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Biomedical subjects

C J Mulder

Publications and source records attributed to C J Mulder.

At least 109 records · Page 6Linked to original sources
PubMed1987

Raised serum IgA to common cell envelope antigens supports enterobacterial inductive contribution to pathogenesis of secondary ankylosing spondylitis.

Ankylosing spondylitis (AS) is closely associated with the histocompatibility antigen HLA-B27. Pathogenesis of AS is thought to involve interactions between B27 and certain enterobacterial antigens. However, enterobacterial involvement is uncertain and contested by some. The present paper demonstrates raised serum IgA to a common enterobacterial heat modifiable major outer membrane protein (h-momp; Mr 35,000) in active AS (N = 25; IgA = 1485 +/- 20) compared with controls, who were hospital patients without known arthropathies or gastro-intestinal disease (N = 12; IgA = 548 +/- 59). Serum IgG and IgM did not differ statistically. Raised serum IgA to h-momp might indicate enterobacterial antigenic stimulation from the gastro-intestinal tract and thus support an inductive contribution of enterobacterial antigens to the pathogenesis of secondary AS. It does not necessarily imply direct involvement in the pathogenesis of primary AS. H-momp appears to be a convenient tool for serological studies of AS and at present is likely to be more suitable than other bacterial antigens.

Antigens, Bacterial↗
PubMed1986

Listeria monocytogenes neonatal meningitis in The Netherlands.

As part of a collaborative study of the epidemiology of bacterial meningitis, the bacteriological data and some clinical features concerning neonates with Listeria monocytogenes meningitis were analysed for the period 1976-1982. In this group of 12 patients the case mortality rate was 17%. Seventeen per cent of the children weighed less than 2500 g at birth. Sixty-seven % of the cases occurred in the absence of any known risk factor. Listeria monocytogenes type IV B was isolated in 75% of the cases.

Age Factors↗
PubMed1986

Disseminated gonococcal infection in elderly patients.

Four elderly patients (71, 53, 57, and 62 years old) had disseminated gonococcal infection. Three patients presented with suppurative arthritis and the fourth with fever, skin lesions, and malaise. Although the signs and symptoms did not differ from those in the younger age group, the diagnosis was not considered clinically. All gonococci were susceptible to penicillin.

Age Factors↗
PubMed1985

Susceptibility of 126 isolates of Escherichia coli from the cerebrospinal fluid of neonates to five antibiotics.

One hundred and twenty-six clinical isolates of Escherichia coli from the CSF of neonates, obtained in the Netherlands during 1976 to 1982, were tested for sensitivity to five antibiotics. The usefulness of the generally recommended initial therapy, a combination of ampicillin and gentamicin, is supported in the majority of cases. On the basis of the in-vitro results, cefotaxime would have been effective as a therapy for all cases. Ampicillin and cefuroxime resistance occurred mostly in neonates who had received antibiotics prophylactically, neonates whose mothers had fever during labour or in neonates who had been nursed in incubators for more than one week.

Anti-Bacterial Agents↗
PubMed1984

A study of 280 cases of neonatal meningitis in The Netherlands.

Within the framework of a more extensive study of the epidemiology of bacterial meningitis in The Netherlands (1976-1982), 280 cases of neonatal meningitis were investigated retrospectively. Escherichia coli (132 cases, 47%), Streptococcus agalactiae (68 cases, 24%), Listeria monocytogenes (12 cases, 4%) were the organisms most commonly isolated. The mortality rate for these 280 cases was 27%. The male-female ratio was 1.33:1. The minimum incidence for The Netherlands was calculated to be 23 per 100 000 live births.

Bacteria↗
PubMed1984

Neonatal meningitis caused by Escherichia coli in The Netherlands.

Bacteriological and clinical data on 132 children with neonatal meningitis caused by Escherichia coli were analyzed as a part of a larger study of bacterial meningitis undertaken between 1976 and 1982 in The Netherlands. Eighty-eight percent of the E. coli strains that were isolated carried the K1 capsular antigen. Most (80%) of these E. coli K1 strains were serotyped as O7, O18, O83, or were autoagglutinable. The male/female ratio of the infants was 1.64. In the majority of cases the onset of meningitis was at the end of the first week of life. The birth weight of 42% of the infants was less than or equal to 2,500 g, and congenital defects were present in 11% of the infants. Thirty-seven percent of the neonates had no recognized risk factors. The case fatality rate was 26%. Meningitis recurred in 8% of the survivors.

Age Factors↗