneumonectomy were analyzed. In reviewing the case histories of these patients, it became apparent that those with poorly differentiated tumor (grade 3) have an increased likelihood of positive lymph node metastases compared with those with well-differentiated (grade 1) or moderately differentiated (grade 2) tumor. Poor differentiation of the tumor, vascular invasion, and lymph node metastases appear to represent poor prognostic indices in patients undergoing operation. Compared with patients with grade 1 and grade 2 tumors, patients with a grade 3 adenocarcinoma had more local recurrences, while those with grade 3 squamous cell carcinoma had more distant metastases. The findings suggest that histological grading is an important adjunct to the clinical evaluation of and planning of treatment for patients with lung cancer.

Adenocarcinoma↗
PubMed1982

Taste acuity, plasma zinc levels, and weight loss during radiotherapy: a study of relationships.

Thirty-five patients who were to undergo radiotherapy and 13 normal subjects were evaluated with taste questionnaires, taste acuity tests, and plasma zinc analyses. The studies were repeated on the patients in the fifth week of radiotherapy. The mean taste thresholds for NaCl (salt), sucrose (sweet), HCl (sour), and urea (bitter) were elevated and the plasma zinc levels were lower (77.2 +/- 11.8 vs. 94.6 +/- 30.1 g/100 ml, p = 0.055) for the patients than for the controls. However, there was not a significant correlation between the taste thresholds and plasma zinc levels at any time. The mean weight loss experienced by the 14 patients who reported subjective taste alteration in the fifth week was 3.1 kg versus 0.1 kg (p = 0.005) for those who did not report taste alteration. The data suggest that alterations in taste acuity, but not plasma zinc levels, are associated with weight loss during radiotherapy.

Adult↗
PubMed1981

Histologic grade and prognosis of carcinoma of the cervix.

A histologic grading system based on tumor differentiation was applied in a study of 122 patients with stage IB and IIA squamous cell carcinoma of the uterine cervix. In general, the more dedifferentiated the primary tumor, the more bulky the primary lesion and the higher the incidence of pelvic node metastasis. Following treatment, patients with undifferentiated tumors had a higher incidence of tumor recurrence a lower 2-year survival rate than those with well or moderately differentiated lesions. These findings suggest that histologic grading is an important adjunct to the clinical evaluation of cervical cancer.

Adult↗
PubMed1980

Analysis of factors contributing to treatment failures in stages IB and IIA carcinoma of the cervix.

Between April, 1971, and September, 1977, 98 patients with Stages IB and IIA cervical cancer who underwent surgical exploration prior to treatment at Hershey Medical Center were studied. Those who had bulky primary tumor (greater than or equal to 4 cm) had a higher incidence of nodal metastases (80% vs. 16%), local recurrences (40% vs. 5%), and distant metastases (40% vs. 1%). Patients who had positive nodes had more local recurrences (24% vs. 6%) and distant metastases (28% vs. 0%). Those with grossly positive nodes had more distant metastases (60% vs. 7%) than those with microscopically positive nodes. Those who had positive nodes, vascular invasion, and/or deep invasion of the cervix (greater than or equal to 70% of thickness) in the radical hysterectomy specimen had more nodal metastases and local recurrences. Postoperative radiation seemed to prevent local recurrences (40% vs. 6%) and improve the 2-year tumor-free survival rate (94% vs. 55%). Patients who had bulky primary tumors and/or grossly positive nodes at laparatomy may require systemic therapy in view of the high incidence of distant failures.

Adenocarcinoma↗
PubMed1980

Histologic grading in the clinical evaluation of laryngeal carcinoma.

A histologic grading system based on tumor differentiation was applied in a study of 73 patients with epidermoid carcinoma of the larynx treated at the Milton S. Hershey Medical Center of the Pennsylvania State University from 1971 through September 1977. The supraglottic and subglottic primary tumors were more likely to be poorly differentiated than the glottic carcinomas. In general, the more poorly differentiated the primary tumor, the more advanced was the stage of disease, and the higher the incidence of cervical node metastasis. After treatment, grade 3 patients have a higher incidence of treatment failure and cancer death than grade 1 or 2 patients. The findings suggest that a histologic grading system is an important adjunct to the clinical evaluation.

Carcinoma, Squamous Cell↗